GlycoEnzDB
The Comprehensive Glyco-enzyme Database
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Ser|ThrR(-CHAR).jpg)
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Fuc(a1-0)Ser|ThrR(-CHAR).jpg)
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* During O-Fuc modification of TSR1 (thrombospondin type 1) repeat, the first step involves the transfer of fuc by Pofut2 to Ser/Thr in this domain. The absence of Pofut2 in mice results in early embryonic lethality with defects in gastrulation.
* The next step involves the transfers glucose to O-Fuc by a gene encoding the β3-glucosyltransferase, B3GLCT or B3GALTL. Mutations in B3GLCT in humans results in a multifaceted severe developmental disorder known as Peters-plus syndrome.
* Besides O-fuc, and C-mannosylation also occur on TSR1/thrombospondin-1 domains.
| ER | Cis- | Medial- | Trans- | TGN |
|---|---|---|---|---|
| miRNA Name | Pos. | Context Score | Frac. | Wt. Context | Frac. | Conserved | Quality |
|---|---|---|---|---|---|---|---|
| hsa-miR-6846-3p | 165-172 | -0.581 | 99.0 | -0.581 | 99.0 | noncon | |
| hsa-miR-7973 | 167-174 | -0.443 | 98.0 | -0.443 | 98.0 | noncon | |
| hsa-miR-6840-3p | 495-502 | -0.396 | 99.0 | -0.247 | 99.0 | noncon | |
| hsa-miR-1185-5p | 2495-2502 | -0.392 | 98.0 | -0.172 | 88.0 | noncon | |
| hsa-miR-3679-5p | 2495-2502 | -0.39 | 98.0 | -0.172 | 90.0 | noncon | |
| hsa-miR-7152-3p | 2141-2148 | -0.381 | 97.0 | -0.168 | 89.0 | noncon | |
| hsa-miR-7-5p | 2542-2549 | -0.372 | 98.0 | -0.164 | 94.0 | noncon | |
| hsa-miR-4504 | 288-295 | -0.361 | 98.0 | -0.361 | 99.0 | noncon | |
| hsa-miR-135b-5p | 1239-1246 | -0.359 | 97.0 | -0.185 | 91.0 | con | |
| hsa-miR-135a-5p | 1239-1246 | -0.359 | 97.0 | -0.185 | 91.0 | con | |
| hsa-miR-6825-3p | 1945-1951 | -0.356 | 96.0 | -0.158 | 84.0 | noncon | |
| hsa-miR-6776-3p | 595-602 | -0.349 | 98.0 | -0.219 | 95.0 | noncon | |
| hsa-miR-3925-3p | 40-47 | -0.349 | 96.0 | -0.349 | 97.0 | noncon | |
| hsa-miR-6780a-3p | 153-160 | -0.348 | 98.0 | -0.348 | 98.0 | noncon | |
| hsa-miR-1263 | 307-313 | -0.348 | 95.0 | -0.348 | 97.0 | noncon | |
| hsa-miR-6868-5p | 754-761 | -0.334 | 97.0 | -0.21 | 93.0 | noncon | |
| hsa-miR-4441 | 702-709 | -0.33 | 98.0 | -0.208 | 94.0 | noncon | |
| hsa-let-7e-3p | 1697-1703 | -0.328 | 89.0 | -0.17 | 78.0 | noncon | |
| hsa-miR-6754-5p | 702-709 | -0.325 | 98.0 | -0.205 | 94.0 | noncon | |
| hsa-miR-628-5p | 810-817 | -0.318 | 97.0 | -0.201 | 95.0 | noncon | |
| hsa-miR-1539 | 27-33 | -0.312 | 92.0 | -0.312 | 93.0 | noncon | |
| hsa-miR-5004-5p | 768-775 | -0.308 | 95.0 | -0.195 | 88.0 | noncon | |
| hsa-miR-6887-3p | 1903-1910 | -0.302 | 91.0 | -0.135 | 77.0 | noncon | |
| hsa-miR-1224-5p | 769-776 | -0.297 | 98.0 | -0.188 | 96.0 | noncon | |
| hsa-miR-4270 | 702-709 | -0.296 | 97.0 | -0.187 | 92.0 | noncon | |
| hsa-miR-4753-5p | 1495-1502 | -0.294 | 96.0 | -0.153 | 88.0 | noncon | |
| hsa-miR-1912 | 2464-2470 | -0.293 | 98.0 | -0.131 | 91.0 | noncon | |
| hsa-miR-892a | 994-1001 | -0.291 | 97.0 | -0.152 | 92.0 | noncon | |
| hsa-miR-4324 | 830-837 | -0.286 | 97.0 | -0.181 | 94.0 | noncon | |
| hsa-miR-505-3p.1 | 790-797 | -0.283 | 91.0 | -0.179 | 83.0 | noncon | |
| hsa-miR-6755-5p | 1994-2000 | -0.277 | 91.0 | -0.125 | 79.0 | noncon | |
| hsa-miR-3653-5p | 173-179 | -0.274 | 98.0 | -0.274 | 99.0 | noncon | |
| hsa-miR-124-3p.1 | 1742-1748 | -0.274 | 94.0 | -0.144 | 89.0 | con | |
| hsa-miR-6723-5p | 2576-2582 | -0.271 | 96.0 | -0.122 | 87.0 | noncon | |
| hsa-miR-4531 | 255-262 | -0.269 | 96.0 | -0.269 | 97.0 | noncon | |
| hsa-miR-6826-3p | 1904-1911 | -0.268 | 92.0 | -0.121 | 82.0 | noncon | |
| hsa-miR-124-5p | 991-998 | -0.263 | 92.0 | -0.138 | 80.0 | noncon | |
| hsa-miR-4999-5p | 269-276 | -0.262 | 93.0 | -0.262 | 95.0 | noncon | |
| hsa-miR-3972 | 1689-1695 | -0.261 | 94.0 | -0.137 | 88.0 | noncon | |
| hsa-miR-491-3p | 1117-1124 | -0.26 | 92.0 | -0.136 | 84.0 | noncon | |
| hsa-miR-4275 | 2512-2519 | -0.26 | 98.0 | -0.117 | 94.0 | noncon | |
| hsa-miR-1197 | 767-773 | -0.259 | 96.0 | -0.165 | 93.0 | noncon | |
| hsa-miR-4529-5p | 1493-1499 | -0.257 | 90.0 | -0.135 | 83.0 | noncon | |
| hsa-miR-6859-3p | 166-172 | -0.257 | 89.0 | -0.257 | 92.0 | noncon | |
| hsa-miR-3158-3p | 709-716 | -0.256 | 95.0 | -0.163 | 91.0 | noncon | |
| hsa-miR-6828-3p | 2386-2393 | -0.256 | 95.0 | -0.116 | 87.0 | noncon | |
| hsa-miR-378j | 2349-2356 | -0.252 | 95.0 | -0.114 | 86.0 | noncon | |
| hsa-miR-4717-5p | 50-56 | -0.251 | 95.0 | -0.251 | 96.0 | noncon |