GlycoEnzDB
The Comprehensive Glyco-enzyme Database
GlycoEnzDB
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SULF1


 General Info

 About

 Related Pathway

 Related Database

 Enzyme Specificity

 Simulation Para.

 Expression Data

 Cancer Cell Line

 Transcription factor

 miRNA-GlycoEnzyme


General Information
Gene Symbol:   
SULF1
Protein name:   
Extracellular sulfatase Sulf-1
Enzyme Class:   
CAZy Family:   
E.C. No:   
3.1.6.*
Reaction (SNFG):   
→
Reaction (IUBMB):   
No specified reaction.
About

* Extracellular sulfatases 1 and 2 are secreted proteins that remodel the glycosaminoglycans in the extracellular matrix by removing sulfate groups.
* SULF1 and SULF2 specifically act on GlcNAc 6-sulfate, diminishing the amount of heparan sulfate proteoglycans.
* SULF1 overexpression in ovarian cancer confers cisplatin resistance.

Related Pathway
KEGG ORTHOLOGY:   
KEGG Pathway:   
No Record 
Reactome:   
Related Database
Organism:   
Homo sapiens
Uniprot:   
Q8IWU6 
NCBI GeneID:   
23213
GlyMap GeneID:   
23213
DNA_RefSeq:   
NM_001128204.1 
Protein_RefSeq:   
NP_001121676.1 
BRENDA:   
Kinetic info.
OMIM number:   
610012
GeneCards database:   
SULF1
Enzyme Specificity
Glycan Type:  
     
Compartment:  
     
Substrate:  
     GlcNAc(a1-4 [6S])
Product:  
     GlcNAc(a1-4)
Constraints:  
     None
Simulation Parameters
Mechaelis-Menten parameters (suggested)
Vm:       (pmol/cell • hr)       Km:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 30 20 10 0 RPKM
Expression data are collected from NCBI gene database
Cancer Cell Line Encyclopedia {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 1200 1100 1000 900 800 700 600 500 400 300 200 100 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
No high degree of confidence data
miRNA-GlycoEnzyme Interactome {ref. 9}
SULF1/hsa-miR-199a-5p
miRNA Target Site Type Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
5'... CAUUUGAAUUCUGA ACACUGGA ...
3'   CUUGUCCAUCAGACU UGUGACC C
 8mer 421-428 -0.477 98.0 -0.477 98.0 con
5'... GAUUCAUUUUUAAC CACUGGA A...
3'   CUUGUCCAUCAGACUU GUGACC C
 7mer-A1 1214-1220 -0.156 85.0 -0.156 89.0 con