EnzFunc

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Pathway Map
MPI



General Information
Gene Symbol:   
MPI
Protein name:   
Mannose-6-phosphate isomerase
Enzyme Class:   
CAZy Family:   
E.C. No:   
5.3.1.8
Tissues:   
all, Muscular, Epithelial, Connective, Nervous
Organs:   
Reaction (SNFG):   

Man(6P) → Fruc(6P)
Reaction (IUBMB):   
No specified reaction.
About

• Mannose phosphate isomerase reversibly converts mannose-6-phosphate into fructose-6-phosphate.
• Involved in sugar nucleotide synthesis pathways.

Related Pathway
KEGG ORTHOLOGY:   
KEGG Pathway:   
No Record 
Reactome:   
R-HSA-4043916
Related Database
Organism:   
Homo sapiens
Uniprot:   
P34949 
NCBI GeneID:   
4351
GlyMap GeneID:   
4351
DNA aRefSeq:   
NM_001289156.1 
Protein RefSeq:   
NP_001276085.1 
BRENDA:   
Kinetic info.
OMIM number:   
154550
GeneCards database:   
MPI
Enzyme Specificity
Glycan Type:  
     
Compartment:  
     
Substrate:  
     Man(6P)
Product:  
     Fruc(6P)
Constraints:  
     None
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 20 10 0 RPKM
Expression Data in Cells {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 120 100 80 60 40 20 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
No high degree of confidence data
miRNA-GlycoEnzyme Interactome {ref. 9}
miRNA Name Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
hsa-miR-6070 1529-1536 -0.755 98.0 -0.021 26.0 noncon
hsa-miR-4443 1859-1866 -0.597 99.0 -0.018 53.0 noncon
hsa-miR-1268a 1161-1168 -0.595 96.0 -0.018 23.0 noncon
hsa-miR-1268b 1161-1168 -0.595 96.0 -0.018 23.0 noncon
hsa-miR-5580-5p 61-68 -0.581 99.0 -0.581 99.0 noncon
hsa-miR-650 1858-1865 -0.544 99.0 -0.016 41.0 noncon
hsa-miR-3612 1858-1865 -0.536 99.0 -0.016 39.0 noncon
hsa-miR-4663 528-535 -0.524 99.0 -0.524 99.0 noncon
hsa-miR-564 178-184 -0.516 98.0 -0.516 98.0 noncon
hsa-miR-6748-5p 69-76 -0.516 99.0 -0.516 99.0 noncon
hsa-miR-874-5p 121-128 -0.513 99.0 -0.513 99.0 noncon
hsa-miR-4754 1342-1349 -0.499 96.0 -0.015 19.0 noncon
hsa-miR-4455 67-74 -0.481 97.0 -0.481 98.0 noncon
hsa-miR-6842-3p 244-251 -0.474 99.0 -0.474 99.0 noncon
hsa-miR-3652 243-250 -0.471 99.0 -0.471 99.0 noncon
hsa-miR-563 1478-1485 -0.466 98.0 -0.014 42.0 noncon
hsa-miR-4430 243-250 -0.46 99.0 -0.46 99.0 noncon
hsa-miR-211-5p 1919-1926 -0.454 99.0 0.0 0.0 noncon
hsa-miR-204-5p 1919-1926 -0.446 99.0 0.0 0.0 noncon
hsa-miR-4999-3p 348-355 -0.441 98.0 -0.441 98.0 noncon
hsa-miR-3660 537-544 -0.438 99.0 -0.438 99.0 noncon
hsa-miR-5193 611-618 -0.434 98.0 -0.434 98.0 noncon
hsa-miR-3934-5p 450-457 -0.431 99.0 -0.431 99.0 noncon
hsa-miR-6827-3p 1025-1032 -0.425 93.0 -0.013 34.0 noncon
hsa-miR-380-5p 1478-1485 -0.424 98.0 -0.013 42.0 noncon
