EnzFunc

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Pathway Map
GNPNAT1



General Information
Gene Symbol:   
GNPNAT1
Protein name:   
Glucosamine 6-phosphate N-acetyltransferase
Enzyme Class:   
CAZy Family:   
E.C. No:   
2.3.1.4
Tissues:   
all, Muscular, Epithelial, Connective, Nervous
Organs:   
Reaction (SNFG):   

GlcN(6P) → GlcNAc(6P)
Reaction (IUBMB):   
No specified reaction.
About

• Converts glucosamine 6 phosphate to N-acetylglucosamine 6 phosphate in the hexosamine biosynthesis pathway.

Related Pathway
KEGG ORTHOLOGY:   
KEGG Pathway:   
No Record 
Reactome:   
R-HSA-446210
Related Database
Organism:   
Homo sapiens
Uniprot:   
Q96EK6 
NCBI GeneID:   
64841
GlyMap GeneID:   
64841
DNA aRefSeq:   
NM_198066.3 
Protein RefSeq:   
NP_932332.1 
BRENDA:   
Kinetic info.
OMIM number:   
616510
GeneCards database:   
GNPNAT1
Enzyme Specificity
Glycan Type:  
     N-linked
Compartment:  
     Cis
Substrate:  
     GlcN(6P)
Product:  
     GlcNAc(6P)
Constraints:  
     None
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 30 20 10 0 RPKM
Expression Data in Cells {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 80 60 40 20 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
No high degree of confidence data
miRNA-GlycoEnzyme Interactome {ref. 9}
miRNA Name Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
hsa-miR-6729-3p 208-215 -0.68 99.0 -0.68 99.0 noncon
hsa-miR-6769a-3p 24-31 -0.6 99.0 -0.6 99.0 noncon
hsa-miR-4433a-5p 717-724 -0.57 99.0 -0.457 99.0 noncon
hsa-miR-6866-5p 810-817 -0.533 99.0 -0.428 98.0 noncon
hsa-miR-4267 3105-3112 -0.516 99.0 -0.205 95.0 noncon
hsa-miR-4433a-5p 165-172 -0.512 99.0 -0.512 99.0 noncon
hsa-miR-769-3p 519-526 -0.476 99.0 -0.384 99.0 noncon
hsa-miR-455-3p.1 103-110 -0.473 99.0 -0.473 99.0 con
hsa-miR-4301 715-722 -0.465 99.0 -0.375 99.0 noncon
hsa-miR-4645-5p 3123-3130 -0.46 99.0 -0.024 61.0 noncon
hsa-miR-4802-5p 90-97 -0.46 99.0 -0.46 99.0 noncon
hsa-miR-3677-5p 2713-2720 -0.455 99.0 -0.23 95.0 noncon
hsa-miR-450b-3p 519-526 -0.455 99.0 -0.368 99.0 noncon
hsa-miR-331-5p 698-705 -0.454 98.0 -0.367 98.0 noncon
hsa-miR-4673 3123-3130 -0.45 99.0 -0.023 58.0 noncon
hsa-miR-1911-3p 1448-1455 -0.448 98.0 -0.227 94.0 noncon
hsa-miR-5591-3p 307-314 -0.44 98.0 -0.36 98.0 noncon
hsa-miR-5189-3p 1833-1840 -0.438 98.0 -0.222 93.0 noncon
hsa-miR-6854-3p 1340-1347 -0.436 95.0 -0.221 84.0 noncon
