GlycoEnzDB
The Comprehensive Glyco-enzyme Database
GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
XXYLT1


 General Info

 About

 Related Pathway

 Related Database

 Enzyme Specificity

 Simulation Para.

 Expression Data

 Cancer Cell Line

 Transcription factor

 miRNA-GlycoEnzyme


General Information
Gene Symbol:   
XXYLT1
Protein name:   
Xyloside xylosyltransferase 1
Enzyme Class:   
Glycosyltransferase
CAZy Family:   
GT8
E.C. No:   
2.4.2.n3
Reaction (SNFG):   
+
→
+ UDP
Reaction (IUBMB):   
No specified reaction.
About

* Adds the 2nd (α1-3)Xyl to extend O-Glc chains in selected proteins that have an EGF domain with consensus sequence C-X-S-X-P/A-C.

Related Pathway
KEGG ORTHOLOGY:   
KEGG Pathway:   
No Record 
Reactome:   
Related Database
Organism:   
Homo sapiens
Uniprot:   
Q8NBI6 
NCBI GeneID:   
152002
GlyMap GeneID:   
152002
DNA_RefSeq:   
NM_152531.4 
Protein_RefSeq:   
NP_689744.3 
BRENDA:   
Kinetic info.
OMIM number:   
614552
GeneCards database:   
XXYLT1
Enzyme Specificity
Glycan Type:  
     O_linked (not mucin type)
Compartment:  
     
Substrate:  
     Xyl(a1-3)Glc(b1-?)Ser
Product:  
     Xyl(a1-3)Xyl(a1-3)Glc(b1-?)Ser
Simulation Parameters
Mechaelis-Menten parameters (suggested)
Vm:       (pmol/cell • hr)       Km:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 4 2 0 RPKM
Expression data are collected from NCBI gene database
Cancer Cell Line Encyclopedia {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 80 60 40 20 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
No high degree of confidence data
miRNA-GlycoEnzyme Interactome {ref. 9}
XXYLT1/hsa-miR-4498
miRNA Target Site Type Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
5'...CAAGGUUUUAAUGA CCAGCCCA ...
3'   GUCGUGAACGGGAC GGUCGGG U
 8mer 469-476 -0.402 97.0 -0.402 97.0 noncon
5'...CUUCCAAACGAAUG CCAGCCCA ...
3'   GUCGUGAACGGGAC GGUCGGG U
 8mer 500-507 -0.308 93.0 -0.308 95.0 noncon
5'...AGCAGAUAUCUUUC CCAGCCC U...
3'   GUCGUGAACGGGAC GGUCGGG U
 7mer-m8 1765-1771 -0.219 84.0 -0.001 19.0 noncon