EnzFunc

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Pathway Map
GALNT18



General Information
Gene Symbol:   
GALNT18
Protein name:   
Polypeptide N-acetylgalactosaminyltransferase 18
Enzyme Class:   
Glycosyltransferase
CAZy Family:   
CBM13
E.C. No:   
2.4.1.41
Organs:   
Reaction (SNFG):   
+ Ser →
+ UDP
+ Thr →
+ UDP
Reaction (IUBMB):   
No specified reaction.
About

• Catalyzes the initiation of O-linked oligosaccharide biosynthesis. Part of the ~20 member ppGalNAcT family.

Related Pathway
KEGG ORTHOLOGY:   
K00710
KEGG Pathway:   
ko00512  ko01100 
Reactome:   
R-HSA-913709
Related Database
Organism:   
Homo sapiens
Uniprot:   
Q6P9A2 
NCBI GeneID:   
374378
GlyMap GeneID:   
374378
DNA aRefSeq:   
NM_198516.2 
Protein RefSeq:   
NP_940918.2 
BRENDA:   
Kinetic info.
OMIM number:   
615136
GeneCards database:   
GALNT18
Enzyme Specificity
Glycan Type:  
     O-linked (mucin type)
Compartment:  
     Cis, Medial, Trans, TGN
Substrate:  
     Ser or Thr
Product:  
     GalNAc(a1-?)Ser or GalNAc(a1-?)Thr
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 6 4 2 0 RPKM
Expression Data in Cells {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 40 30 20 10 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
No high degree of confidence data
miRNA-GlycoEnzyme Interactome {ref. 9}
miRNA Name Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
hsa-miR-223-3p 240-247 -0.638 99.0 -0.638 99.0 con
hsa-miR-5701 244-251 -0.46 99.0 -0.46 99.0 noncon
hsa-miR-144-5p 187-194 -0.42 99.0 -0.42 99.0 noncon
hsa-miR-5585-3p 134-141 -0.403 99.0 -0.403 99.0 noncon
hsa-miR-154-3p 184-191 -0.402 99.0 -0.402 99.0 noncon
hsa-miR-2355-5p 89-96 -0.402 99.0 -0.402 99.0 noncon
hsa-miR-487a-3p 184-191 -0.394 99.0 -0.394 99.0 noncon
hsa-miR-490-3p 97-104 -0.391 99.0 -0.391 99.0 noncon
hsa-miR-4697-5p 109-115 -0.356 96.0 -0.356 97.0 noncon
hsa-miR-6832-3p 264-270 -0.337 98.0 0.0 24.0 noncon
hsa-miR-4488 109-115 -0.332 95.0 -0.332 96.0 noncon
hsa-miR-1237-5p 109-115 -0.328 95.0 -0.328 96.0 noncon
hsa-miR-6884-3p 178-184 -0.3 97.0 -0.3 97.0 noncon
hsa-miR-7109-5p 110-116 -0.3 93.0 -0.3 95.0 noncon
hsa-miR-662 70-76 -0.298 92.0 -0.298 95.0 noncon
hsa-miR-3617-3p 165-171 -0.294 95.0 -0.294 96.0 noncon
hsa-miR-34a-3p 166-172 -0.283 97.0 -0.283 98.0 noncon
hsa-miR-181c-3p 180-186 -0.27 97.0 -0.27 98.0 noncon
hsa-miR-1827 21-27 -0.252 93.0 -0.252 95.0 noncon