EnzFunc

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Pathway Map
GMPPB



General Information
Gene Symbol:   
GMPPB
Protein name:   
Mannose-1-phosphate guanyltransferase beta
Enzyme Class:   
N_linked
CAZy Family:   
E.C. No:   
2.7.7.13
Tissues:   
all, Muscular, Epithelial, Connective, Nervous
Organs:   
Reaction (SNFG):   

Man(1P) → GDP-Man
Reaction (IUBMB):   
No specified reaction.
About

• Synthesizes GDP-mannose from mannose 1 phosphate and GTP.
• Knowledge of GMPPA and B is subsumed based on porcupine enzyme activity and the homology of porcupine and GMPPA and B structures.
• GDP-mannose is a critical reactant for sugar nucleotide synthesis and glycosylation, as it can be directly used in the synthesis of N-linked glycans and can be metabolized into other sugar nucleotide donors.

Related Pathway
KEGG ORTHOLOGY:   
KEGG Pathway:   
No Record 
Reactome:   
R-HSA-446205
Related Database
Organism:   
Homo sapiens
Uniprot:   
Q9Y5P6 
NCBI GeneID:   
29925
GlyMap GeneID:   
29925
DNA aRefSeq:   
NM_013334.3 
Protein RefSeq:   
NP_037466.2 
BRENDA:   
Kinetic info.
OMIM number:   
615320
GeneCards database:   
GMPPB
Enzyme Specificity
Glycan Type:  
     
Compartment:  
     