hsa-miR-299-3p 451-458 -0.431 99.0 -0.349 98.0 noncon
hsa-miR-4678 697-704 -0.428 98.0 -0.347 98.0 noncon
hsa-miR-4777-3p 1813-1820 -0.424 98.0 -0.216 90.0 noncon
hsa-miR-541-5p 3086-3093 -0.423 99.0 -0.171 95.0 noncon
hsa-miR-6514-3p 528-535 -0.418 99.0 -0.339 99.0 noncon
hsa-miR-182-5p 882-889 -0.409 98.0 -0.331 97.0 noncon
hsa-miR-491-3p 388-395 -0.405 97.0 -0.328 97.0 noncon
hsa-miR-4423-3p 2887-2894 -0.399 97.0 -0.204 92.0 noncon
hsa-miR-676-5p 980-987 -0.397 99.0 -0.322 99.0 noncon
hsa-miR-550b-2-5p 1768-1775 -0.386 98.0 -0.198 93.0 noncon
hsa-miR-4477b 3088-3095 -0.37 98.0 -0.151 90.0 noncon
hsa-miR-4764-3p 318-324 -0.362 97.0 -0.298 97.0 noncon
hsa-miR-7106-5p 1886-1893 -0.354 98.0 -0.182 93.0 noncon
hsa-miR-4640-5p 2410-2417 -0.338 94.0 -0.175 81.0 noncon
hsa-miR-671-5p 281-287 -0.337 97.0 -0.278 95.0 noncon
hsa-miR-138-1-3p 555-562 -0.335 99.0 -0.273 99.0 noncon
hsa-miR-1208 741-748 -0.335 98.0 -0.273 98.0 noncon
hsa-miR-4726-5p 2410-2417 -0.332 94.0 -0.172 80.0 noncon
hsa-miR-6512-5p 2897-2904 -0.33 99.0 -0.171 94.0 noncon
hsa-miR-571 3064-3070 -0.33 96.0 -0.149 83.0 noncon
hsa-miR-9-5p 222-228 -0.329 98.0 -0.329 98.0 con
hsa-miR-653-5p 408-415 -0.328 99.0 -0.267 98.0 con
hsa-miR-3166 327-333 -0.326 94.0 -0.269 94.0 noncon
hsa-miR-4455 2276-2283 -0.325 91.0 -0.168 79.0 noncon
hsa-miR-548x-5p 1012-1019 -0.321 99.0 -0.249 99.0 noncon
hsa-miR-548g-5p 1012-1019 -0.321 99.0 -0.249 99.0 noncon
hsa-miR-548aj-5p 1012-1019 -0.321 99.0 -0.249 99.0 noncon
hsa-miR-548f-5p 1012-1019 -0.321 99.0 -0.249 98.0 noncon
hsa-miR-6871-5p 1888-1895 -0.317 97.0 -0.164 88.0 noncon
hsa-miR-579-3p 191-198 -0.314 99.0 -0.314 99.0 noncon
hsa-miR-563 544-550 -0.314 95.0 -0.256 94.0 noncon
hsa-miR-4751 730-736 -0.314 95.0 -0.256 94.0 noncon
hsa-miR-4323 25-31 -0.309 97.0 -0.309 98.0 noncon
hsa-miR-6759-5p 2106-2113 -0.302 96.0 -0.157 89.0 noncon
hsa-miR-3144-3p 2734-2741 -0.301 95.0 -0.156 88.0 noncon
hsa-miR-4732-3p 463-469 -0.301 98.0 -0.246 98.0 noncon
hsa-miR-1260b 164-170 -0.299 95.0 -0.299 96.0 noncon
hsa-miR-1260a 164-170 -0.299 95.0 -0.299 96.0 noncon
hsa-miR-6755-5p 3031-3037 -0.295 92.0 -0.154 83.0 noncon
hsa-miR-370-5p 86-92 -0.295 97.0 -0.295 98.0 con
hsa-miR-376c-3p 636-643 -0.295 96.0 -0.241 95.0 noncon
hsa-miR-545-5p 611-618 -0.295 98.0 -0.241 97.0 noncon
hsa-miR-6834-3p 167-173 -0.293 94.0 -0.293 96.0 noncon
hsa-miR-3129-3p 477-484 -0.29 99.0 -0.237 99.0 noncon
hsa-miR-219b-5p 720-726 -0.29 93.0 -0.237 91.0 noncon
