Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).
Glycogene class |
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Pathway figs |
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Glycosylation |
Sugar Nucleotide |
Glucuronidation |
Glycan Degradation |
Pathway Map |
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• FUT7 (and FUT4) is ubiquitously expressed in all populations of peripheral blood cells including granulocytes, monocytes, and lymphocytes. It is also expressed in High Endothelial Venules (HEV).
• In blood cells, this is the dominant enzyme forming the sialyl Lewis-X structure and also 6 sulfo-sialyl Lewis-X. It exhibits strict enzyme specificity for sialyl lactosamine structures.
• It is tightly transcriptionally regulated, and plays a critical role in controlling L-, E- and P-selectin dependent leukocyte-endothelial cell adhesion interactions across species.
• Other FUTs like FUT3, 4, 5, 6, particularly FUT3 and 6, may also form the sLeX glycan in other tissue types.
ER | Cis- | Medial- | Trans- | TGN |
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miRNA Name | Pos. | Context Score | Frac. | Wt. Context | Frac. | Conserved | Quality |
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hsa-miR-1306-5p | 164-171 | -0.5 | 99.0 | -0.5 | 99.0 | noncon | |
hsa-miR-876-3p | 55-62 | -0.477 | 98.0 | -0.477 | 98.0 | noncon | |
hsa-miR-6865-3p | 281-288 | -0.465 | 99.0 | -0.465 | 99.0 | noncon | |
hsa-miR-6720-5p | 273-280 | -0.412 | 98.0 | -0.412 | 99.0 | noncon | |
hsa-miR-6887-3p | 211-218 | -0.404 | 96.0 | -0.404 | 97.0 | noncon | |
hsa-miR-6512-3p | 273-280 | -0.404 | 98.0 | -0.404 | 99.0 | noncon | |
hsa-miR-296-5p | 453-460 | -0.402 | 95.0 | -0.402 | 96.0 | noncon | |
hsa-miR-4763-3p | 407-414 | -0.387 | 98.0 | -0.387 | 98.0 | noncon | |
hsa-miR-4290 | 504-510 | -0.385 | 95.0 | -0.385 | 96.0 | noncon | |
hsa-miR-6826-3p | 212-219 | -0.361 | 96.0 | -0.361 | 97.0 | noncon | |
hsa-miR-1207-5p | 407-414 | -0.337 | 97.0 | -0.337 | 97.0 | noncon | |
hsa-miR-6810-3p | 124-130 | -0.329 | 95.0 | -0.329 | 97.0 | noncon | |
hsa-miR-7160-3p | 295-301 | -0.329 | 96.0 | -0.329 | 97.0 | noncon | |
hsa-miR-1825 | 147-154 | -0.32 | 97.0 | -0.32 | 98.0 | noncon | |
hsa-miR-6801-3p | 124-130 | -0.319 | 95.0 | -0.319 | 96.0 | noncon | |
hsa-miR-6889-3p | 107-114 | -0.317 | 96.0 | -0.317 | 97.0 | noncon | |
hsa-miR-7108-3p | 449-455 | -0.313 | 90.0 | -0.313 | 92.0 | noncon | |
hsa-miR-125b-5p | 495-502 | -0.31 | 96.0 | -0.31 | 97.0 | noncon | |
hsa-miR-378a-5p | 116-123 | -0.309 | 98.0 | -0.309 | 99.0 | noncon | |
hsa-miR-4726-3p | 344-351 | -0.309 | 98.0 | -0.309 | 98.0 | noncon | |
hsa-miR-6821-3p | 112-119 | -0.306 | 97.0 | -0.306 | 98.0 | noncon | |
hsa-miR-7162-5p | 119-126 | -0.295 | 96.0 | -0.295 | 97.0 | noncon | |
hsa-miR-6861-3p | 428-434 | -0.295 | 92.0 | -0.295 | 95.0 | noncon | |
hsa-miR-4664-5p | 314-321 | -0.295 | 94.0 | -0.295 | 96.0 | noncon | |
hsa-miR-4319 | 495-502 | -0.294 | 95.0 | -0.294 | 96.0 | noncon | |
hsa-miR-125a-5p | 495-502 | -0.294 | 95.0 | -0.294 | 96.0 | noncon | |
hsa-miR-5701 | 515-522 | -0.293 | 97.0 | -0.293 | 98.0 | noncon | |
hsa-miR-874-5p | 336-342 | -0.293 | 92.0 | -0.293 | 94.0 | noncon | |
hsa-miR-6811-3p | 394-401 | -0.29 | 96.0 | -0.29 | 97.0 | noncon | |
hsa-miR-5193 | 162-168 | -0.284 | 93.0 | -0.284 | 95.0 | noncon | |
hsa-miR-4456 | 57-63 | -0.284 | 95.0 | -0.284 | 96.0 | noncon | |
hsa-miR-4523 | 363-369 | -0.282 | 92.0 | -0.282 | 94.0 | noncon | |
hsa-miR-342-5p | 314-321 | -0.281 | 93.0 | -0.281 | 95.0 | noncon | |
hsa-miR-516b-3p | 119-126 | -0.279 | 95.0 | -0.279 | 97.0 | noncon | |
hsa-miR-516a-3p | 119-126 | -0.279 | 95.0 | -0.279 | 97.0 | noncon | |
hsa-miR-6511b-3p | 167-173 | -0.273 | 94.0 | -0.273 | 96.0 | noncon | |
hsa-miR-6511a-3p | 167-173 | -0.273 | 94.0 | -0.273 | 96.0 | noncon | |
hsa-miR-3918 | 375-381 | -0.27 | 94.0 | -0.27 | 95.0 | noncon | |
hsa-miR-3649 | 429-435 | -0.264 | 92.0 | -0.264 | 94.0 | noncon | |
hsa-miR-3173-5p | 292-298 | -0.264 | 94.0 | -0.264 | 96.0 | noncon | |
hsa-miR-2115-5p | 120-126 | -0.264 | 93.0 | -0.264 | 95.0 | noncon | |
hsa-miR-1254 | 60-66 | -0.258 | 96.0 | -0.258 | 97.0 | noncon | |
hsa-miR-1229-3p | 167-173 | -0.257 | 94.0 | -0.257 | 96.0 | noncon | |
hsa-miR-939-3p | 456-463 | -0.25 | 94.0 | -0.25 | 96.0 | noncon |