EnzFunc

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Pathway Map
PGM1



General Information
Gene Symbol:   
PGM1
Protein name:   
Phosphoglucomutase-1
Enzyme Class:   
CAZy Family:   
E.C. No:   
5.4.2.2
Organs:   
Reaction (SNFG):   

Glc(1P) or Glc(6P) → Glc(6P) or Glc(1P)
Reaction (IUBMB):   
No specified reaction.
About

• Phosphoglucomutase 1 moves phosphate from the 1 carbon to the 6 carbon on glucose 1 phosphate. Plays a role in glycolysis.
• Deficiencies in this enzyme causes cardiomyopathy and hepatopathies.

Related Pathway
KEGG ORTHOLOGY:   
KEGG Pathway:   
No Record 
Reactome:   
R-HSA-3322077
Related Database
Organism:   
Homo sapiens
Uniprot:   
P36871 
NCBI GeneID:   
5236
GlyMap GeneID:   
5236
DNA aRefSeq:   
NM_001172818.1 
Protein RefSeq:   
NP_001166289.1 
BRENDA:   
Kinetic info.
OMIM number:   
171900
GeneCards database:   
PGM1
Enzyme Specificity
Glycan Type:  
     
Compartment:  
     
Substrate:  
     Glc(1P) or Glc(6P)
Product:  
     Glc(6P) or Glc(1P)
Constraints:  
     None
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 80 60 40 20 0 RPKM
Expression Data in Cells {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 200 180 160 140 120 100 80 60 40 20 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
No high degree of confidence data
miRNA-GlycoEnzyme Interactome {ref. 9}
miRNA Name Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
hsa-miR-6795-5p 398-405 -0.702 99.0 -0.702 99.0 noncon
hsa-miR-6887-5p 398-405 -0.702 99.0 -0.702 99.0 noncon
hsa-miR-21-5p 560-567 -0.62 99.0 -0.111 87.0 noncon
hsa-miR-590-5p 560-567 -0.544 99.0 -0.1 90.0 noncon
hsa-miR-142-3p.1 286-293 -0.493 98.0 -0.493 98.0 noncon
hsa-miR-4520-3p 452-459 -0.493 99.0 -0.493 99.0 noncon
hsa-miR-767-5p 365-372 -0.463 99.0 -0.463 99.0 noncon
hsa-miR-4317 353-360 -0.432 98.0 -0.432 98.0 noncon
hsa-miR-3137 491-498 -0.427 99.0 -0.421 99.0 noncon
hsa-miR-7109-5p 399-405 -0.427 97.0 -0.427 98.0 noncon
hsa-miR-4733-5p 542-549 -0.423 99.0 -0.417 99.0 noncon
hsa-miR-124-3p.1 445-451 -0.423 98.0 -0.423 99.0 con
hsa-miR-3064-3p 350-357 -0.404 96.0 -0.404 97.0 noncon
hsa-miR-432-3p 41-48 -0.395 98.0 -0.395 98.0 noncon
hsa-miR-5186 209-216 -0.394 99.0 -0.394 99.0 noncon
hsa-miR-449b-5p 150-157 -0.388 95.0 -0.388 97.0 con
hsa-miR-34c-5p 150-157 -0.372 95.0 -0.372 96.0 con
hsa-miR-449a 150-157 -0.37 95.0 -0.37 96.0 con
hsa-miR-3606-5p 114-121 -0.363 97.0 -0.363 98.0 noncon
hsa-miR-4253 226-232 -0.362 94.0 -0.362 96.0 noncon
hsa-miR-4666a-5p 416-423 -0.36 98.0 -0.36 98.0 noncon
hsa-miR-6862-5p 226-232 -0.358 94.0 -0.358 96.0 noncon
hsa-miR-4312 144-151 -0.357 98.0 -0.357 99.0 noncon
hsa-miR-6847-5p 469-476 -0.35 98.0 -0.345 99.0 noncon
hsa-miR-34a-5p 150-157 -0.346 94.0 -0.346 96.0 con
hsa-miR-4743-3p 69-76 -0.344 99.0 -0.344 99.0 noncon
hsa-miR-215-3p 67-74 -0.338 98.0 -0.338 98.0 noncon
hsa-miR-30e-5p 411-418 -0.335 96.0 -0.335 97.0 con
hsa-miR-30a-5p 411-418 -0.335 96.0 -0.335 97.0 con
hsa-miR-30d-5p 411-418 -0.335 96.0 -0.335 97.0 con
hsa-miR-1257 526-533 -0.335 98.0 -0.33 98.0 noncon
hsa-miR-5579-3p 561-567 -0.33 98.0 -0.064 72.0 noncon
hsa-miR-8075 313-320 -0.324 95.0 -0.324 97.0 noncon
hsa-miR-1302 521-527 -0.305 95.0 -0.301 97.0 noncon
hsa-miR-30b-5p 411-418 -0.303 95.0 -0.303 96.0 con
hsa-miR-30c-5p 411-418 -0.303 95.0 -0.303 96.0 con
hsa-miR-6797-5p 24-31 -0.285 95.0 -0.285 96.0 noncon
hsa-miR-4425 424-430 -0.281 91.0 -0.281 94.0 noncon
hsa-miR-4298 521-527 -0.28 94.0 -0.276 96.0 noncon
hsa-miR-4428 261-268 -0.275 97.0 -0.275 98.0 noncon
hsa-miR-6814-5p 168-175 -0.272 97.0 -0.272 98.0 noncon
hsa-miR-6878-3p 327-333 -0.271 94.0 -0.271 96.0 noncon
hsa-miR-1249-5p 24-31 -0.269 93.0 -0.269 95.0 noncon
hsa-miR-3616-3p 228-234 -0.261 90.0 -0.261 92.0 noncon
hsa-miR-1245b-3p 50-57 -0.257 97.0 -0.257 97.0 noncon
hsa-miR-605-3p 446-452 -0.256 92.0 -0.256 94.0 noncon
hsa-miR-4779 230-236 -0.251 95.0 -0.251 96.0 noncon