GlycoEnzDB

General Information

Gene Symbol:

LARGE2

Protein name:

LARGE xylosyl- and glucuronyltransferase 2

Enzyme Class:

Glycosyltransferase

CAZy Family:

GT49

E.C. No:

2.4.*.*

Reaction (SNFG):

+	→	+	UDP
+	→	+	UDP
+	→	+	UDP

Reaction (IUBMB):

No specified reaction.

About

* LARGE1 and LARGE2 are bifunctional enzymes with α(1-3)XylT and β(1-3)GlcAT activity
* They extends O-Man structures (core M3) on DAG1

Related Pathway

KEGG ORTHOLOGY:

K09668

KEGG Pathway:

No Record

Reactome:

R-HSA-5173105

Related Database

Organism:

Homo sapiens

Uniprot:

Q8N3Y3

NCBI GeneID:

120071

GlyMap GeneID:

120071

DNA_RefSeq:

NM_001300721.1

Protein_RefSeq:

NP_001287650.1

BRENDA:

Kinetic info.

OMIM number:

609709

GeneCards database:

LARGE2

Enzyme Specificity

Glycan Type:

O_linked (not mucin type)

Compartment:

Cis, Medial, Trans, TGN

Substrate:

GlcA(b1-4)Xyl(b1-4) or GlcA(b1-3) or Xyl(a1-?)

Product:

Xyl(a1-3)GlcA(b1-4)Xyl(b1-4) or Xyl(a1-3)GlcA(b1-3) or GlcA(b1-3)Xyl(a1-?)

Simulation Parameters

Mechaelis-Menten parameters (suggested)
Vm: (pmol/cell • hr) Km: (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)

ER	Cis-	Medial-	Trans-	TGN

Expression Data {ref. 5} Source from NCBI gene database

Expression data are collected from NCBI gene database

Expression Data in Cells

No expression data available.

Transcription factor {ref. 10}

No high degree of confidence data