EnzFunc

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Pathway Map
GALK2



General Information
Gene Symbol:   
GALK2
Protein name:   
N-acetylgalactosamine kinase
Enzyme Class:   
CAZy Family:   
E.C. No:   
2.7.1.157
Organs:   
Reaction (SNFG):   

GalNAc → GalNAc(1P)
Reaction (IUBMB):   
No specified reaction.
About

• Phosphorylates Nacetylgalactosamine to form Nacetylgalactosamine 1 phosphate. Involved in the sugar nucleotide synthesis of UDP-galactose.
• Important enzyme for salvage pathway to obtain UDP-GalNAc via Leloir pathway

Related Pathway
KEGG ORTHOLOGY:   
KEGG Pathway:   
No Record 
Reactome:   
No Record
Related Database
Organism:   
Homo sapiens
Uniprot:   
Q01415 
NCBI GeneID:   
2585
GlyMap GeneID:   
2585
DNA aRefSeq:   
NM_001001556.2 
Protein RefSeq:   
NP_001001556.1 
BRENDA:   
Kinetic info.
OMIM number:   
137028
GeneCards database:   
GALK2
Enzyme Specificity
Glycan Type:  
     
Compartment:  
     
Substrate:  
     GalNAc
Product:  
     GalNAc(1P)
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 6 4 2 0 RPKM
Expression Data in Cells {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 80 60 40 20 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
No high degree of confidence data
miRNA-GlycoEnzyme Interactome {ref. 9}
miRNA Name Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
hsa-miR-564 1582-1589 -0.723 99.0 -0.005 20.0 noncon
hsa-miR-891a-3p 61-68 -0.621 99.0 -0.621 99.0 noncon
hsa-miR-18b-3p 30-37 -0.608 99.0 -0.608 99.0 noncon
hsa-miR-4722-3p 47-54 -0.584 99.0 -0.584 99.0 noncon
hsa-miR-6727-3p 47-54 -0.574 99.0 -0.574 99.0 noncon
hsa-miR-4318 64-71 -0.54 99.0 -0.54 99.0 noncon
hsa-miR-3918 719-726 -0.531 99.0 -0.017 50.0 noncon
hsa-miR-4797-3p 248-255 -0.526 99.0 -0.516 99.0 noncon
hsa-miR-4662b 180-187 -0.523 99.0 -0.512 99.0 noncon
hsa-miR-5689 368-375 -0.519 98.0 -0.04 42.0 noncon
hsa-miR-644a 482-489 -0.505 99.0 -0.019 54.0 noncon
hsa-miR-8057 207-214 -0.499 99.0 -0.489 99.0 noncon
hsa-miR-16-1-3p 302-309 -0.494 99.0 -0.484 99.0 noncon
hsa-miR-371b-3p 33-39 -0.492 99.0 -0.492 99.0 noncon
hsa-miR-342-5p 976-983 -0.48 98.0 -0.003 29.0 noncon
hsa-miR-4664-5p 976-983 -0.462 98.0 -0.003 32.0 noncon
hsa-miR-4474-5p 605-612 -0.461 98.0 -0.017 53.0 noncon
hsa-miR-4693-5p 65-72 -0.458 99.0 -0.458 99.0 noncon
hsa-miR-4680-5p 388-395 -0.454 99.0 -0.035 66.0 noncon
hsa-miR-4711-5p 1442-1449 -0.451 99.0 -0.003 27.0 noncon
hsa-miR-133b 1183-1190 -0.45 97.0 -0.003 35.0 noncon
hsa-miR-133a-3p.2 1183-1190 -0.45 97.0 -0.003 35.0 noncon
hsa-miR-299-5p 678-685 -0.445 99.0 -0.017 59.0 noncon
hsa-miR-4426 180-187 -0.437 99.0 -0.428 99.0 noncon
hsa-miR-4647 180-187 -0.429 99.0 -0.421 99.0 noncon
hsa-miR-6833-3p 18-25 -0.429 98.0 -0.429 98.0 noncon
hsa-miR-4768-5p 18-25 -0.415 98.0 -0.415 98.0 noncon
