EnzFunc

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Pathway Map
GALK1



General Information
Gene Symbol:   
GALK1
Protein name:   
Galactokinase
Enzyme Class:   
CAZy Family:   
E.C. No:   
2.7.1.6
Organs:   
Reaction (SNFG):   

Gal → Gal(1P)
Reaction (IUBMB):   
No specified reaction.
About

• Phosphorylates galactose to form galactose 1 phosphate. Involved in the sugar nucleotide synthesis of UDP-galactose.
• Important enzyme for salvage pathway to obtain UDP-Gal via Leloir pathway

Related Pathway
KEGG ORTHOLOGY:   
KEGG Pathway:   
No Record 
Reactome:   
R-HSA-5609976
Related Database
Organism:   
Homo sapiens
Uniprot:   
P51570 
NCBI GeneID:   
2584
GlyMap GeneID:   
2584
DNA aRefSeq:   
 
Protein RefSeq:   
 
BRENDA:   
Kinetic info.
OMIM number:   
604313
GeneCards database:   
GALK1
Enzyme Specificity
Glycan Type:  
     
Compartment:  
     
Substrate:  
     Gal
Product:  
     Gal(1P)
Constraints:  
     None
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 30 20 10 0 RPKM
Expression Data in Cells {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 80 60 40 20 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
No high degree of confidence data
miRNA-GlycoEnzyme Interactome {ref. 9}
miRNA Name Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
hsa-miR-1288-3p 228-235 -0.562 99.0 -0.363 97.0 noncon
hsa-miR-493-5p 253-260 -0.517 99.0 -0.336 99.0 noncon
hsa-miR-5588-3p 134-141 -0.486 99.0 -0.419 99.0 noncon
hsa-miR-3942-3p 280-287 -0.468 99.0 -0.306 99.0 noncon
hsa-miR-4459 121-128 -0.426 99.0 -0.369 99.0 noncon
hsa-miR-451a 180-186 -0.423 95.0 -0.278 91.0 noncon
hsa-miR-1827 112-119 -0.407 98.0 -0.353 98.0 noncon
hsa-miR-4433a-3p 214-221 -0.399 99.0 -0.263 98.0 noncon
hsa-miR-4524b-3p 160-167 -0.387 99.0 -0.255 99.0 noncon
hsa-miR-8086 127-133 -0.382 96.0 -0.331 96.0 noncon
hsa-miR-1537-3p 181-187 -0.381 95.0 -0.252 91.0 noncon
hsa-miR-525-3p 86-92 -0.352 96.0 -0.306 96.0 noncon
hsa-miR-524-3p 86-92 -0.352 96.0 -0.306 96.0 noncon
hsa-miR-8071 231-237 -0.335 96.0 -0.222 94.0 noncon
hsa-miR-6089 243-249 -0.333 99.0 -0.221 98.0 noncon
hsa-miR-4523 67-73 -0.331 95.0 -0.288 94.0 noncon
hsa-miR-3622b-5p 155-161 -0.329 97.0 -0.286 96.0 noncon
hsa-miR-4695-5p 120-126 -0.315 97.0 -0.274 97.0 noncon
hsa-miR-7977 132-138 -0.303 98.0 -0.264 98.0 noncon
hsa-miR-4680-3p 286-292 -0.3 98.0 0.0 0.0 noncon
hsa-miR-1912 92-98 -0.299 98.0 -0.26 98.0 noncon
hsa-miR-4649-3p 114-120 -0.267 97.0 -0.233 97.0 noncon
hsa-let-7c-3p 254-260 -0.255 97.0 -0.171 94.0 noncon
hsa-miR-3614-5p 100-106 -0.252 96.0 -0.22 96.0 noncon
hsa-miR-1295b-5p 92-98 -0.252 97.0 -0.22 97.0 noncon
hsa-miR-6884-5p 118-124 -0.251 94.0 -0.219 94.0 noncon