GlycoEnzDB
The Comprehensive Glyco-enzyme Database
GlycoEnzDB
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Instructions/Reference
GMPPA


 General Info

 About

 Related Pathway

 Related Database

 Enzyme Specificity

 Simulation Para.

 Expression Data

 Cancer Cell Line

 Transcription factor

 miRNA-GlycoEnzyme


General Information
Gene Symbol:   
GMPPA
Protein name:   
Mannose-1-phosphate guanyltransferase alpha
Enzyme Class:   
N_linked
CAZy Family:   
E.C. No:   
Tissues:   
all, Muscular, Epithelial, Connective, Nervous
Organs:   
Musculoskeletal, Pancreas, Bladder, Spleen, Mouth, Liver, Ovaries, Brain, Stomach, Lungs, Prostate, Eyes, Intestines, Kidney, Heart
Reaction (SNFG):   

Man(1P) → GDP-Man
Reaction (IUBMB):   
No specified reaction.
About

* Synthesizes GDP-mannose from mannose 1 phosphate and GTP.
* Knowledge of GMPPA and B is subsumed based on porcupine enzyme activity and the homology of porcupine and GMPPA and B structures.
* GDP-mannose is a critical reactant for sugar nucleotide synthesis and glycosylation, as it can be directly used in the synthesis of N-linked glycans and can be metabolized into other sugar nucleotide donors.

Related Pathway
KEGG ORTHOLOGY:   
KEGG Pathway:   
No Record 
Reactome:   
R-HSA-446205
Related Database
Organism:   
Homo sapiens
Uniprot:   
Q96IJ6 
NCBI GeneID:   
29926
GlyMap GeneID:   
29926
DNA_RefSeq:   
NM_013335.3 
Protein_RefSeq:   
NP_037467.2 
BRENDA:   
Kinetic info.
OMIM number:   
615495
GeneCards database:   
GMPPA
Enzyme Specificity
Glycan Type:  
     
Compartment:  
     
Substrate:  
     Man(1P)(-CHAR)
Product:  
     GDP-Man(-CHAR)
Constraints:  
     None
Simulation Parameters
Mechaelis-Menten parameters (suggested)
Vm:       (pmol/cell • hr)       Km:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 20 10 0 RPKM
Expression data are collected from NCBI gene database
Cancer Cell Line Encyclopedia {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 120 100 80 60 40 20 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
No high degree of confidence data
miRNA-GlycoEnzyme Interactome {ref. 9}
GMPPA/hsa-miR-4487
miRNA Target Site Type Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
5'...CCAGAAGGCCC CCAGCUC C...
3'   GACGGGAAGUC GGUCGAG A
 7mer-m8 21-27 -0.254 93.0 -0.254 95.0 noncon