EnzFunc

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Pathway Map
PLOD3



General Information
Gene Symbol:   
PLOD3
Protein name:   
Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3
Enzyme Class:   
Glycosyltransferase
CAZy Family:   
E.C. No:   
1.14.11.4
Organs:   
Reaction (SNFG):   

lysine → 5-hydroxy-lysine
Reaction (IUBMB):   
No specified reaction.
About

• Performs hydroxylation of Lys in collagen X-Lys-Gly sequence, along with other similar enzymes PLOD1 and PLOD2
• Hydroxylation is necessary for glycosylation of collagen
• alpha(1-2)GlcT activity has also been attributed to PLOD3 and this is also necessary for collagen glycosylation

Related Pathway
KEGG ORTHOLOGY:   
KEGG Pathway:   
No Record 
Reactome:   
R-HSA-1650814
Related Database
Organism:   
Homo sapiens
Uniprot:   
O60568 
NCBI GeneID:   
8985
GlyMap GeneID:   
8985
DNA aRefSeq:   
NM_001084.4 
Protein RefSeq:   
NP_001075.1 
BRENDA:   
Kinetic info.
OMIM number:   
603066
GeneCards database:   
PLOD3
Enzyme Specificity
Glycan Type:  
     
Compartment:  
     
Substrate:  
     lysine
Product:  
     5-hydroxy-lysine
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
No expression data available.
Expression Data in Cells
No expression data available.
Transcription factor {ref. 10}
No high degree of confidence data