EnzFunc

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Pathway Map
ALG5



General Information
Gene Symbol:   
ALG5
Protein name:   
Dolichyl-phosphate beta-glucosyltransferase
Enzyme Class:   
Glycosyltransferase
CAZy Family:   
GT2
E.C. No:   
2.4.1.117
Organs:   
Reaction (SNFG):   
+ Dol-P →
+ UDP
Reaction (IUBMB):   
No specified reaction.
About

• Involved in the synthesis of Dol-P-Glc, using UDP-Glc as donor

Related Pathway
KEGG ORTHOLOGY:   
KEGG Pathway:   
No Record 
Reactome:   
R-HSA-480985
Related Database
Organism:   
Homo sapiens
Uniprot:   
Q9Y673 
NCBI GeneID:   
29880
GlyMap GeneID:   
29880
DNA aRefSeq:   
NM_001142364.1 
Protein RefSeq:   
NP_001135836.1 
BRENDA:   
Kinetic info.
OMIM number:   
604565
GeneCards database:   
ALG5
Enzyme Specificity
Glycan Type:  
     N-linked
Compartment:  
     ER
Substrate:  
     Dol-P
Product:  
     Glc(a1-?)Dol-P
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 40 30 20 10 0 RPKM
Expression Data in Cells {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 120 100 80 60 40 20 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
No high degree of confidence data
miRNA-GlycoEnzyme Interactome {ref. 9}
miRNA Name Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
hsa-miR-6888-3p 265-272 -0.624 99.0 -0.001 35.0 noncon
hsa-miR-3618 262-269 -0.601 99.0 -0.001 12.0 noncon
hsa-miR-146a-3p 343-350 -0.594 99.0 -0.001 27.0 noncon
hsa-miR-203a-3p.1 42-49 -0.529 99.0 -0.529 99.0 noncon
hsa-miR-508-3p 325-332 -0.529 99.0 -0.001 18.0 noncon
hsa-miR-3688-3p 133-140 -0.509 99.0 -0.012 46.0 noncon
hsa-miR-205-3p 80-87 -0.462 99.0 -0.451 99.0 noncon
hsa-miR-4501 39-45 -0.449 99.0 -0.449 99.0 noncon
hsa-miR-6511b-5p 292-298 -0.443 98.0 -0.001 36.0 noncon
hsa-miR-6811-5p 292-298 -0.436 98.0 -0.001 34.0 noncon
hsa-miR-555 279-285 -0.404 97.0 -0.001 16.0 noncon
hsa-miR-1283 260-267 -0.402 99.0 -0.001 19.0 noncon
hsa-miR-6715b-5p 290-296 -0.399 99.0 -0.001 46.0 noncon
hsa-miR-6083 165-172 -0.391 99.0 -0.007 65.0 noncon
hsa-miR-127-5p 224-230 -0.376 98.0 -0.004 38.0 noncon
hsa-miR-3166 101-107 -0.372 96.0 -0.01 29.0 noncon
hsa-miR-4729 168-175 -0.364 99.0 -0.006 55.0 noncon
hsa-miR-1206 306-312 -0.359 98.0 -0.001 23.0 noncon
hsa-miR-6511a-5p 103-109 -0.341 99.0 -0.009 48.0 noncon
hsa-miR-1910-3p 103-109 -0.337 99.0 -0.009 57.0 noncon
hsa-miR-3117-5p 36-42 -0.331 98.0 -0.331 98.0 noncon
hsa-miR-542-3p 38-44 -0.326 98.0 -0.326 98.0 noncon
hsa-miR-4269 290-296 -0.325 99.0 -0.001 56.0 noncon
hsa-miR-4504 38-44 -0.323 98.0 -0.323 98.0 noncon
hsa-miR-4282 65-72 -0.314 99.0 -0.314 99.0 noncon
hsa-miR-3714 104-110 -0.312 99.0 -0.009 56.0 noncon
hsa-miR-548c-3p 174-181 -0.308 99.0 -0.005 72.0 noncon
hsa-miR-3978 132-138 -0.305 99.0 -0.007 64.0 noncon
hsa-miR-5688 216-222 -0.304 99.0 -0.003 69.0 noncon
hsa-miR-4712-3p 302-308 -0.296 98.0 -0.001 31.0 noncon
hsa-miR-8066 40-46 -0.29 98.0 -0.29 98.0 noncon
hsa-miR-607 54-61 -0.29 99.0 -0.29 99.0 noncon
hsa-miR-4743-3p 266-272 -0.285 98.0 -0.001 44.0 noncon
hsa-miR-216b-5p 346-352 -0.277 97.0 -0.001 31.0 noncon
hsa-miR-548an 105-111 -0.277 97.0 -0.008 36.0 noncon
hsa-miR-4693-3p 301-307 -0.276 93.0 -0.001 18.0 noncon
hsa-miR-6841-5p 281-287 -0.271 91.0 -0.001 17.0 noncon
hsa-miR-495-3p 216-222 -0.261 99.0 -0.003 70.0 noncon
hsa-miR-3144-3p 368-374 -0.26 93.0 -0.001 18.0 noncon
hsa-miR-4703-3p 322-328 -0.254 94.0 -0.001 20.0 noncon