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+ |
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→ |
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+ | UDP |
* This is a Type II Golgi enzyme that aids the biosynthesis of Keratin sulfates (KS).
* KS is a major component of articular cartilage and cornea, while various KS proteins are also found in other tissues and cells.
* B3GNT7 preferentially acts to on sulfated type 2 glycans (Galβ1-4(SO3-6)GlcNAcβ1-3Galβ1-4(SO3-6)GlcNAc).
* It works in concert with CHST6 and B4GalT4 to extend KS polyLacNAc chains, and its function is reduced upon Gal-sulfation by CHST1.
* B3GNT7 is upregulated during ovarian cancer. It results in the expression of the HMOCC-1 mAb epitope.
ER | Cis- | Medial- | Trans- | TGN |
---|---|---|---|---|
B3GNT7/hsa-miR-939-3p |
---|
miRNA Target | Site Type | Pos. | Context Score | Frac. | Wt. Context | Frac. | Conserved | Quality |
---|---|---|---|---|---|---|---|---|
5'...AGGGGGUUCAGAU
GCCCAGGA
... 3' GACCCCUCGUCUC CGGGUCC C |
8mer | 1755-1762 | -0.31 | 97.0 | -0.31 | 97.0 | noncon | |
5'...CUAGGAAACUGAG
GCCCAGGA
... 3' GACCCCUCGUCUC CGGGUCC C |
8mer | 199-206 | -0.244 | 94.0 | -0.244 | 96.0 | noncon | |
5'...CUGGAGCCACAGU
GCCCAGG
C... 3' GACCCCUCGUCUC CGGGUCC C |
7mer-m8 | 75-81 | -0.193 | 90.0 | -0.193 | 94.0 | noncon | |
5'...GGAGGGAGCUACC
CCCAGGA
G... 3' GACCCCUCGUCUCC GGGUCC C |
7mer-A1 | 1661-1667 | -0.105 | 77.0 | -0.105 | 85.0 | noncon |