EnzFunc

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Pathway Map
GALNT6



General Information
Gene Symbol:   
GALNT6
Protein name:   
Polypeptide N-acetylgalactosaminyltransferase 6
Enzyme Class:   
Glycosyltransferase
CAZy Family:   
CBM13
E.C. No:   
2.4.1.41
Organs:   
Reaction (SNFG):   
+ Ser →
+ UDP
+ Thr →
+ UDP
Reaction (IUBMB):   
No specified reaction.
About

• GALNT6 may participate in synthesis of oncofetal fibronectin.

Related Pathway
KEGG ORTHOLOGY:   
K00710
KEGG Pathway:   
ko00512  ko01100 
Reactome:   
R-HSA-913709
Related Database
Organism:   
Homo sapiens
Uniprot:   
Q8NCL4 
NCBI GeneID:   
11226
GlyMap GeneID:   
11226
DNA aRefSeq:   
NM_007210.3 
Protein RefSeq:   
NP_009141.2 
BRENDA:   
Kinetic info.
OMIM number:   
605148
GeneCards database:   
GALNT6
Enzyme Specificity
Glycan Type:  
     O-linked (mucin type)
Compartment:  
     Cis, Medial, Trans, TGN
Substrate:  
     Ser or Thr
Product:  
     GalNAc(a1-?)Ser or GalNAc(a1-?)Thr
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 30 20 10 0 RPKM
Expression Data in Cells {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 120 100 80 60 40 20 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
Transcriptional start site (TSS) 0 200 -2000 -1800 -1600 -1400 -1200 -1000 -800 -600 -400 -200
ENST00000356317 ENST00000543196 ENST00000603641 RUNX1 RUNX2 ZNF92 ZBTB48 MAX ZNF121 MYC TAL1 ZIM3 ZNF770 FLI1 RUNX1 ATF2 NFE2 ZNF140 RUNX1 KLF5 E2F1 HNF1B TEAD1 IRF1 IRF4 BATF BATF NR5A2 RUNX3 TBX21 TCF3 ETS1 TCF4 IKZF1 TFAP2C STAT5A MECOM MAX ZEB2 BCL11B NFE2 MAX
miRNA-GlycoEnzyme Interactome {ref. 9}
miRNA Name Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
hsa-miR-4497 2440-2447 -0.532 97.0 -0.532 98.0 noncon
hsa-miR-6848-5p 2148-2155 -0.511 97.0 -0.511 98.0 noncon
hsa-miR-4634 1643-1650 -0.501 91.0 -0.501 95.0 noncon
hsa-miR-6846-5p 2148-2155 -0.479 97.0 -0.479 98.0 noncon
hsa-miR-3675-5p 1827-1834 -0.463 99.0 -0.463 99.0 noncon
hsa-miR-6810-5p 2616-2623 -0.449 99.0 -0.024 58.0 noncon
hsa-miR-6846-5p 23-30 -0.442 96.0 -0.442 97.0 noncon
hsa-miR-6848-5p 23-30 -0.434 96.0 -0.434 97.0 noncon
hsa-miR-7160-3p 3033-3040 -0.398 98.0 -0.021 52.0 noncon
hsa-miR-1296-5p 2633-2640 -0.382 94.0 -0.021 34.0 noncon
hsa-miR-6773-5p 161-167 -0.379 97.0 -0.379 98.0 noncon
hsa-miR-585-3p 434-441 -0.375 96.0 -0.375 97.0 noncon
hsa-miR-6812-3p 974-981 -0.36 94.0 -0.36 96.0 noncon
hsa-miR-4437 382-389 -0.357 96.0 -0.357 97.0 noncon
hsa-miR-296-5p 3032-3038 -0.355 93.0 -0.019 38.0 noncon
hsa-miR-6775-3p 1711-1718 -0.354 95.0 -0.354 96.0 noncon
hsa-miR-6724-5p 161-167 -0.354 97.0 -0.354 97.0 noncon
hsa-miR-6827-5p 245-252 -0.347 94.0 -0.347 96.0 noncon
hsa-miR-1205 680-687 -0.328 98.0 -0.328 98.0 noncon
hsa-miR-6842-3p 2383-2390 -0.322 97.0 -0.322 97.0 noncon
hsa-miR-6509-3p 2472-2479 -0.317 97.0 -0.317 98.0 noncon
hsa-miR-1291 1711-1718 -0.312 94.0 -0.312 95.0 noncon
hsa-miR-6895-5p 2632-2639 -0.31 96.0 -0.017 33.0 noncon
hsa-miR-4713-3p 422-429 -0.308 90.0 -0.308 93.0 noncon
hsa-miR-342-5p 955-962 -0.307 94.0 -0.307 96.0 noncon
hsa-miR-4755-3p 2908-2915 -0.303 95.0 -0.017 51.0 noncon
hsa-miR-1270 1686-1693 -0.298 97.0 -0.298 98.0 noncon
hsa-miR-6871-3p 2278-2285 -0.298 96.0 -0.298 97.0 noncon
hsa-miR-6882-3p 2900-2907 -0.296 95.0 -0.016 38.0 noncon
hsa-miR-3116 3123-3129 -0.293 98.0 -0.016 47.0 noncon
hsa-miR-939-3p 385-392 -0.293 96.0 -0.293 97.0 noncon
hsa-miR-6085 1901-1908 -0.286 95.0 -0.286 96.0 noncon
hsa-miR-4472 25-32 -0.283 96.0 -0.283 97.0 noncon
hsa-miR-4447 25-32 -0.283 96.0 -0.283 97.0 noncon
hsa-miR-4540 2215-2222 -0.282 93.0 -0.282 95.0 noncon
hsa-miR-620 1686-1693 -0.279 97.0 -0.279 98.0 noncon
hsa-miR-6813-5p 1901-1908 -0.273 94.0 -0.273 96.0 noncon
hsa-miR-3665 678-685 -0.268 93.0 -0.268 94.0 noncon
hsa-miR-4664-5p 955-962 -0.265 93.0 -0.265 94.0 noncon
hsa-miR-6789-5p 1902-1909 -0.263 92.0 -0.263 94.0 noncon
hsa-miR-4645-5p 2742-2748 -0.262 97.0 -0.015 50.0 noncon
hsa-miR-1254 3123-3129 -0.261 96.0 -0.014 42.0 noncon
hsa-miR-6870-3p 2459-2466 -0.257 96.0 -0.257 97.0 noncon
hsa-miR-6892-3p 1878-1885 -0.253 92.0 -0.253 95.0 noncon
hsa-miR-6748-3p 1883-1889 -0.253 92.0 -0.253 94.0 noncon
hsa-miR-769-5p 2466-2473 -0.252 95.0 -0.252 97.0 noncon
hsa-miR-4489 1826-1832 -0.25 93.0 -0.25 95.0 noncon