EnzFunc

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Pathway Map
GFPT2



General Information
Gene Symbol:   
GFPT2
Protein name:   
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2
Enzyme Class:   
CAZy Family:   
E.C. No:   
2.6.1.16
Tissues:   
all, Muscular, Epithelial, Connective, Nervous
Organs:   
Reaction (SNFG):   

Fruc(6P) → GlcN(6P)
Reaction (IUBMB):   
No specified reaction.
About

Related Pathway
KEGG ORTHOLOGY:   
KEGG Pathway:   
No Record 
Reactome:   
R-HSA-446210
Related Database
Organism:   
Homo sapiens
Uniprot:   
O94808 
NCBI GeneID:   
9945
GlyMap GeneID:   
9945
DNA aRefSeq:   
NM_005110.3 
Protein RefSeq:   
NP_005101.1 
BRENDA:   
Kinetic info.
OMIM number:   
603865
GeneCards database:   
GFPT2
Enzyme Specificity
Glycan Type:  
     
Compartment:  
     
Substrate:  
     Fruc(6P)
Product:  
     GlcN(6P)
Constraints:  
     None
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 20 10 0 RPKM
Expression Data in Cells {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 60 50 40 30 20 10 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
No high degree of confidence data
miRNA-GlycoEnzyme Interactome {ref. 9}
miRNA Name Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
hsa-miR-153-3p 830-837 -0.538 99.0 -0.538 99.0 con
hsa-miR-676-3p 841-848 -0.512 99.0 -0.512 99.0 noncon
hsa-miR-197-5p 142-149 -0.451 97.0 -0.451 98.0 noncon
hsa-miR-4695-5p 591-598 -0.436 99.0 -0.436 99.0 noncon
hsa-miR-3132 142-149 -0.406 96.0 -0.406 97.0 noncon
hsa-miR-27b-3p 287-294 -0.4 98.0 -0.4 99.0 con
hsa-miR-27a-3p 287-294 -0.4 98.0 -0.4 99.0 con
hsa-miR-383-5p.1 684-691 -0.383 97.0 -0.383 98.0 noncon
hsa-miR-1249-5p 656-663 -0.377 98.0 -0.377 98.0 noncon
hsa-miR-567 854-861 -0.358 98.0 -0.358 98.0 noncon
hsa-miR-4279 200-207 -0.357 98.0 -0.357 98.0 noncon
hsa-miR-367-3p 256-263 -0.356 97.0 -0.356 98.0 con
hsa-miR-6797-5p 656-663 -0.353 97.0 -0.353 98.0 noncon
hsa-miR-25-3p 256-263 -0.351 97.0 -0.351 98.0 con
hsa-miR-1229-5p 143-150 -0.35 98.0 -0.35 98.0 noncon
hsa-miR-5011-3p 762-769 -0.348 98.0 -0.348 99.0 noncon
hsa-miR-363-3p 256-263 -0.348 97.0 -0.348 98.0 con
hsa-miR-32-5p 256-263 -0.338 97.0 -0.338 97.0 con
hsa-miR-92b-3p 256-263 -0.33 97.0 -0.33 98.0 con
hsa-miR-92a-3p 256-263 -0.33 97.0 -0.33 98.0 con
hsa-miR-378b 601-607 -0.328 97.0 -0.328 98.0 noncon
hsa-miR-2355-3p 842-848 -0.317 95.0 -0.317 96.0 noncon
hsa-miR-5701 844-851 -0.313 98.0 -0.313 98.0 noncon
hsa-miR-6730-5p 28-35 -0.311 98.0 -0.311 98.0 noncon
hsa-miR-6856-5p 526-533 -0.309 98.0 -0.309 98.0 noncon
hsa-miR-5703 664-671 -0.309 97.0 -0.309 98.0 noncon
hsa-miR-1245b-3p 33-40 -0.308 98.0 -0.308 98.0 noncon
hsa-miR-124-3p.1 136-142 -0.307 95.0 -0.307 97.0 con
hsa-miR-6758-5p 526-533 -0.307 98.0 -0.307 98.0 noncon
hsa-miR-3622a-5p 135-141 -0.301 98.0 -0.301 98.0 noncon
hsa-miR-3654 602-608 -0.298 98.0 -0.298 98.0 noncon
hsa-miR-650 590-596 -0.297 97.0 -0.297 97.0 noncon
hsa-miR-30e-5p 217-224 -0.295 95.0 -0.295 96.0 con
hsa-miR-4298 50-57 -0.291 95.0 -0.291 96.0 noncon
hsa-miR-30c-5p 217-224 -0.287 94.0 -0.287 96.0 con
hsa-miR-3612 590-596 -0.286 96.0 -0.286 97.0 noncon
hsa-miR-4434 664-671 -0.285 97.0 -0.285 97.0 noncon
hsa-miR-30d-5p 217-224 -0.279 94.0 -0.279 96.0 con
hsa-miR-30a-5p 217-224 -0.279 94.0 -0.279 96.0 con
hsa-miR-30b-5p 217-224 -0.279 94.0 -0.279 95.0 con
hsa-miR-3151-3p 230-237 -0.278 94.0 -0.278 95.0 noncon
hsa-miR-4714-5p 279-286 -0.277 97.0 -0.277 97.0 noncon
hsa-miR-498 750-757 -0.276 98.0 -0.276 99.0 noncon
hsa-miR-6515-5p 657-663 -0.276 94.0 -0.276 95.0 noncon
hsa-miR-6837-5p 705-711 -0.274 94.0 -0.274 95.0 noncon
hsa-miR-378i 601-607 -0.273 95.0 -0.273 96.0 noncon
hsa-miR-4685-5p 705-711 -0.27 94.0 -0.27 95.0 noncon
hsa-miR-4654 91-98 -0.267 95.0 -0.267 97.0 noncon
hsa-miR-1302 50-57 -0.262 93.0 -0.262 95.0 noncon
hsa-miR-422a 601-607 -0.262 94.0 -0.262 96.0 noncon
hsa-miR-378f 601-607 -0.262 94.0 -0.262 96.0 noncon
hsa-miR-378e 601-607 -0.262 94.0 -0.262 96.0 noncon
hsa-miR-378d 601-607 -0.262 94.0 -0.262 96.0 noncon
hsa-miR-378c 601-607 -0.262 94.0 -0.262 96.0 noncon
hsa-miR-378a-3p 601-607 -0.262 94.0 -0.262 96.0 noncon
hsa-miR-4695-5p 619-625 -0.254 95.0 -0.254 96.0 noncon
hsa-miR-487b-5p 301-308 -0.253 97.0 -0.253 98.0 noncon
hsa-miR-1289 504-510 -0.253 90.0 -0.253 93.0 noncon
hsa-miR-378h 601-607 -0.251 94.0 -0.251 95.0 noncon