GlycoEnzDB
The Comprehensive Glyco-enzyme Database
GlycoEnzDB
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Instructions/Reference
DPM2


 General Info

 About

 Related Pathway

 Related Database

 Enzyme Specificity

 Simulation Para.

 Expression Data

 Cancer Cell Line

 Transcription factor

 miRNA-GlycoEnzyme


General Information
Gene Symbol:   
DPM2
Protein name:   
Dolichol phosphate-mannose biosynthesis regulatory protein
Enzyme Class:   
CAZy Family:   
E.C. No:   
Reaction (SNFG):   

No reaction →
Reaction (IUBMB):   
No specified reaction.
About

* This is an essential regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex, which includes DPM1 and DPM3.
* This protein is also part of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of GlcNAc UDP-GlcNAc to phosphatidylinositol during first step of GPI biosynthesis

Related Pathway
KEGG ORTHOLOGY:   
K09658
KEGG Pathway:   
ko00510  ko00563  ko01100 
Reactome:   
R-HSA-162699
Related Database
Organism:   
Homo sapiens
Uniprot:   
O94777 
NCBI GeneID:   
8818
GlyMap GeneID:   
8818
DNA_RefSeq:   
NM_003863.3 
Protein_RefSeq:   
NP_003854.1 
BRENDA:   
Kinetic info.
OMIM number:   
603564
GeneCards database:   
DPM2
Enzyme Specificity
Glycan Type:  
     N_linked
Compartment:  
     ER
Substrate:  
     No reaction(-CHAR)
Product:  
     (-CHAR)
Simulation Parameters
Mechaelis-Menten parameters (suggested)
Vm:       (pmol/cell • hr)       Km:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 20 10 0 RPKM
Expression data are collected from NCBI gene database
Cancer Cell Line Encyclopedia {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 140 120 100 80 60 40 20 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
No high degree of confidence data
miRNA-GlycoEnzyme Interactome {ref. 9}
DPM2/hsa-miR-185-3p
miRNA Target Site Type Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
5'...UCCUUACCCUGACA CAGCCCCA ...
3'   CUGGUCUCCUUUCG GUCGGGG A
 8mer 429-436 -0.634 99.0 -0.629 99.0 noncon
5'...UCCUCACGGAGGCC CAGCCCCA ...
3'   CUGGUCUCCUUUCG GUCGGGG A
 8mer 560-567 -0.41 96.0 -0.406 96.0 noncon
5'...AGGGAUGAGGCUGC CAGCCCC U...
3'   CUGGUCUCCUUUCG GUCGGGG A
 7mer-m8 24-30 -0.297 89.0 -0.297 92.0 noncon
5'...AGGCCCAGCCCCAA AGCCCCA G...
3'   CUGGUCUCCUUUCGG UCGGGG A
 7mer-A1 569-575 -0.251 84.0 -0.249 87.0 noncon