EnzFunc

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Pathway Map
UGT2B28



General Information
Gene Symbol:   
UGT2B28
Protein name:   
UDP-glucuronosyltransferase 2B28
Enzyme Class:   
Glycosyltransferase
CAZy Family:   
GT1
E.C. No:   
2.4.1.17
Organs:   
Reaction (SNFG):   
+ R →
+ null
Reaction (IUBMB):   
No specified reaction.
About

• UGTs are glucuronyltransferases involved in the glucuronidation pathway. This involves the addition of glucuronic acid to excretables such as bilirubin, xenobiotics, and drugs. Substrates tend to be lipophilic in nature.
• Glucuronidation is often involved in drug metabolism of substances such as drugs, pollutants, bilirubin, androgens, estrogens, mineralocorticoids, glucocorticoids, fatty acid derivatives, retinoids, and bile acids.

Related Pathway
KEGG ORTHOLOGY:   
KEGG Pathway:   
No Record 
Reactome:   
R-HSA-156588
Related Database
Organism:   
Homo sapiens
Uniprot:   
Q9BY64 
NCBI GeneID:   
54490
GlyMap GeneID:   
54490
DNA aRefSeq:   
NM_001207004.1 
Protein RefSeq:   
NP_001193933.1 
BRENDA:   
Kinetic info.
OMIM number:   
606497
GeneCards database:   
UGT2B28
Enzyme Specificity
Glycan Type:  
     
Compartment:  
     
Substrate:  
     R
Product:  
     GlcA(??-?)R
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 12 10 8 6 4 2 0 RPKM
Expression Data in Cells {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 2 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
No high degree of confidence data
miRNA-GlycoEnzyme Interactome {ref. 9}
miRNA Name Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
hsa-miR-4317 470-477 -0.616 99.0 -0.616 99.0 noncon
hsa-miR-146a-3p 428-435 -0.587 99.0 -0.587 99.0 noncon
hsa-miR-4446-5p 488-495 -0.546 99.0 -0.546 99.0 noncon
hsa-miR-1293 439-446 -0.545 99.0 -0.545 99.0 noncon
hsa-miR-7851-3p 443-450 -0.538 99.0 -0.538 99.0 noncon
hsa-miR-891a-3p 88-95 -0.528 99.0 -0.528 99.0 noncon
hsa-miR-3064-3p 467-474 -0.528 98.0 -0.528 98.0 noncon
hsa-miR-1909-3p 50-57 -0.518 99.0 -0.518 99.0 noncon
hsa-miR-6722-3p 50-57 -0.513 99.0 -0.513 99.0 noncon
hsa-miR-5088-3p 255-262 -0.486 99.0 -0.486 99.0 noncon
hsa-miR-4483 439-446 -0.485 99.0 -0.485 99.0 noncon
hsa-miR-4446-5p 258-265 -0.473 99.0 -0.473 99.0 noncon
hsa-miR-216b-5p 266-273 -0.396 99.0 -0.396 99.0 noncon
hsa-miR-656-3p 502-509 -0.386 99.0 -0.386 99.0 noncon
hsa-miR-3927-3p 401-407 -0.383 98.0 -0.383 98.0 noncon
hsa-miR-4755-5p 257-264 -0.373 98.0 -0.373 99.0 noncon
hsa-miR-5006-3p 257-264 -0.373 98.0 -0.373 99.0 noncon
hsa-miR-211-5p 248-255 -0.371 98.0 -0.371 98.0 noncon
hsa-miR-6829-5p 119-125 -0.365 97.0 -0.365 98.0 noncon
hsa-miR-6831-5p 401-407 -0.364 98.0 -0.364 98.0 noncon
hsa-miR-204-5p 248-255 -0.355 98.0 -0.355 98.0 noncon
hsa-miR-758-3p 206-213 -0.351 98.0 -0.351 99.0 noncon
hsa-miR-6832-3p 247-254 -0.337 98.0 -0.337 98.0 noncon
hsa-miR-3064-3p 184-191 -0.329 95.0 -0.329 96.0 noncon
hsa-miR-6813-5p 48-54 -0.296 95.0 -0.296 97.0 noncon
hsa-miR-183-3p 24-31 -0.295 99.0 -0.295 99.0 noncon
hsa-miR-627-3p 341-348 -0.293 98.0 -0.293 98.0 noncon
hsa-miR-3119 509-515 -0.282 95.0 -0.282 97.0 noncon
hsa-miR-599 17-23 -0.28 98.0 -0.28 98.0 noncon
hsa-miR-6085 48-54 -0.278 94.0 -0.278 96.0 noncon
hsa-miR-5583-5p 270-277 -0.276 99.0 -0.276 99.0 noncon
hsa-miR-3129-3p 270-277 -0.276 99.0 -0.276 99.0 noncon
hsa-miR-513a-5p 372-378 -0.272 97.0 -0.272 98.0 noncon
hsa-miR-624-3p 404-410 -0.256 96.0 -0.256 97.0 noncon
hsa-miR-6742-3p 442-448 -0.254 97.0 -0.254 97.0 noncon