GlycoEnzDB

General Information

Gene Symbol:

EDEM1

Protein name:

ER degradation-enhancing alpha-mannosidase-like protein 1

Enzyme Class:

CAZy Family:

GH47

E.C. No:

Reaction (SNFG):

No reaction

→

Reaction (IUBMB):

No specified reaction.

About

* Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle.
* It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan-independent manner

Related Pathway

KEGG ORTHOLOGY:

KEGG Pathway:

No Record

Reactome:

R-HSA-381038

Related Database

Organism:

Homo sapiens

Uniprot:

Q92611

NCBI GeneID:

9695

GlyMap GeneID:

9695

DNA_RefSeq:

NM_014674.2

Protein_RefSeq:

NP_055489.1

BRENDA:

Kinetic info.

OMIM number:

607673

GeneCards database:

EDEM1

Enzyme Specificity

Glycan Type:

N_linked

Compartment:

ER

Substrate:

No reaction(-CHAR)

Product:

(-CHAR)

Simulation Parameters

Mechaelis-Menten parameters (suggested)
Vm: (pmol/cell • hr) Km: (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)

ER	Cis-	Medial-	Trans-	TGN

Expression Data {ref. 5} Source from NCBI gene database

Expression data are collected from NCBI gene database

Cancer Cell Line Encyclopedia {ref. 13} Source from Cancer Cell Line Encyclopedia database

Transcription factor {ref. 10}

No high degree of confidence data