GlycoEnzDB
The Comprehensive Glyco-enzyme Database
GlycoEnzDB
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PIGM


 General Info

 About

 Related Pathway

 Related Database

 Enzyme Specificity

 Simulation Para.

 Expression Data

 Cancer Cell Line

 Transcription factor

 miRNA-GlycoEnzyme


General Information
Gene Symbol:   
PIGM
Protein name:   
GPI mannosyltransferase 1
Enzyme Class:   
Glycosyltransferase
CAZy Family:   
GT50
E.C. No:   
2.4.1.*
Reaction (SNFG):   

GlcN(a1-6)(ancyl)PI → Man(a1-4)GlcN(a1-6)(ancyl)PI
Reaction (IUBMB):   
No specified reaction.
About

* PIGM together with PIGX mediated transfer of the first Man from Dol-P (donor) during GPI-protein synthesis.
* Here, PIGM has catalytic activity while PIGX has regulatory function.

Related Pathway
KEGG ORTHOLOGY:   
K05284
KEGG Pathway:   
ko00563  ko01100 
Reactome:   
R-HSA-162710
Related Database
Organism:   
Homo sapiens
Uniprot:   
Q9H3S5 
NCBI GeneID:   
93183
GlyMap GeneID:   
93183
DNA_RefSeq:   
NM_145167.2 
Protein_RefSeq:   
NP_660150.1 
BRENDA:   
Kinetic info.
OMIM number:   
610273
GeneCards database:   
PIGM
Enzyme Specificity
Glycan Type:  
     GPI
Compartment:  
     ER
Substrate:  
     GlcN(a1-6)(ancyl)PI(-CHAR)
Product:  
     Man(a1-4)GlcN(a1-6)(ancyl)PI(-CHAR)
Simulation Parameters
Mechaelis-Menten parameters (suggested)
Vm:       (pmol/cell • hr)       Km:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










No expression data available.
Cancer Cell Line Encyclopedia {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 30 20 10 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
No high degree of confidence data
miRNA-GlycoEnzyme Interactome {ref. 9}
PIGM/hsa-miR-4470
miRNA Target Site Type Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
5'...ACUUAAAAGCAAU GUUUGCC U...
3'   AGAGCCGAAGGUG CAAACGG U
 7mer-m8 140-146 -0.25 96.0 -0.25 97.0 noncon
5'...GGGACCACAGGUA UUUGCCA C...
3'   AGAGCCGAAGGUGC AAACGG U
 7mer-A1 3769-3775 -0.01 34.0 -0.005 48.0 noncon
5'...AAUUCAACAACAA UUUGCCA U...
3'   AGAGCCGAAGGUGC AAACGG U
 7mer-A1 3965-3971 -0.01 34.0 -0.005 48.0 noncon