GlycoEnzDB

General Information

Gene Symbol:

B4GALNT2

Protein name:

Beta-1,4 N-acetylgalactosaminyltransferase 2

Enzyme Class:

Glycosyltransferase

CAZy Family:

GT12

E.C. No:

2.4.1.*

Reaction (SNFG):

	+		→		+	UDP
	+		→		+	UDP

Reaction (IUBMB):

No specified reaction.

About

* Activity is similar to B4GalNT1, but substrate specificity is distinct as it forms the Sd_a or Cad antigen.
* B4GalNT2 is suppressed during gastric cancer.

Related Pathway

KEGG ORTHOLOGY:

K09655

KEGG Pathway:

No Record

Reactome:

R-HSA-446203

Related Database

Organism:

Homo sapiens

Uniprot:

Q8NHY0

NCBI GeneID:

124872

GlyMap GeneID:

124872

DNA_RefSeq:

NM_001159387.1

Protein_RefSeq:

NP_001152859.1

BRENDA:

Kinetic info.

OMIM number:

111730

GeneCards database:

B4GALNT2

Enzyme Specificity

Glycan Type:

N_linked, O_linked (mucin type), GSL

Compartment:

Cis, Medial, Trans, TGN

Substrate:

NeuAc(a2-3)Gal(b1-?)GlcNAc(b1-?) or NeuAc(a2-3)Gal(b1-?)GalNAc(a1-?)

Product:

NeuAc(a2-3)[GalNAc(b1-4)]Gal(b1-?)GlcNAc(b1-?) or NeuAc(a2-3)[GalNAc(b1-4)]Gal(b1-?)GalNAc(a1-?)

Constraints:

!Fuc(a1-2)@Gal(b1-?)

Simulation Parameters

Mechaelis-Menten parameters (suggested)
Vm: 0.0000037 (pmol/cell • hr) Km: 700000000 (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)

ER	Cis-	Medial-	Trans-	TGN

Expression Data {ref. 5} Source from NCBI gene database

Expression data are collected from NCBI gene database

Cancer Cell Line Encyclopedia {ref. 13} Source from Cancer Cell Line Encyclopedia database

Transcription factor {ref. 10}

No high degree of confidence data

miRNA-GlycoEnzyme Interactome {ref. 9}

miRNA Name	Pos.	Context Score	Frac.	Wt. Context	Frac.	Conserved
hsa-miR-509-3p	145-152	-0.573	99.0	-0.573	99.0	noncon
hsa-miR-3162-3p	109-116	-0.564	99.0	-0.564	99.0	noncon
hsa-miR-874-3p	190-197	-0.562	99.0	-0.562	99.0	noncon
hsa-miR-150-3p	90-97	-0.504	98.0	-0.504	99.0	noncon
hsa-let-7c-3p	226-233	-0.459	99.0	-0.459	99.0	noncon
hsa-miR-4433a-3p	71-78	-0.455	99.0	-0.455	99.0	noncon
hsa-miR-6132	235-241	-0.436	98.0	-0.436	98.0	noncon
hsa-miR-5190	181-188	-0.427	99.0	-0.427	99.0	noncon
hsa-miR-6836-5p	235-241	-0.421	98.0	-0.421	98.0	noncon
hsa-miR-1289	69-75	-0.417	97.0	-0.417	98.0	noncon
hsa-miR-1207-5p	236-242	-0.416	98.0	-0.416	99.0	noncon
hsa-miR-4755-5p	118-125	-0.411	99.0	-0.411	99.0	noncon
hsa-miR-5006-3p	118-125	-0.411	99.0	-0.411	99.0	noncon
hsa-miR-4763-3p	236-242	-0.406	98.0	-0.406	98.0	noncon
hsa-miR-204-5p	117-124	-0.404	98.0	-0.404	99.0	noncon
hsa-miR-211-5p	117-124	-0.396	98.0	-0.396	98.0	noncon
hsa-miR-6751-3p	127-133	-0.395	98.0	-0.395	99.0	noncon
hsa-miR-1199-5p	127-133	-0.391	98.0	-0.391	99.0	noncon
hsa-miR-136-5p	196-203	-0.354	98.0	-0.354	98.0	noncon
hsa-miR-6808-5p	237-243	-0.346	99.0	-0.346	99.0	noncon
hsa-miR-6893-5p	237-243	-0.346	99.0	-0.346	99.0	noncon
hsa-miR-1256	231-237	-0.342	97.0	-0.342	98.0	noncon
hsa-miR-6832-3p	116-123	-0.338	98.0	-0.338	98.0	noncon
hsa-miR-940	237-243	-0.328	99.0	-0.328	99.0	noncon
hsa-miR-4446-5p	112-119	-0.318	98.0	-0.318	98.0	noncon
hsa-miR-7973	161-167	-0.317	94.0	-0.317	96.0	noncon
hsa-miR-4317	193-199	-0.301	95.0	-0.301	96.0	noncon
hsa-miR-3977	248-254	-0.291	98.0	-0.291	98.0	noncon
hsa-miR-3157-3p	191-197	-0.285	97.0	-0.285	98.0	noncon
hsa-miR-6754-3p	155-161	-0.284	96.0	-0.284	97.0	noncon
hsa-miR-4761-3p	233-239	-0.278	98.0	-0.278	98.0	noncon
hsa-miR-134-5p	179-185	-0.273	94.0	-0.273	96.0	noncon
hsa-miR-105-5p	252-258	-0.273	98.0	-0.273	99.0	noncon
hsa-miR-7853-5p	252-258	-0.273	98.0	-0.273	99.0	noncon
hsa-miR-4446-5p	119-125	-0.269	97.0	-0.269	97.0	noncon
hsa-miR-374c-5p	205-212	-0.268	96.0	-0.268	97.0	noncon
hsa-miR-1226-3p	102-108	-0.268	95.0	-0.268	97.0	noncon
hsa-miR-3194-5p	28-34	-0.266	94.0	-0.266	95.0	noncon
hsa-miR-412-3p	155-161	-0.263	95.0	-0.263	97.0	noncon
hsa-miR-1263	143-149	-0.263	90.0	-0.263	93.0	noncon
hsa-miR-655-3p	205-212	-0.26	96.0	-0.26	97.0	noncon
hsa-miR-802	133-139	-0.254	96.0	-0.254	97.0	noncon
hsa-miR-4768-3p	72-78	-0.254	98.0	-0.254	98.0	noncon
hsa-miR-3118	179-185	-0.251	92.0	-0.251	94.0	noncon