EnzFunc

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Pathway Map
UGP2



General Information
Gene Symbol:   
UGP2
Protein name:   
UTP--glucose-1-phosphate uridylyltransferase
Enzyme Class:   
CAZy Family:   
E.C. No:   
2.7.7.9
Tissues:   
all, Muscular, Epithelial, Connective, Nervous
Organs:   
Reaction (SNFG):   

Glc(1P) → UDP-Glc
Reaction (IUBMB):   
No specified reaction.
About

• UTP-glucose-1-phosphate uridinylyl transferase creates UDP-glucose from UTP and glucose-1-phosphate.
• Deficient activity of this enzyme in the brain causes epilleptic encephalopathy.

Related Pathway
KEGG ORTHOLOGY:   
KEGG Pathway:   
No Record 
Reactome:   
R-HSA-173599
Related Database
Organism:   
Homo sapiens
Uniprot:   
Q16851 
NCBI GeneID:   
7360
GlyMap GeneID:   
7360
DNA aRefSeq:   
NM_001001521.1 
Protein RefSeq:   
NP_001001521.1 
BRENDA:   
Kinetic info.
OMIM number:   
191750
GeneCards database:   
UGP2
Enzyme Specificity
Glycan Type:  
     
Compartment:  
     
Substrate:  
     Glc(1P)
Product:  
     UDP-Glc
Constraints:  
     None
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
No expression data available.
Expression Data in Cells {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 160 140 120 100 80 60 40 20 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
No high degree of confidence data
miRNA-GlycoEnzyme Interactome {ref. 9}
miRNA Name Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
hsa-miR-367-3p 221-228 -0.668 99.0 -0.668 99.0 con
hsa-miR-32-5p 221-228 -0.666 99.0 -0.666 99.0 con
hsa-miR-4418 133-140 -0.663 99.0 -0.663 99.0 noncon
hsa-miR-363-3p 221-228 -0.66 99.0 -0.66 99.0 con
hsa-miR-25-3p 221-228 -0.655 99.0 -0.655 99.0 con
hsa-miR-92b-3p 221-228 -0.634 99.0 -0.634 99.0 con
hsa-miR-92a-3p 221-228 -0.634 99.0 -0.634 99.0 con
hsa-miR-509-5p 133-140 -0.618 99.0 -0.618 99.0 noncon
hsa-miR-509-3-5p 133-140 -0.618 99.0 -0.618 99.0 noncon
hsa-miR-4325 219-226 -0.576 99.0 -0.576 99.0 noncon
hsa-miR-3977 326-333 -0.53 99.0 -0.442 99.0 noncon
hsa-miR-3188 274-281 -0.519 99.0 -0.519 99.0 noncon
hsa-miR-5008-3p 159-166 -0.518 99.0 -0.518 99.0 noncon
hsa-miR-6737-3p 159-166 -0.513 99.0 -0.513 99.0 noncon
hsa-miR-7157-3p 159-166 -0.505 99.0 -0.505 99.0 noncon
hsa-miR-3925-5p 54-61 -0.485 99.0 -0.485 99.0 noncon
hsa-miR-6513-5p 196-203 -0.438 99.0 -0.438 99.0 noncon
hsa-miR-520h 290-297 -0.433 99.0 -0.433 99.0 noncon
hsa-miR-520g-3p 290-297 -0.433 99.0 -0.433 99.0 noncon
hsa-miR-1245a 287-293 -0.379 99.0 -0.379 99.0 noncon
hsa-miR-4637 204-210 -0.37 98.0 -0.37 99.0 noncon
hsa-miR-8079 287-293 -0.364 99.0 -0.364 99.0 noncon
hsa-miR-1304-5p 276-282 -0.355 97.0 -0.355 98.0 noncon
hsa-miR-6515-3p 188-195 -0.342 98.0 -0.342 99.0 noncon
hsa-miR-6747-3p 74-80 -0.339 98.0 -0.339 98.0 noncon
hsa-miR-6772-3p 168-174 -0.329 96.0 -0.329 97.0 noncon
hsa-miR-5089-5p 195-202 -0.323 99.0 -0.323 99.0 noncon
hsa-miR-548k 80-87 -0.307 99.0 -0.307 99.0 noncon
hsa-miR-7158-3p 207-213 -0.304 99.0 -0.304 99.0 noncon
hsa-miR-137 329-335 -0.303 93.0 0.0 20.0 noncon
hsa-miR-548av-5p 80-87 -0.299 99.0 -0.299 99.0 noncon
hsa-miR-802 92-98 -0.297 97.0 -0.297 98.0 noncon
hsa-miR-181b-3p 323-329 -0.292 97.0 -0.292 98.0 noncon
hsa-miR-181b-2-3p 323-329 -0.292 97.0 -0.292 98.0 noncon
hsa-miR-5584-3p 259-265 -0.275 98.0 -0.275 98.0 noncon
hsa-miR-3975 275-281 -0.273 98.0 -0.273 98.0 noncon
hsa-miR-3158-5p 132-138 -0.272 97.0 -0.272 98.0 noncon
hsa-miR-6841-5p 98-104 -0.269 91.0 -0.269 94.0 noncon
hsa-miR-6815-3p 272-278 -0.262 93.0 -0.262 95.0 noncon
hsa-miR-6837-3p 324-330 -0.262 95.0 -0.262 97.0 noncon
hsa-miR-7702 148-154 -0.257 93.0 -0.257 96.0 noncon
hsa-miR-218-5p 158-164 -0.25 93.0 -0.25 95.0 noncon