hsa-miR-5583-5p 477-484 -0.29 99.0 -0.237 98.0 noncon
hsa-miR-7856-5p 3089-3096 -0.288 99.0 -0.12 96.0 noncon
hsa-miR-302f 707-714 -0.288 97.0 -0.235 97.0 noncon
hsa-miR-371a-3p 931-937 -0.287 97.0 -0.235 95.0 noncon
hsa-miR-2115-5p 905-911 -0.284 94.0 -0.232 93.0 noncon
hsa-miR-5685 158-164 -0.282 97.0 -0.282 98.0 noncon
hsa-miR-664b-3p 191-198 -0.282 99.0 -0.282 99.0 noncon
hsa-miR-4529-3p 504-510 -0.282 92.0 -0.23 92.0 noncon
hsa-miR-7160-5p 758-764 -0.281 97.0 -0.23 96.0 noncon
hsa-miR-6755-5p 775-781 -0.28 91.0 -0.229 90.0 noncon
hsa-miR-6511a-3p 2000-2006 -0.278 94.0 -0.145 86.0 noncon
hsa-miR-6511b-3p 2000-2006 -0.278 94.0 -0.145 86.0 noncon
hsa-miR-4666b 385-391 -0.276 95.0 -0.226 95.0 noncon
hsa-miR-3145-5p 831-837 -0.276 97.0 -0.226 97.0 noncon
hsa-miR-4756-3p 2818-2825 -0.274 98.0 -0.143 95.0 noncon
hsa-miR-664a-3p 193-200 -0.273 98.0 -0.273 99.0 noncon
hsa-miR-6834-3p 719-725 -0.271 93.0 -0.222 92.0 noncon
hsa-miR-3670 2629-2636 -0.271 93.0 -0.141 82.0 noncon
hsa-miR-7109-3p 3117-3123 -0.27 96.0 -0.015 59.0 noncon
hsa-miR-5187-5p 1185-1192 -0.27 93.0 -0.141 83.0 noncon
hsa-miR-1249-5p 1226-1233 -0.269 93.0 -0.14 81.0 noncon
hsa-miR-380-5p 544-550 -0.269 92.0 -0.22 93.0 noncon
hsa-miR-6797-5p 1226-1233 -0.269 94.0 -0.14 81.0 noncon
hsa-miR-496.2 120-126 -0.269 97.0 -0.269 98.0 noncon
hsa-miR-6836-3p 1664-1671 -0.266 95.0 -0.139 88.0 noncon
hsa-miR-6134 2232-2239 -0.265 92.0 -0.139 81.0 noncon
hsa-miR-556-3p 310-317 -0.262 97.0 -0.217 97.0 noncon
hsa-miR-3156-3p 716-722 -0.261 95.0 -0.214 95.0 noncon
hsa-miR-30e-3p 106-113 -0.26 98.0 -0.26 98.0 noncon
hsa-miR-136-5p 829-835 -0.26 96.0 -0.213 95.0 noncon
hsa-miR-4312 37-43 -0.26 97.0 -0.26 98.0 noncon
hsa-miR-1257 1824-1831 -0.257 95.0 -0.134 86.0 noncon
hsa-miR-1226-3p 161-167 -0.256 94.0 -0.256 96.0 noncon
hsa-miR-3689a-3p 1887-1893 -0.256 92.0 -0.134 85.0 noncon
hsa-miR-4296 2413-2419 -0.255 93.0 -0.133 86.0 noncon
hsa-miR-135b-5p 1992-1999 -0.255 93.0 -0.133 87.0 noncon
hsa-miR-135a-5p 1992-1999 -0.255 93.0 -0.133 87.0 noncon
hsa-miR-3929 760-767 -0.255 99.0 -0.209 99.0 noncon
hsa-miR-3667-5p 2592-2599 -0.253 95.0 -0.132 89.0 noncon
hsa-miR-6778-3p 1663-1670 -0.253 94.0 -0.132 86.0 noncon
hsa-miR-30d-3p 106-113 -0.252 97.0 -0.252 98.0 noncon
hsa-miR-30a-3p 106-113 -0.252 97.0 -0.252 98.0 noncon
hsa-miR-4322 2413-2419 -0.251 93.0 -0.132 87.0 noncon
hsa-miR-659-5p 728-734 -0.25 92.0 -0.205 92.0 noncon