Substrate:  
     Man(1P)
Product:  
     GDP-Man
Constraints:  
     None
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 30 20 10 0 RPKM
Expression Data in Cells {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 80 60 40 20 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
No high degree of confidence data
miRNA-GlycoEnzyme Interactome {ref. 9}
miRNA Name Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
hsa-miR-3944-3p 4631-4638 -0.647 98.0 -0.03 22.0 noncon
hsa-miR-6796-5p 181-188 -0.557 99.0 -0.541 99.0 noncon
hsa-miR-219b-5p 148-155 -0.501 98.0 -0.487 98.0 noncon
hsa-miR-4763-5p 321-328 -0.486 97.0 -0.113 74.0 noncon
hsa-miR-3675-5p 1777-1784 -0.476 99.0 -0.099 83.0 noncon
hsa-miR-6889-5p 1863-1870 -0.471 96.0 -0.023 22.0 noncon
hsa-miR-6777-5p 1863-1870 -0.465 95.0 -0.023 21.0 noncon
hsa-miR-6789-3p 3245-3252 -0.457 96.0 -0.023 34.0 noncon
hsa-miR-6856-3p 219-226 -0.456 99.0 -0.443 99.0 noncon
hsa-miR-574-3p 1187-1194 -0.446 97.0 -0.093 56.0 noncon
hsa-miR-6722-5p 897-904 -0.433 96.0 -0.091 67.0 noncon
hsa-miR-486-3p 1775-1782 -0.432 96.0 -0.091 59.0 noncon
hsa-miR-4649-5p 4325-4332 -0.429 93.0 -0.021 26.0 noncon
hsa-miR-6130 195-202 -0.423 98.0 -0.411 99.0 noncon
hsa-miR-6742-5p 180-187 -0.416 98.0 -0.405 98.0 noncon
hsa-miR-6729-5p 4325-4332 -0.413 93.0 -0.021 26.0 noncon
hsa-miR-187-3p 501-508 -0.409 94.0 -0.097 62.0 noncon
hsa-miR-4510 195-202 -0.407 98.0 -0.396 98.0 noncon
hsa-miR-6129 195-202 -0.407 98.0 -0.396 98.0 noncon
hsa-miR-6133 195-202 -0.407 98.0 -0.396 98.0 noncon
hsa-miR-6127 195-202 -0.407 98.0 -0.396 98.0 noncon
hsa-miR-4520-5p 4428-4435 -0.404 93.0 -0.02 31.0 noncon
hsa-miR-6851-3p 205-212 -0.397 98.0 -0.386 98.0 noncon
hsa-miR-6775-3p 211-218 -0.392 97.0 -0.381 97.0 noncon
hsa-miR-4419a 195-202 -0.391 98.0 -0.38 98.0 noncon
hsa-miR-500b-3p 107-114 -0.389 99.0 -0.389 99.0 noncon
hsa-miR-6886-3p 362-369 -0.38 97.0 -0.091 78.0 noncon
hsa-miR-1972 55-62 -0.374 98.0 -0.374 99.0 noncon
hsa-miR-6075 4828-4834 -0.374 95.0 -0.019 19.0 noncon
hsa-miR-8075 37-44 -0.359 96.0 -0.359 97.0 noncon
hsa-miR-1291 211-218 -0.358 96.0 -0.348 97.0 noncon
hsa-miR-3918 253-260 -0.355 97.0 -0.105 81.0 noncon
hsa-miR-6078 1741-1748 -0.35 97.0 -0.075 64.0 noncon
hsa-miR-6081 4867-4874 -0.339 95.0 -0.017 38.0 noncon
hsa-miR-296-5p 634-641 -0.337 92.0 -0.073 64.0 noncon
hsa-miR-6132 594-601 -0.335 96.0 -0.072 71.0 noncon
hsa-miR-6836-5p 594-601 -0.33 96.0 -0.071 72.0 noncon
hsa-miR-6834-5p 196-203 -0.328 98.0 -0.319 98.0 noncon
hsa-miR-3178 3407-3414 -0.328 94.0 -0.017 30.0 noncon
hsa-miR-1915-5p 325-332 -0.324 94.0 -0.079 72.0 noncon
hsa-miR-6747-5p 178-185 -0.323 96.0 -0.314 97.0 noncon
hsa-miR-3683 2203-2210 -0.317 93.0 -0.016 35.0 noncon
hsa-miR-193b-5p 187-194 -0.316 93.0 -0.308 95.0 noncon
hsa-miR-1271-3p 275-282 -0.307 94.0 -0.075 67.0 noncon
hsa-miR-3194-5p 4714-4721 -0.306 96.0 -0.016 50.0 noncon
hsa-miR-644a 1406-1413 -0.301 94.0 -0.065 75.0 noncon
hsa-miR-6850-3p 3133-3140 -0.301 93.0 -0.016 29.0 noncon
hsa-miR-550a-3-5p 275-282 -0.299 94.0 -0.073 68.0 noncon
hsa-miR-550a-5p 275-282 -0.299 94.0 -0.073 68.0 noncon
hsa-miR-541-3p 1564-1571 -0.296 95.0 -0.064 76.0 noncon
hsa-miR-1288-3p 528-534 -0.296 94.0 -0.064 74.0 noncon
hsa-miR-6827-5p 477-483 -0.296 92.0 -0.073 67.0 noncon
hsa-miR-6894-3p 322-329 -0.295 97.0 -0.072 85.0 noncon
hsa-miR-1227-5p 3542-3549 -0.292 96.0 -0.015 53.0 noncon
hsa-miR-6132 4030-4037 -0.292 94.0 -0.015 43.0 noncon
hsa-miR-6827-5p 299-306 -0.292 91.0 -0.072 67.0 noncon
hsa-miR-324-3p 706-713 -0.289 96.0 -0.063 75.0 noncon
hsa-miR-6836-5p 4030-4037 -0.287 94.0 -0.015 46.0 noncon
hsa-miR-4498 1086-1093 -0.286 91.0 -0.062 59.0 noncon
hsa-miR-550b-2-5p 276-283 -0.283 95.0 -0.07 76.0 noncon
hsa-miR-654-5p 1564-1571 -0.28 94.0 -0.061 75.0 noncon
hsa-miR-5001-5p 1086-1093 -0.28 91.0 -0.061 59.0 noncon
hsa-miR-1914-5p 4008-4015 -0.276 96.0 -0.014 61.0 noncon
hsa-miR-3144-5p 3978-3985 -0.273 90.0 -0.014 34.0 noncon
hsa-miR-4700-3p 1386-1393 -0.272 97.0 -0.06 83.0 noncon
hsa-miR-6756-3p 4589-4596 -0.272 92.0 -0.014 49.0 noncon
hsa-miR-1913 706-713 -0.271 95.0 -0.059 76.0 noncon
hsa-miR-4687-5p 442-449 -0.268 96.0 -0.066 81.0 noncon
hsa-miR-7113-5p 75-81 -0.267 96.0 -0.267 97.0 noncon
hsa-miR-6770-5p 137-144 -0.267 96.0 -0.26 97.0 noncon
hsa-miR-1909-3p 1346-1353 -0.267 92.0 -0.059 66.0 noncon
hsa-miR-4740-5p 1791-1797 -0.265 93.0 -0.058 61.0 noncon
hsa-miR-328-3p 286-292 -0.263 94.0 -0.065 72.0 noncon
hsa-miR-891a-3p 1404-1411 -0.261 95.0 -0.057 76.0 noncon
hsa-miR-4459 4406-4413 -0.258 97.0 -0.014 60.0 noncon
hsa-miR-3127-3p 4589-4596 -0.256 91.0 -0.014 49.0 noncon
hsa-miR-573 1806-1813 -0.256 96.0 -0.056 78.0 noncon
hsa-miR-6890-5p 1778-1784 -0.254 94.0 -0.056 67.0 noncon
hsa-miR-4722-3p 158-165 -0.254 95.0 -0.247 96.0 noncon
hsa-miR-3616-5p 1806-1813 -0.253 96.0 -0.056 76.0 noncon
hsa-miR-7106-3p 371-377 -0.253 92.0 -0.063 65.0 noncon
hsa-miR-3157-3p 364-370 -0.252 95.0 -0.062 73.0 noncon