EnzFunc

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Pathway Map
UGT2A1



General Information
Gene Symbol:   
UGT2A1
Protein name:   
UDP-glucuronosyltransferase 2A1
Enzyme Class:   
Glycosyltransferase
CAZy Family:   
GT1
E.C. No:   
2.4.1.17
Organs:   
Reaction (SNFG):   
+ R →
+ null
Reaction (IUBMB):   
No specified reaction.
About

Related Pathway
KEGG ORTHOLOGY:   
KEGG Pathway:   
No Record 
Reactome:   
R-HSA-156588
Related Database
Organism:   
Homo sapiens
Uniprot:   
P0DTE4 
NCBI GeneID:   
10941
GlyMap GeneID:   
10941
DNA aRefSeq:   
NM_001252274.2 
Protein RefSeq:   
NP_001239203.2 
BRENDA:   
Kinetic info.
OMIM number:   
604716
GeneCards database:   
UGT2A1
Enzyme Specificity
Glycan Type:  
     
Compartment:  
     
Substrate:  
     R
Product:  
     GlcA(??-?)R
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 4 2 0 RPKM
Expression Data in Cells {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 2 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
No high degree of confidence data
miRNA-GlycoEnzyme Interactome {ref. 9}
miRNA Name Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
hsa-miR-645 157-164 -0.765 99.0 -0.765 99.0 noncon
hsa-miR-510-5p 46-53 -0.608 99.0 -0.608 99.0 noncon
hsa-miR-4759 57-64 -0.584 99.0 -0.584 99.0 noncon
hsa-miR-1231 71-78 -0.573 99.0 -0.573 99.0 noncon
hsa-miR-645 157-164 -0.537 99.0 -0.537 99.0 noncon
hsa-miR-8062 889-896 -0.524 99.0 -0.524 99.0 noncon
hsa-miR-8062 889-896 -0.499 99.0 -0.001 39.0 noncon
hsa-miR-8062 866-873 -0.486 99.0 -0.486 99.0 noncon
hsa-let-7a-2-3p 823-830 -0.483 99.0 -0.483 99.0 noncon
hsa-let-7g-3p 823-830 -0.475 99.0 -0.475 99.0 noncon
hsa-miR-196a-5p 269-276 -0.47 99.0 -0.47 99.0 noncon
hsa-miR-196b-5p 269-276 -0.47 99.0 -0.47 99.0 noncon
hsa-miR-8062 866-873 -0.461 99.0 -0.001 39.0 noncon
hsa-let-7a-2-3p 823-830 -0.458 99.0 -0.001 37.0 noncon
hsa-miR-6128 68-75 -0.457 99.0 -0.457 99.0 noncon
hsa-miR-510-5p 46-53 -0.453 99.0 -0.453 99.0 noncon
hsa-miR-374a-3p 150-157 -0.453 99.0 -0.453 99.0 noncon
hsa-let-7g-3p 823-830 -0.45 99.0 -0.001 38.0 noncon
hsa-miR-196b-5p 269-276 -0.445 98.0 -0.001 21.0 noncon
hsa-miR-196a-5p 269-276 -0.445 98.0 -0.001 22.0 noncon
hsa-miR-4503 858-865 -0.439 99.0 -0.439 99.0 noncon
hsa-miR-4759 57-64 -0.429 99.0 -0.429 99.0 noncon
hsa-miR-4777-5p 782-789 -0.429 99.0 -0.429 99.0 noncon
hsa-miR-4261 110-117 -0.422 99.0 -0.422 99.0 noncon
hsa-miR-4451 130-136 -0.42 97.0 -0.42 98.0 noncon
hsa-miR-1231 71-78 -0.418 99.0 -0.418 99.0 noncon
hsa-miR-6863 96-102 -0.415 97.0 -0.415 97.0 noncon
hsa-miR-4503 858-865 -0.414 99.0 -0.001 19.0 noncon
hsa-miR-139-3p 98-104 -0.412 99.0 -0.412 99.0 noncon
hsa-miR-4777-5p 782-789 -0.404 99.0 -0.001 32.0 noncon
hsa-miR-3674 575-582 -0.392 98.0 -0.001 18.0 noncon
hsa-miR-3117-3p 58-64 -0.375 96.0 -0.375 97.0 noncon
hsa-miR-125b-2-3p 185-192 -0.367 99.0 -0.367 99.0 noncon
hsa-miR-214-3p 224-231 -0.348 98.0 -0.348 99.0 noncon