hsa-miR-3911 919-926 -0.411 98.0 -0.003 24.0 noncon
hsa-miR-7975 1406-1413 -0.398 98.0 -0.003 35.0 noncon
hsa-miR-633 200-207 -0.394 98.0 -0.387 99.0 noncon
hsa-miR-451a 104-110 -0.375 93.0 -0.375 96.0 noncon
hsa-miR-5197-3p 776-783 -0.371 99.0 -0.012 57.0 noncon
hsa-miR-5004-3p 1525-1532 -0.37 97.0 -0.003 33.0 noncon
hsa-miR-574-5p 293-299 -0.361 96.0 -0.354 96.0 noncon
hsa-miR-6854-5p 723-730 -0.349 98.0 -0.012 51.0 noncon
hsa-miR-7162-5p 1152-1159 -0.344 97.0 -0.002 26.0 noncon
hsa-miR-5700 371-378 -0.344 99.0 -0.028 72.0 noncon
hsa-miR-6856-5p 887-894 -0.338 98.0 -0.002 40.0 noncon
hsa-miR-3151-3p 1638-1644 -0.337 96.0 -0.002 37.0 noncon
hsa-miR-516a-3p 1152-1159 -0.336 97.0 -0.002 27.0 noncon
hsa-miR-516b-3p 1152-1159 -0.336 97.0 -0.002 27.0 noncon
hsa-miR-610 1291-1298 -0.331 97.0 -0.002 18.0 noncon
hsa-miR-140-5p 700-706 -0.33 96.0 -0.013 48.0 noncon
hsa-miR-4677-3p 1310-1317 -0.323 98.0 -0.002 38.0 noncon
hsa-miR-548t-3p 193-200 -0.323 99.0 -0.317 99.0 noncon
hsa-miR-548ap-3p 193-200 -0.323 99.0 -0.317 99.0 noncon
hsa-miR-548aa 193-200 -0.323 99.0 -0.317 99.0 noncon
hsa-miR-1261 1247-1254 -0.321 97.0 -0.002 22.0 noncon
hsa-miR-6758-5p 887-894 -0.32 98.0 -0.002 40.0 noncon
hsa-miR-6875-3p 648-655 -0.318 98.0 -0.013 61.0 noncon
hsa-miR-183-5p.1 1584-1590 -0.317 96.0 -0.002 39.0 noncon
hsa-miR-3157-3p 31-37 -0.316 98.0 -0.316 98.0 noncon
hsa-miR-3915 421-428 -0.304 97.0 -0.012 37.0 noncon
hsa-miR-6895-5p 718-724 -0.302 96.0 -0.01 27.0 noncon
hsa-miR-924 772-778 -0.301 97.0 -0.01 43.0 noncon
hsa-miR-5007-5p 773-779 -0.3 97.0 -0.01 42.0 noncon
hsa-miR-4671-5p 507-513 -0.299 90.0 -0.012 22.0 noncon
hsa-miR-384 1407-1414 -0.297 98.0 -0.002 41.0 noncon
hsa-miR-6838-3p 50-56 -0.293 97.0 -0.293 98.0 noncon
hsa-miR-3127-5p 720-726 -0.293 94.0 -0.01 39.0 noncon
hsa-miR-1252-5p 80-86 -0.292 97.0 -0.292 97.0 noncon
hsa-miR-6833-5p 1592-1599 -0.281 98.0 -0.002 32.0 noncon
hsa-miR-3688-5p 62-68 -0.28 95.0 -0.28 96.0 noncon
hsa-miR-760 207-213 -0.272 92.0 -0.267 94.0 noncon
hsa-miR-549a 435-441 -0.272 94.0 -0.011 37.0 noncon
hsa-miR-943 1389-1395 -0.269 96.0 -0.002 34.0 noncon
hsa-miR-4796-3p 702-708 -0.269 98.0 -0.011 69.0 noncon
hsa-miR-506-5p 1542-1548 -0.268 97.0 -0.002 42.0 noncon
hsa-miR-501-5p 1381-1388 -0.267 96.0 -0.002 31.0 noncon
hsa-miR-3942-3p 1534-1541 -0.263 98.0 -0.002 43.0 noncon
hsa-miR-1264 1028-1035 -0.263 97.0 -0.002 40.0 noncon
hsa-miR-194-3p 359-365 -0.262 96.0 -0.046 76.0 noncon
hsa-miR-4765 855-861 -0.259 96.0 -0.002 29.0 noncon
hsa-miR-1244 24-30 -0.256 94.0 -0.256 96.0 noncon
hsa-miR-6822-3p 207-213 -0.255 94.0 -0.25 95.0 noncon
hsa-miR-4699-5p 76-82 -0.255 96.0 -0.255 97.0 noncon
hsa-miR-3159 1562-1568 -0.254 97.0 -0.002 26.0 noncon
hsa-miR-15b-3p 168-174 -0.252 97.0 -0.247 98.0 noncon