EnzFunc

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Pathway Map
RENBP



General Information
Gene Symbol:   
RENBP
Protein name:   
N-acylglucosamine 2-epimerase
Enzyme Class:   
CAZy Family:   
E.C. No:   
5.1.3.8
Tissues:   
all, Muscular, Epithelial, Connective, Nervous
Organs:   
Reaction (SNFG):   

GlcNAc → ManNAc
Reaction (IUBMB):   
No specified reaction.
About

• N-acetylglucosamine 2 epimerase converts GlcNAc to ManNAc.
• This enzyme participates in the N-glycolylneuraminic acid degradation pathway, which is found in non-human tissues.
• Binds to renin to inhibit its function.

Related Pathway
KEGG ORTHOLOGY:   
KEGG Pathway:   
No Record 
Reactome:   
R-HSA-446210
Related Database
Organism:   
Homo sapiens
Uniprot:   
P51606 
NCBI GeneID:   
5973
GlyMap GeneID:   
5973
DNA aRefSeq:   
NM_002910.5 
Protein RefSeq:   
NP_002901.2 
BRENDA:   
Kinetic info.
OMIM number:   
312420
GeneCards database:   
RENBP
Enzyme Specificity
Glycan Type:  
     
Compartment:  
     
Substrate:  
     GlcNAc
Product:  
     ManNAc
Constraints:  
     None
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 40 30 20 10 0 RPKM
Expression Data in Cells {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 220 200 180 160 140 120 100 80 60 40 20 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
No high degree of confidence data
miRNA-GlycoEnzyme Interactome {ref. 9}
miRNA Name Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
hsa-miR-937-3p 427-434 -0.78 99.0 -0.778 99.0 noncon
hsa-miR-486-3p 86-93 -0.654 99.0 -0.654 99.0 noncon
hsa-miR-4488 404-411 -0.569 99.0 -0.568 99.0 noncon
hsa-miR-1237-5p 404-411 -0.556 99.0 -0.555 99.0 noncon
hsa-miR-4697-5p 404-411 -0.537 99.0 -0.536 99.0 noncon
hsa-miR-6766-5p 90-97 -0.532 99.0 -0.532 99.0 noncon
hsa-miR-3617-3p 74-81 -0.522 99.0 -0.522 99.0 noncon
hsa-miR-4691-3p 207-214 -0.513 99.0 -0.513 99.0 noncon
hsa-miR-4286 171-178 -0.512 99.0 -0.512 99.0 noncon
hsa-miR-3202 21-28 -0.506 99.0 -0.506 99.0 noncon
hsa-miR-6756-5p 90-97 -0.505 98.0 -0.505 99.0 noncon
hsa-miR-644a 125-132 -0.503 99.0 -0.503 99.0 noncon
hsa-miR-4638-5p 270-277 -0.483 97.0 -0.483 97.0 noncon
hsa-miR-663a 413-419 -0.423 95.0 -0.422 96.0 noncon
hsa-miR-512-5p 210-217 -0.422 99.0 -0.422 99.0 noncon
hsa-miR-4650-3p 198-205 -0.404 97.0 -0.404 98.0 noncon
hsa-miR-6069 341-348 -0.402 97.0 -0.401 98.0 noncon
hsa-miR-4780 298-305 -0.401 98.0 -0.401 99.0 noncon
hsa-miR-4730 223-229 -0.398 96.0 -0.398 97.0 noncon
hsa-miR-663a 401-407 -0.387 93.0 -0.386 94.0 noncon
hsa-miR-6787-5p 413-419 -0.378 92.0 -0.377 94.0 noncon
hsa-miR-1908-5p 413-419 -0.375 93.0 -0.374 94.0 noncon
hsa-miR-3151-5p 88-94 -0.366 98.0 -0.366 98.0 noncon
hsa-miR-744-5p 382-388 -0.364 90.0 -0.363 92.0 noncon
hsa-miR-3197 191-197 -0.363 97.0 -0.363 97.0 noncon
hsa-miR-196a-3p 16-22 -0.354 97.0 -0.354 97.0 noncon
hsa-miR-1273d 156-163 -0.345 99.0 -0.345 99.0 noncon
hsa-miR-6787-5p 401-407 -0.342 90.0 -0.341 91.0 noncon
hsa-miR-1908-5p 401-407 -0.339 91.0 -0.338 92.0 noncon
hsa-miR-3605-3p 48-54 -0.332 92.0 -0.332 94.0 noncon
hsa-miR-4787-5p 411-417 -0.326 94.0 -0.325 96.0 noncon
hsa-miR-6861-3p 304-310 -0.326 94.0 -0.326 96.0 noncon
hsa-miR-3937 415-421 -0.317 95.0 -0.316 96.0 noncon
hsa-miR-4488 392-398 -0.312 94.0 -0.311 95.0 noncon
hsa-miR-8082 293-300 -0.303 96.0 -0.303 97.0 noncon
hsa-miR-488-3p 309-316 -0.296 98.0 -0.296 98.0 noncon
hsa-miR-638 236-242 -0.294 96.0 -0.294 97.0 noncon
hsa-miR-6125 220-226 -0.289 91.0 -0.289 93.0 noncon
hsa-miR-1237-5p 392-398 -0.286 92.0 -0.285 93.0 noncon
hsa-miR-4488 386-392 -0.277 90.0 -0.276 92.0 noncon
hsa-miR-6828-5p 321-328 -0.273 94.0 -0.272 96.0 noncon
hsa-miR-6816-3p 306-312 -0.269 98.0 -0.269 98.0 noncon
hsa-miR-6773-3p 166-172 -0.259 95.0 -0.259 96.0 noncon
hsa-miR-4534 293-300 -0.251 96.0 -0.251 97.0 noncon