hsa-miR-4267 1896-1903 -0.421 99.0 -0.008 57.0 noncon
hsa-miR-214-3p 166-173 -0.413 99.0 -0.413 99.0 noncon
hsa-miR-5589-5p 517-524 -0.41 99.0 -0.41 99.0 noncon
hsa-miR-6759-5p 70-77 -0.41 98.0 -0.41 98.0 noncon
hsa-miR-302f 672-679 -0.408 99.0 -0.407 99.0 noncon
hsa-miR-340-3p 1025-1032 -0.407 92.0 -0.013 35.0 noncon
hsa-miR-1184 605-612 -0.406 99.0 -0.406 99.0 noncon
hsa-miR-151a-5p 441-447 -0.4 94.0 -0.4 95.0 noncon
hsa-miR-151b 441-447 -0.4 94.0 -0.4 95.0 noncon
hsa-miR-596 823-830 -0.399 99.0 -0.013 68.0 noncon
hsa-miR-6811-5p 1453-1460 -0.397 98.0 -0.013 51.0 noncon
hsa-miR-3619-5p 166-173 -0.395 99.0 -0.395 99.0 noncon
hsa-miR-4459 34-41 -0.394 99.0 -0.394 99.0 noncon
hsa-miR-6080 1438-1445 -0.387 97.0 -0.012 49.0 noncon
hsa-miR-4455 364-371 -0.386 95.0 -0.386 96.0 noncon
hsa-miR-4526 537-544 -0.384 99.0 -0.384 99.0 noncon
hsa-miR-4537 1074-1081 -0.377 92.0 -0.012 23.0 noncon
hsa-miR-374b-3p 1914-1921 -0.376 98.0 0.0 0.0 noncon
hsa-miR-135a-3p 1804-1811 -0.376 97.0 -0.012 25.0 noncon
hsa-miR-610 525-532 -0.372 98.0 -0.372 98.0 noncon
hsa-miR-2467-3p 92-99 -0.371 98.0 -0.371 98.0 noncon
hsa-miR-5691 541-548 -0.369 98.0 -0.369 98.0 noncon
hsa-miR-6511b-5p 1453-1460 -0.368 98.0 -0.012 52.0 noncon
hsa-miR-8079 682-688 -0.362 99.0 -0.361 99.0 noncon
hsa-miR-6805-3p 541-548 -0.361 98.0 -0.361 98.0 noncon
hsa-miR-6848-5p 276-282 -0.36 93.0 -0.36 94.0 noncon
hsa-miR-4276 140-147 -0.356 98.0 -0.356 98.0 noncon
hsa-miR-6895-5p 1326-1333 -0.354 97.0 -0.011 28.0 noncon
hsa-miR-6805-5p 277-283 -0.353 94.0 -0.353 95.0 noncon
hsa-miR-4756-5p 759-766 -0.35 98.0 -0.014 46.0 noncon
hsa-miR-6856-5p 433-440 -0.348 99.0 -0.348 99.0 noncon
hsa-miR-6758-5p 433-440 -0.346 99.0 -0.346 99.0 noncon
hsa-miR-1321 759-766 -0.342 98.0 -0.014 45.0 noncon
hsa-miR-3678-3p 93-100 -0.342 98.0 -0.342 98.0 noncon
hsa-miR-3617-3p 168-175 -0.342 97.0 -0.342 97.0 noncon
hsa-miR-4739 759-766 -0.339 98.0 -0.013 42.0 noncon
hsa-miR-6749-5p 396-402 -0.337 92.0 -0.337 94.0 noncon
hsa-miR-761 166-173 -0.335 99.0 -0.335 99.0 noncon
hsa-miR-6772-5p 653-659 -0.335 97.0 -0.335 98.0 noncon
hsa-miR-1245a 682-688 -0.333 98.0 -0.332 99.0 noncon
hsa-miR-24-3p 454-461 -0.333 97.0 -0.333 98.0 noncon
hsa-miR-4640-5p 1325-1331 -0.333 94.0 -0.011 29.0 noncon
hsa-miR-6846-5p 276-282 -0.327 91.0 -0.327 93.0 noncon
hsa-miR-4505 1165-1172 -0.325 96.0 -0.011 39.0 noncon
hsa-miR-4726-5p 1325-1331 -0.323 93.0 -0.01 27.0 noncon
hsa-miR-377-5p 249-256 -0.318 97.0 -0.318 98.0 noncon
hsa-miR-1271-3p 886-893 -0.316 94.0 -0.01 35.0 noncon
hsa-miR-550a-5p 886-893 -0.308 94.0 -0.01 35.0 noncon
hsa-miR-550a-3-5p 886-893 -0.308 94.0 -0.01 35.0 noncon
hsa-miR-6829-5p 938-944 -0.304 95.0 -0.01 41.0 noncon
hsa-miR-6851-5p 255-261 -0.301 94.0 -0.301 95.0 noncon
