EnzFunc

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Pathway Map
PLOD1



General Information
Gene Symbol:   
PLOD1
Protein name:   
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1
Enzyme Class:   
CAZy Family:   
E.C. No:   
1.14.11.4
Organs:   
Reaction (SNFG):   

Lysine → 5-hydroxyl-Lysine
Reaction (IUBMB):   
No specified reaction.
About

• Part of a complex containing PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine in collagen at the sequence X-Lys-Gly
• Hydroxylation is necessary for collagen glycosylation by COLGALT1/2
• Other enzymes facilitating hydroxylation are PLOD2 and PLOD3

Related Pathway
KEGG ORTHOLOGY:   
KEGG Pathway:   
No Record 
Reactome:   
R-HSA-1650814
Related Database
Organism:   
Homo sapiens
Uniprot:   
Q02809 
NCBI GeneID:   
5351
GlyMap GeneID:   
5351
DNA aRefSeq:   
NM_000302.3 
Protein RefSeq:   
NP_000293.2 
BRENDA:   
Kinetic info.
OMIM number:   
153454
GeneCards database:   
PLOD1
Enzyme Specificity
Glycan Type:  
     
Compartment:  
     
Substrate:  
     Lysine
Product:  
     5-hydroxyl-Lysine
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
No expression data available.
Expression Data in Cells
No expression data available.
Transcription factor {ref. 10}
No high degree of confidence data