hsa-miR-125b-2-3p 185-192 -0.342 98.0 -0.001 35.0 noncon
hsa-miR-6863 96-102 -0.331 92.0 -0.331 94.0 noncon
hsa-miR-3664-3p 45-51 -0.329 98.0 -0.329 99.0 noncon
hsa-miR-139-3p 98-104 -0.327 98.0 -0.327 98.0 noncon
hsa-miR-2392 104-110 -0.325 98.0 -0.325 98.0 noncon
hsa-miR-4777-5p 598-605 -0.324 98.0 -0.324 98.0 noncon
hsa-miR-6832-5p 129-135 -0.323 96.0 -0.323 97.0 noncon
hsa-miR-214-3p 224-231 -0.323 98.0 -0.001 36.0 noncon
hsa-miR-4451 130-136 -0.322 94.0 -0.322 95.0 noncon
hsa-miR-30c-2-3p 100-106 -0.314 98.0 -0.314 98.0 noncon
hsa-miR-30c-1-3p 100-106 -0.314 98.0 -0.314 98.0 noncon
hsa-miR-362-5p 262-269 -0.311 98.0 -0.311 98.0 noncon
hsa-miR-6871-5p 101-107 -0.309 97.0 -0.309 98.0 noncon
hsa-miR-216b-3p 548-555 -0.304 97.0 -0.304 98.0 noncon
hsa-miR-4776-3p 37-43 -0.302 96.0 -0.302 97.0 noncon
hsa-miR-6128 68-75 -0.302 98.0 -0.302 99.0 noncon
hsa-miR-380-3p 834-841 -0.301 99.0 -0.301 99.0 noncon
hsa-miR-3169 58-64 -0.3 97.0 -0.3 98.0 noncon
hsa-miR-3674 575-582 -0.299 95.0 -0.299 96.0 noncon
hsa-miR-4777-5p 598-605 -0.299 97.0 -0.001 31.0 noncon
hsa-miR-6831-5p 131-137 -0.298 96.0 -0.298 97.0 noncon
hsa-miR-592 257-264 -0.296 97.0 -0.296 97.0 noncon
hsa-miR-8076 417-424 -0.296 97.0 -0.296 97.0 noncon
hsa-miR-3927-3p 131-137 -0.295 95.0 -0.295 97.0 noncon
hsa-miR-500b-5p 262-269 -0.295 98.0 -0.295 98.0 noncon
hsa-miR-3117-3p 58-64 -0.294 92.0 -0.294 95.0 noncon
hsa-miR-936 147-153 -0.291 95.0 -0.291 96.0 noncon
hsa-miR-6750-3p 189-196 -0.287 99.0 -0.287 99.0 noncon
hsa-miR-362-5p 262-269 -0.286 97.0 -0.001 28.0 noncon
hsa-miR-222-5p 147-153 -0.285 96.0 -0.285 97.0 noncon
hsa-miR-5011-5p 19-26 -0.285 98.0 -0.285 99.0 noncon
hsa-miR-192-3p 36-42 -0.282 97.0 -0.282 98.0 noncon
hsa-miR-216b-3p 548-555 -0.279 97.0 -0.001 33.0 noncon
hsa-miR-6510-5p 223-229 -0.278 96.0 -0.278 97.0 noncon
hsa-miR-380-3p 834-841 -0.276 99.0 -0.001 36.0 noncon
hsa-miR-3619-5p 224-231 -0.274 97.0 -0.274 98.0 noncon
hsa-miR-8076 417-424 -0.271 96.0 -0.001 17.0 noncon
hsa-miR-592 257-264 -0.271 96.0 -0.001 19.0 noncon
hsa-miR-500b-5p 262-269 -0.27 97.0 -0.001 29.0 noncon
hsa-miR-6788-5p 100-106 -0.27 97.0 -0.27 98.0 noncon
hsa-miR-4261 110-117 -0.27 96.0 -0.27 97.0 noncon
hsa-miR-8083 58-64 -0.269 96.0 -0.269 97.0 noncon
hsa-miR-182-5p 921-927 -0.268 93.0 -0.268 95.0 noncon
hsa-miR-6510-5p 223-229 -0.266 95.0 -0.001 32.0 noncon
hsa-miR-875-3p 69-75 -0.264 97.0 -0.264 98.0 noncon
hsa-miR-3653-5p 525-531 -0.263 98.0 -0.263 99.0 noncon
hsa-miR-6750-3p 189-196 -0.262 98.0 -0.001 58.0 noncon
hsa-miR-3606-5p 868-874 -0.261 94.0 -0.261 96.0 noncon
hsa-miR-182-5p 921-927 -0.26 92.0 -0.001 18.0 noncon
hsa-miR-5094 149-155 -0.26 96.0 -0.26 97.0 noncon
hsa-miR-6731-5p 219-225 -0.257 92.0 -0.257 94.0 noncon
hsa-miR-3606-5p 868-874 -0.253 93.0 -0.001 16.0 noncon
hsa-miR-3653-5p 525-531 -0.251 98.0 -0.001 36.0 noncon
hsa-miR-4270 221-227 -0.251 95.0 -0.251 96.0 noncon