hsa-miR-4667-3p 1600-1607 -0.3 96.0 -0.01 40.0 noncon
hsa-miR-211-5p 618-625 -0.295 96.0 -0.295 97.0 noncon
hsa-miR-204-5p 618-625 -0.295 96.0 -0.295 97.0 noncon
hsa-miR-6832-5p 1488-1495 -0.294 95.0 -0.01 32.0 noncon
hsa-miR-196b-3p 1652-1658 -0.294 90.0 -0.01 28.0 noncon
hsa-miR-1228-5p 1249-1255 -0.292 92.0 -0.01 33.0 noncon
hsa-miR-6861-5p 77-83 -0.291 97.0 -0.291 98.0 noncon
hsa-miR-3622a-5p 179-185 -0.284 97.0 -0.284 98.0 noncon
hsa-miR-3194-5p 1354-1361 -0.283 95.0 -0.009 42.0 noncon
hsa-miR-6779-5p 1262-1269 -0.282 93.0 -0.009 44.0 noncon
hsa-miR-31-5p 465-472 -0.281 94.0 -0.281 96.0 noncon
hsa-miR-10a-5p 570-576 -0.279 97.0 -0.279 98.0 noncon
hsa-miR-4772-3p 1508-1515 -0.279 98.0 -0.009 60.0 noncon
hsa-miR-10b-5p 570-576 -0.279 97.0 -0.279 98.0 noncon
hsa-miR-4650-5p 631-637 -0.278 97.0 -0.278 98.0 noncon
hsa-miR-6741-3p 155-161 -0.276 93.0 -0.276 95.0 noncon
hsa-miR-6772-5p 68-74 -0.276 94.0 -0.276 96.0 noncon
hsa-miR-4507 75-81 -0.276 95.0 -0.276 96.0 noncon
hsa-miR-1273h-5p 1262-1269 -0.274 93.0 -0.009 43.0 noncon
hsa-miR-5006-3p 619-626 -0.272 97.0 -0.272 98.0 noncon
hsa-miR-4755-5p 1920-1926 -0.271 97.0 0.0 0.0 noncon
hsa-miR-5006-3p 1920-1926 -0.271 97.0 0.0 0.0 noncon
hsa-miR-3665 1640-1647 -0.271 93.0 -0.009 33.0 noncon
hsa-miR-3936 296-303 -0.269 95.0 -0.269 96.0 noncon
hsa-miR-5088-5p 755-761 -0.269 94.0 -0.011 48.0 noncon
hsa-miR-6759-3p 1908-1914 -0.268 94.0 0.0 0.0 noncon
hsa-miR-3689b-3p 1262-1269 -0.266 93.0 -0.009 45.0 noncon
hsa-miR-3689a-3p 1262-1269 -0.266 93.0 -0.009 45.0 noncon
hsa-miR-3689c 1262-1269 -0.266 93.0 -0.009 45.0 noncon
hsa-miR-30b-3p 1262-1269 -0.266 93.0 -0.009 44.0 noncon
hsa-miR-3158-5p 606-612 -0.266 97.0 -0.266 98.0 noncon
hsa-miR-6843-3p 549-555 -0.266 96.0 -0.266 97.0 noncon
hsa-miR-1200 1525-1532 -0.264 96.0 -0.009 50.0 noncon
hsa-miR-6773-5p 264-270 -0.264 91.0 -0.264 94.0 noncon
hsa-miR-6842-3p 1166-1173 -0.263 94.0 -0.009 38.0 noncon
hsa-miR-4446-3p 939-946 -0.261 94.0 -0.009 38.0 noncon
hsa-miR-6873-5p 431-437 -0.259 94.0 -0.259 96.0 noncon
hsa-miR-4794 60-66 -0.258 97.0 -0.258 98.0 noncon
hsa-miR-4505 244-250 -0.257 92.0 -0.257 94.0 noncon
hsa-miR-4755-5p 619-626 -0.256 96.0 -0.256 97.0 noncon
hsa-miR-509-3p 85-91 -0.255 90.0 -0.255 93.0 noncon
hsa-miR-5787 1165-1172 -0.255 96.0 -0.009 48.0 noncon
hsa-miR-3202 280-286 -0.255 94.0 -0.255 95.0 noncon
hsa-miR-4667-3p 333-340 -0.253 94.0 -0.253 96.0 noncon
hsa-miR-4710 252-258 -0.253 94.0 -0.253 95.0 noncon
hsa-miR-1266-3p 568-574 -0.253 94.0 -0.253 96.0 noncon
hsa-miR-4715-5p 469-475 -0.252 92.0 -0.252 95.0 noncon
hsa-miR-24-3p 153-159 -0.251 95.0 -0.251 96.0 noncon
hsa-miR-7845-5p 1803-1809 -0.251 92.0 -0.008 27.0 noncon
hsa-miR-4296 1791-1797 -0.25 92.0 -0.008 41.0 noncon