EnzFunc

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Pathway Map
GPI



General Information
Gene Symbol:   
GPI
Protein name:   
Glucose-6-phosphate isomerase
Enzyme Class:   
CAZy Family:   
E.C. No:   
5.3.1.9
Tissues:   
all, Muscular, Epithelial, Connective, Nervous
Organs:   
Reaction (SNFG):   

Glc(6P) → Fruc(6P)
Reaction (IUBMB):   
No specified reaction.
About

• Glucose-6-phosphate isomerase converts glucose-6-phosphate into fructose-6-phosphate.
• Second step in glycolysis pathway.

Related Pathway
KEGG ORTHOLOGY:   
KEGG Pathway:   
No Record 
Reactome:   
R-HSA-5628897
Related Database
Organism:   
Homo sapiens
Uniprot:   
P06744 
NCBI GeneID:   
2821
GlyMap GeneID:   
2821
DNA aRefSeq:   
NM_000175.4 
Protein RefSeq:   
NP_000166.2 
BRENDA:   
Kinetic info.
OMIM number:   
172400
GeneCards database:   
GPI
Enzyme Specificity
Glycan Type:  
     
Compartment:  
     
Substrate:  
     Glc(6P)
Product:  
     Fruc(6P)
Constraints:  
     None
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 30 20 10 0 RPKM
Expression Data in Cells {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 700 600 500 400 300 200 100 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
No high degree of confidence data
miRNA-GlycoEnzyme Interactome {ref. 9}
miRNA Name Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
hsa-miR-132-5p 282-289 -0.952 99.0 -0.814 99.0 noncon
hsa-miR-3157-5p 204-211 -0.533 99.0 -0.465 99.0 noncon
hsa-miR-6781-5p 984-991 -0.493 95.0 0.0 5.0 noncon
hsa-miR-5698 149-156 -0.481 97.0 -0.421 96.0 noncon
hsa-miR-4723-5p 149-156 -0.481 97.0 -0.421 96.0 noncon
hsa-miR-6870-5p 149-156 -0.473 97.0 -0.414 96.0 noncon
hsa-miR-7111-5p 149-156 -0.473 97.0 -0.414 96.0 noncon
hsa-miR-4487 1762-1769 -0.424 98.0 0.0 19.0 noncon
hsa-miR-4713-3p 2155-2162 -0.418 95.0 0.0 0.0 noncon
hsa-miR-3605-3p 284-290 -0.403 95.0 -0.354 94.0 noncon
hsa-miR-4642 279-285 -0.398 98.0 -0.35 98.0 noncon
hsa-miR-1293 87-94 -0.395 98.0 -0.347 98.0 noncon
hsa-miR-1304-5p 1683-1690 -0.395 98.0 0.0 26.0 noncon
hsa-miR-6499-5p 2063-2069 -0.365 91.0 0.0 5.0 noncon
hsa-miR-7155-5p 2285-2292 -0.363 98.0 0.0 0.0 noncon
hsa-miR-6776-5p 89-96 -0.362 98.0 -0.319 98.0 noncon
hsa-miR-3176 2166-2173 -0.356 98.0 0.0 0.0 noncon
hsa-miR-3184-5p 169-175 -0.348 95.0 -0.306 95.0 noncon
hsa-miR-146b-3p 2301-2308 -0.347 98.0 0.0 0.0 noncon
hsa-miR-3922-3p 2166-2173 -0.346 98.0 0.0 0.0 noncon
hsa-miR-6728-5p 258-264 -0.346 98.0 -0.305 98.0 noncon
hsa-miR-4695-5p 18-24 -0.342 98.0 -0.301 98.0 noncon
hsa-miR-6803-5p 162-168 -0.342 96.0 -0.301 96.0 noncon
hsa-miR-6801-5p 234-240 -0.339 97.0 -0.299 97.0 noncon
