EnzFunc

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Pathway Map
UGT2B4



General Information
Gene Symbol:   
UGT2B4
Protein name:   
UDP-glucuronosyltransferase 2B4
Enzyme Class:   
Glycosyltransferase
CAZy Family:   
GT1
E.C. No:   
2.4.1.17
Organs:   
Reaction (SNFG):   
+ R →
+ null
Reaction (IUBMB):   
No specified reaction.
About

• UGTs are glucuronyltransferases involved in the glucuronidation pathway. This involves the addition of glucuronic acid to excretables such as bilirubin, xenobiotics, and drugs. Substrates tend to be lipophilic in nature.
• Glucuronidation is often involved in drug metabolism of substances such as drugs, pollutants, bilirubin, androgens, estrogens, mineralocorticoids, glucocorticoids, fatty acid derivatives, retinoids, and bile acids.

Related Pathway
KEGG ORTHOLOGY:   
KEGG Pathway:   
No Record 
Reactome:   
R-HSA-156588
Related Database
Organism:   
Homo sapiens
Uniprot:   
P06133 
NCBI GeneID:   
7363
GlyMap GeneID:   
7363
DNA aRefSeq:   
NM_001297615.1 
Protein RefSeq:   
NP_001284544.1 
BRENDA:   
Kinetic info.
OMIM number:   
600067
GeneCards database:   
UGT2B4
Enzyme Specificity
Glycan Type:  
     
Compartment:  
     
Substrate:  
     R
Product:  
     GlcA(??-?)R
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 280 260 240 220 200 180 160 140 120 100 80 60 40 20 0 RPKM
Expression Data in Cells {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 2 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
No high degree of confidence data
miRNA-GlycoEnzyme Interactome {ref. 9}
miRNA Name Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
hsa-miR-135b-5p 217-224 -0.502 99.0 -0.502 99.0 noncon
hsa-miR-135a-5p 217-224 -0.486 99.0 -0.486 99.0 noncon
hsa-miR-8077 387-394 -0.478 99.0 -0.478 99.0 noncon
hsa-miR-649 278-285 -0.47 99.0 -0.47 99.0 noncon
hsa-miR-4446-5p 196-203 -0.459 99.0 -0.459 99.0 noncon
hsa-miR-6516-3p 284-291 -0.438 99.0 -0.438 99.0 noncon
hsa-miR-7977 19-26 -0.431 99.0 -0.431 99.0 noncon
hsa-miR-4697-3p 357-364 -0.423 98.0 -0.423 98.0 noncon
hsa-miR-4728-3p 389-396 -0.417 99.0 -0.417 99.0 noncon
hsa-miR-1284 466-473 -0.4 98.0 -0.001 14.0 noncon
hsa-miR-496.1 384-391 -0.363 97.0 -0.363 98.0 noncon
hsa-miR-6839-3p 25-32 -0.361 97.0 -0.361 98.0 noncon
hsa-miR-4776-3p 3613-3620 -0.355 97.0 -0.001 27.0 noncon
hsa-miR-643 75-82 -0.321 97.0 -0.321 98.0 noncon
hsa-miR-7162-5p 443-449 -0.318 96.0 -0.318 97.0 noncon
hsa-miR-1277-5p 1176-1183 -0.315 99.0 -0.001 44.0 noncon
hsa-miR-4657 2893-2900 -0.315 97.0 -0.001 16.0 noncon
hsa-miR-188-3p 4418-4425 -0.315 94.0 -0.001 21.0 noncon
hsa-miR-6874-3p 3408-3415 -0.313 98.0 -0.001 38.0 noncon
hsa-miR-183-5p.2 3420-3427 -0.312 95.0 -0.001 23.0 noncon
hsa-miR-1251-5p 3328-3335 -0.308 96.0 -0.001 32.0 noncon
hsa-miR-3622b-5p 1567-1574 -0.307 96.0 -0.001 28.0 noncon
hsa-miR-4520-3p 4929-4936 -0.3 96.0 -0.001 27.0 noncon
hsa-miR-4491 2893-2900 -0.299 96.0 -0.001 16.0 noncon
hsa-miR-516b-3p 443-449 -0.296 96.0 -0.296 97.0 noncon
hsa-miR-516a-3p 443-449 -0.296 96.0 -0.296 97.0 noncon
hsa-miR-363-5p 1310-1317 -0.295 95.0 -0.001 14.0 noncon
hsa-miR-6505-3p 350-356 -0.288 94.0 -0.288 96.0 noncon
hsa-miR-3171 3938-3945 -0.286 94.0 -0.001 15.0 noncon
hsa-miR-99a-3p 247-253 -0.283 98.0 -0.283 98.0 noncon
hsa-miR-138-2-3p 5062-5069 -0.281 99.0 -0.001 54.0 noncon
hsa-miR-148b-5p 3408-3415 -0.278 98.0 -0.001 35.0 noncon
hsa-miR-944 455-462 -0.277 99.0 -0.277 99.0 noncon
hsa-miR-101-3p.1 371-377 -0.276 96.0 -0.276 97.0 noncon
hsa-miR-6073 3238-3245 -0.273 95.0 -0.001 16.0 noncon
hsa-miR-4691-5p 183-189 -0.273 97.0 -0.273 98.0 noncon
hsa-miR-642a-3p 5015-5021 -0.271 96.0 -0.001 26.0 noncon
hsa-miR-642b-3p 5015-5021 -0.271 96.0 -0.001 26.0 noncon
hsa-miR-190b 3623-3630 -0.271 94.0 -0.001 19.0 noncon
hsa-miR-6883-3p 195-201 -0.269 95.0 -0.269 97.0 noncon
hsa-miR-3688-5p 4528-4534 -0.268 94.0 -0.001 16.0 noncon
hsa-miR-4638-3p 3117-3123 -0.266 93.0 -0.001 17.0 noncon
hsa-miR-6745 1310-1317 -0.266 94.0 -0.001 12.0 noncon
hsa-miR-8058 352-358 -0.262 94.0 -0.262 96.0 noncon
hsa-miR-653-3p 605-612 -0.259 97.0 -0.001 45.0 noncon
hsa-miR-152-5p 2626-2633 -0.257 92.0 -0.001 20.0 noncon
hsa-miR-190a-5p 3623-3630 -0.255 93.0 -0.001 20.0 noncon
hsa-miR-5009-5p 352-358 -0.254 93.0 -0.254 95.0 noncon
hsa-miR-6866-5p 948-954 -0.254 90.0 -0.001 22.0 noncon
hsa-miR-660-3p 182-188 -0.254 96.0 -0.254 97.0 noncon
hsa-miR-2054 52-59 -0.254 98.0 -0.254 98.0 noncon
hsa-miR-520g-5p 1421-1428 -0.252 93.0 -0.001 26.0 noncon
hsa-miR-6792-3p 183-189 -0.252 93.0 -0.252 95.0 noncon
hsa-miR-631 1960-1966 -0.251 90.0 -0.001 17.0 noncon
hsa-miR-3661 1960-1966 -0.25 90.0 -0.001 19.0 noncon
hsa-miR-4709-5p 433-439 -0.25 97.0 -0.25 98.0 noncon
hsa-miR-5006-5p 4706-4712 -0.25 93.0 -0.001 24.0 noncon
hsa-miR-6083 211-218 -0.25 99.0 -0.25 99.0 noncon
hsa-miR-4509 43-49 -0.25 97.0 -0.25 98.0 noncon