EnzFunc

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Pathway Map
HYAL1



General Information
Gene Symbol:   
HYAL1
Protein name:   
Hyaluronidase-1
Enzyme Class:   
Glycosidase
CAZy Family:   
GH56
E.C. No:   
3.2.1.35
Organs:   
Reaction (SNFG):   
HYAL1
H2O +
→
+
Reaction (IUBMB):   
No specified reaction.
About

• Hyaluronanidases cleave glycosidic β1-4 linkages between glucuronic acid and N-acetylglucosamine residues in the hyaluronan polymer.
• HYAL1 is primarily thought to be important for degradation in endosomal/lysosomal compartment.
• Evidence is mixed as to the role hyaluronanidases play in the context of promoting cancer. HYAL protein expression has been correlated to cancer survival and disease progression for various cancer types, such as bladder and pancreatic.

Related Pathway
KEGG ORTHOLOGY:   
KEGG Pathway:   
No Record 
Reactome:   
R-HSA-2024101
Related Database
Organism:   
Homo sapiens
Uniprot:   
Q12794 
NCBI GeneID:   
3373
GlyMap GeneID:   
3373
DNA aRefSeq:   
NM_033159.3 
Protein RefSeq:   
NP_149349.2 
BRENDA:   
Kinetic info.
OMIM number:   
607071
GeneCards database:   
HYAL1
Enzyme Specificity
Glycan Type:  
     
Compartment:  
     
Substrate:  
     GlcNAc(b1-4)GlcA(b1-3)
Product:  
     GlcA(b1-3)
Constraints:  
     None
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 30 20 10 0 RPKM
Expression Data in Cells {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 20 10 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
No high degree of confidence data
miRNA-GlycoEnzyme Interactome {ref. 9}
miRNA Name Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
hsa-miR-4515 560-567 -0.524 99.0 -0.524 99.0 noncon
hsa-miR-591 91-98 -0.5 99.0 -0.5 99.0 noncon
hsa-miR-409-5p 519-526 -0.49 98.0 -0.49 98.0 noncon
hsa-miR-6836-5p 527-534 -0.48 98.0 -0.48 99.0 noncon
hsa-miR-6132 527-534 -0.469 98.0 -0.469 99.0 noncon
hsa-miR-203a-5p 188-195 -0.464 98.0 -0.464 99.0 noncon
hsa-miR-6811-3p 125-132 -0.455 99.0 -0.455 99.0 noncon
hsa-miR-6840-5p 483-489 -0.454 96.0 -0.454 97.0 noncon
hsa-miR-103b 379-386 -0.45 98.0 -0.45 98.0 noncon
hsa-miR-4480 230-237 -0.434 99.0 -0.434 99.0 noncon
hsa-miR-6867-3p 446-453 -0.427 98.0 -0.427 99.0 noncon
hsa-miR-766-5p 251-258 -0.42 98.0 -0.42 99.0 noncon
hsa-miR-4693-5p 97-104 -0.407 98.0 -0.407 99.0 noncon
hsa-miR-1236-5p 396-403 -0.406 98.0 -0.406 99.0 noncon
hsa-miR-4685-3p 445-452 -0.384 98.0 -0.384 99.0 noncon
hsa-miR-597-3p 28-34 -0.382 97.0 -0.382 98.0 noncon
hsa-miR-542-5p 331-337 -0.377 96.0 -0.377 97.0 noncon
hsa-miR-4287 445-452 -0.376 98.0 -0.376 99.0 noncon
hsa-miR-182-3p 186-193 -0.365 98.0 -0.365 99.0 noncon
hsa-miR-4433b-3p 501-508 -0.364 98.0 -0.364 99.0 noncon
hsa-miR-4790-3p 202-209 -0.361 98.0 -0.361 99.0 noncon
hsa-miR-24-3p 265-272 -0.342 98.0 -0.342 98.0 noncon
hsa-miR-7704 535-541 -0.335 97.0 -0.335 98.0 noncon
hsa-miR-6733-3p 261-268 -0.332 97.0 -0.332 98.0 noncon
hsa-miR-6867-5p 142-149 -0.325 90.0 -0.325 92.0 noncon
hsa-miR-1915-5p 234-240 -0.32 94.0 -0.32 96.0 noncon
hsa-miR-4536-3p 531-537 -0.32 93.0 -0.32 95.0 noncon
hsa-miR-4288 196-202 -0.304 96.0 -0.304 97.0 noncon
hsa-miR-4498 524-530 -0.301 93.0 -0.301 94.0 noncon
hsa-miR-149-5p 267-273 -0.3 97.0 -0.3 97.0 noncon
hsa-miR-542-3p 121-128 -0.298 97.0 -0.298 98.0 noncon
hsa-miR-661 467-473 -0.292 96.0 -0.292 97.0 noncon
hsa-miR-3915 61-68 -0.292 97.0 -0.292 98.0 noncon
hsa-miR-5002-3p 577-583 -0.291 93.0 -0.291 95.0 noncon
hsa-miR-518c-5p 255-262 -0.289 97.0 -0.289 98.0 noncon
hsa-miR-593-3p 257-264 -0.286 96.0 -0.286 97.0 noncon
hsa-miR-922 546-553 -0.283 99.0 -0.283 99.0 noncon
hsa-miR-670-3p 384-391 -0.275 97.0 -0.275 97.0 noncon
hsa-miR-4764-3p 181-187 -0.27 95.0 -0.27 96.0 noncon
hsa-miR-504-3p 500-506 -0.265 95.0 -0.265 97.0 noncon
hsa-miR-613 208-214 -0.264 94.0 -0.264 96.0 noncon
hsa-miR-4666b 71-77 -0.263 94.0 -0.263 96.0 noncon
hsa-miR-671-5p 58-64 -0.258 93.0 -0.258 95.0 noncon
hsa-miR-4423-3p 314-320 -0.254 92.0 -0.254 95.0 noncon
hsa-miR-632 196-202 -0.253 97.0 -0.253 98.0 noncon
hsa-miR-4740-5p 561-567 -0.252 92.0 -0.252 94.0 noncon
hsa-miR-6808-3p 94-100 -0.251 96.0 -0.251 97.0 noncon
hsa-miR-635 423-429 -0.25 94.0 -0.25 95.0 noncon
hsa-miR-6774-5p 423-429 -0.25 93.0 -0.25 95.0 noncon