hsa-miR-6835-5p 162-168 -0.337 94.0 -0.297 93.0 noncon
hsa-miR-423-5p 169-175 -0.337 95.0 -0.297 94.0 noncon
hsa-miR-3126-5p 48-54 -0.33 97.0 -0.291 97.0 noncon
hsa-miR-6127 186-192 -0.328 96.0 -0.289 95.0 noncon
hsa-miR-4764-5p 256-262 -0.327 95.0 -0.288 95.0 noncon
hsa-miR-6875-5p 48-54 -0.319 97.0 -0.282 96.0 noncon
hsa-miR-4483 87-94 -0.319 98.0 -0.282 98.0 noncon
hsa-miR-6877-5p 985-991 -0.318 90.0 0.0 2.0 noncon
hsa-miR-4419a 186-192 -0.317 96.0 -0.28 95.0 noncon
hsa-miR-4510 186-192 -0.317 96.0 -0.28 95.0 noncon
hsa-miR-6133 186-192 -0.317 96.0 -0.28 95.0 noncon
hsa-miR-637 163-169 -0.314 96.0 -0.277 96.0 noncon
hsa-miR-5187-5p 258-264 -0.304 95.0 -0.268 95.0 noncon
hsa-miR-2467-5p 2316-2323 -0.302 97.0 0.0 0.0 noncon
hsa-miR-6751-5p 162-168 -0.301 95.0 -0.266 95.0 noncon
hsa-miR-6813-5p 168-174 -0.299 96.0 -0.264 95.0 noncon
hsa-miR-6515-5p 171-177 -0.297 95.0 -0.262 94.0 noncon
hsa-miR-6129 186-192 -0.295 95.0 -0.26 94.0 noncon
hsa-miR-6130 186-192 -0.295 95.0 -0.26 94.0 noncon
hsa-miR-6836-5p 1149-1155 -0.292 94.0 0.0 25.0 noncon
hsa-miR-5088-5p 125-131 -0.289 95.0 -0.255 96.0 noncon
hsa-miR-6797-5p 49-55 -0.287 95.0 -0.254 94.0 noncon
hsa-miR-6132 1149-1155 -0.285 94.0 0.0 21.0 noncon
hsa-miR-181c-3p 565-571 -0.283 98.0 0.0 23.0 noncon
hsa-miR-5193 288-294 -0.283 93.0 -0.005 46.0 noncon
hsa-miR-371b-3p 2304-2310 -0.283 93.0 0.0 0.0 noncon
hsa-miR-4779 50-56 -0.283 96.0 -0.25 96.0 noncon
hsa-miR-6085 168-174 -0.281 94.0 -0.248 94.0 noncon
hsa-miR-3178 1474-1481 -0.28 90.0 0.0 8.0 noncon
hsa-miR-3907 95-101 -0.278 92.0 -0.246 93.0 noncon
hsa-miR-4498 166-172 -0.278 91.0 -0.245 90.0 noncon
hsa-miR-485-5p 16-22 -0.277 95.0 -0.245 95.0 noncon
hsa-miR-1249-5p 49-55 -0.276 94.0 -0.244 93.0 noncon
hsa-miR-193b-5p 2283-2290 -0.275 90.0 0.0 0.0 noncon
hsa-miR-661 1693-1699 -0.273 96.0 0.0 21.0 noncon
hsa-miR-5195-3p 693-700 -0.271 93.0 0.0 22.0 noncon
hsa-miR-4505 153-159 -0.271 93.0 -0.239 93.0 noncon
hsa-miR-194-3p 2159-2166 -0.268 96.0 0.0 0.0 noncon
hsa-miR-5001-5p 166-172 -0.268 90.0 -0.237 90.0 noncon
hsa-miR-6777-3p 420-427 -0.267 95.0 0.0 22.0 noncon
hsa-miR-330-5p 91-97 -0.265 96.0 -0.234 95.0 con
hsa-miR-6873-5p 187-193 -0.263 95.0 -0.232 94.0 noncon
hsa-miR-3937 2014-2020 -0.261 91.0 0.0 7.0 noncon
hsa-miR-1273h-5p 1112-1119 -0.259 91.0 0.0 22.0 noncon
hsa-miR-6797-5p 171-177 -0.257 93.0 -0.227 92.0 noncon
hsa-miR-1249-5p 171-177 -0.257 93.0 -0.227 92.0 noncon
hsa-miR-6772-5p 1757-1764 -0.256 92.0 0.0 5.0 noncon
hsa-miR-5197-3p 40-46 -0.255 98.0 -0.226 97.0 noncon
hsa-miR-6884-5p 16-22 -0.255 94.0 -0.226 94.0 noncon
hsa-miR-4731-5p 164-170 -0.255 94.0 -0.225 94.0 noncon
hsa-miR-4286 451-457 -0.251 95.0 0.0 26.0 noncon