GlycoEnzDB
The Comprehensive Glyco-enzyme Database
.jpg)
|
+ |
Man(a1-0)Ser|ThrR(-CHAR).jpg)
|
→ |
[GlcNAc(b1-6)]Man(a1-0)Ser|ThrR(-CHAR).jpg)
|
+ | UDP |
* ~30 % of all O-linked glycans in the brain are O-mannose based. This is initiated by protein O-mannosyltransferase 1 (POMT1) and POMT 2, followed by POMGnT1 activity.
* A brain-specific β1,6-N-GlcNAcT (MGAT5B) has been cloned that transfers β1,6GlcNAc to a-mannose in GlcNAc-β1,2-Man-a sequence on both N-glycans and O-mannosyl glycans. In vivo this enzyme is dominantly considered to act on o-mannose glycans of the brain.
* Due to its activity, a variety of extended structures can be formed on the O-mannose backbone including sialylated glycans, glycans with HNK-1 epitope, and those with Lewis X structures.
| ER | Cis- | Medial- | Trans- | TGN |
|---|---|---|---|---|
| miRNA Name | Pos. | Context Score | Frac. | Wt. Context | Frac. | Conserved | Quality |
|---|---|---|---|---|---|---|---|
| hsa-miR-4737 | 94-101 | -0.503 | 96.0 | -0.503 | 97.0 | noncon | |
| hsa-miR-3130-3p | 1541-1548 | -0.43 | 99.0 | 0.0 | 0.0 | noncon | |
| hsa-miR-6885-5p | 1052-1059 | -0.409 | 91.0 | -0.409 | 93.0 | noncon | |
| hsa-miR-328-5p | 1052-1059 | -0.363 | 91.0 | -0.363 | 93.0 | noncon | |
| hsa-miR-744-5p | 1192-1198 | -0.358 | 90.0 | -0.358 | 92.0 | noncon | |
| hsa-miR-3187-5p | 1184-1191 | -0.356 | 98.0 | -0.356 | 99.0 | noncon | |
| hsa-miR-4755-3p | 19-26 | -0.353 | 97.0 | -0.353 | 98.0 | noncon | |
| hsa-miR-5189-5p | 1184-1191 | -0.351 | 98.0 | -0.351 | 99.0 | noncon | |
| hsa-miR-6860 | 1184-1191 | -0.345 | 98.0 | -0.345 | 99.0 | noncon | |
| hsa-miR-296-5p | 348-355 | -0.345 | 93.0 | -0.345 | 95.0 | noncon | |
| hsa-miR-1254 | 1263-1270 | -0.34 | 98.0 | -0.34 | 98.0 | noncon | |
| hsa-miR-1285-3p | 1184-1191 | -0.335 | 98.0 | -0.335 | 99.0 | noncon | |
| hsa-miR-4749-3p | 576-583 | -0.333 | 95.0 | -0.333 | 96.0 | noncon | |
| hsa-miR-6766-5p | 1234-1241 | -0.332 | 94.0 | -0.332 | 95.0 | noncon | |
| hsa-miR-6788-3p | 339-346 | -0.331 | 91.0 | -0.331 | 94.0 | noncon | |
| hsa-miR-6756-5p | 1234-1241 | -0.321 | 92.0 | -0.321 | 94.0 | noncon | |
| hsa-miR-34c-5p | 1226-1233 | -0.303 | 91.0 | -0.303 | 93.0 | con | |
| hsa-miR-449b-5p | 1226-1233 | -0.295 | 90.0 | -0.295 | 93.0 | con | |
| hsa-miR-4540 | 1443-1450 | -0.292 | 94.0 | -0.292 | 96.0 | noncon | |
| hsa-miR-6837-5p | 461-468 | -0.288 | 95.0 | -0.288 | 96.0 | noncon | |
| hsa-miR-34a-5p | 1226-1233 | -0.285 | 90.0 | -0.285 | 92.0 | con | |
| hsa-miR-589-5p | 1435-1442 | -0.283 | 96.0 | -0.283 | 97.0 | noncon | |
| hsa-miR-3116 | 1263-1270 | -0.282 | 97.0 | -0.282 | 98.0 | noncon | |
| hsa-miR-1247-3p | 1307-1314 | -0.277 | 91.0 | -0.277 | 93.0 | noncon | |
| hsa-miR-4685-5p | 461-468 | -0.275 | 94.0 | -0.275 | 95.0 | noncon | |
| hsa-miR-3679-3p | 1456-1463 | -0.273 | 92.0 | -0.273 | 94.0 | noncon | |
| hsa-miR-6850-3p | 322-328 | -0.273 | 91.0 | -0.273 | 93.0 | noncon | |
| hsa-miR-612 | 1184-1191 | -0.267 | 98.0 | -0.267 | 98.0 | noncon | |
| hsa-miR-138-5p | 60-67 | -0.265 | 90.0 | -0.265 | 92.0 | con | |
| hsa-miR-6776-5p | 1236-1242 | -0.26 | 95.0 | -0.26 | 96.0 | noncon | |
| hsa-miR-6804-3p | 1540-1546 | -0.256 | 91.0 | 0.0 | 0.0 | noncon |