EnzFunc

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Pathway Map
PIGC



General Information
Gene Symbol:   
PIGC
Protein name:   
Phosphatidylinositol N-acetylglucosaminyltransferase subunit C
Enzyme Class:   
Glycosyltransferase
CAZy Family:   
E.C. No:   
2.4.1.198
Organs:   
Reaction (SNFG):   

No reaction →
Reaction (IUBMB):   
No specified reaction.
About

• GPI-GnT: GlcNAcT activity that is necessary to form the core glycan structure on GPI-anchored proteins
• Subunit PIGA has catalytic activity, while PIGC, PIGH, PIGQ, PIGP and PIGY have other essential functions
• DPM2 is regulatory and it functions to enhance GPI-GnT activity

Related Pathway
KEGG ORTHOLOGY:   
K03859
KEGG Pathway:   
ko00563  ko01100 
Reactome:   
R-HSA-162710
Related Database
Organism:   
Homo sapiens
Uniprot:   
Q92535 
NCBI GeneID:   
5279
GlyMap GeneID:   
5279
DNA aRefSeq:   
NM_002642.3 
Protein RefSeq:   
NP_002633.1 
BRENDA:   
Kinetic info.
OMIM number:   
601730
GeneCards database:   
PIGC
Enzyme Specificity
Glycan Type:  
     GPI
Compartment:  
     ER
Substrate:  
     No reaction
Product:  
     
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 20 10 0 RPKM
Expression Data in Cells {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 80 60 40 20 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
No high degree of confidence data
miRNA-GlycoEnzyme Interactome {ref. 9}
miRNA Name Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
hsa-miR-4764-5p 265-272 -0.878 99.0 -0.083 69.0 noncon
hsa-miR-4695-5p 43-50 -0.733 99.0 -0.733 99.0 noncon
hsa-miR-4266 44-51 -0.648 99.0 -0.648 99.0 noncon
hsa-miR-7641 116-123 -0.632 99.0 -0.632 99.0 noncon
hsa-miR-148a-5p 59-66 -0.531 99.0 -0.531 99.0 noncon
hsa-miR-659-3p 137-144 -0.518 99.0 -0.518 99.0 noncon
hsa-miR-5007-3p 230-237 -0.485 99.0 -0.485 99.0 noncon
hsa-miR-26a-2-3p 110-117 -0.472 99.0 -0.472 99.0 noncon
hsa-miR-26a-1-3p 110-117 -0.472 99.0 -0.472 99.0 noncon
hsa-miR-2115-5p 84-91 -0.447 98.0 -0.447 99.0 noncon
hsa-miR-1283 181-188 -0.443 99.0 -0.443 99.0 noncon
hsa-miR-6871-3p 159-165 -0.409 98.0 -0.409 99.0 noncon
hsa-miR-3975 41-47 -0.373 99.0 -0.373 99.0 noncon
hsa-miR-2355-5p 201-207 -0.338 98.0 -0.338 98.0 noncon
hsa-miR-3923 51-57 -0.311 96.0 -0.311 97.0 noncon
hsa-miR-1258 46-52 -0.307 93.0 -0.307 95.0 noncon
hsa-miR-3617-3p 31-37 -0.297 95.0 -0.297 97.0 noncon
hsa-miR-6865-3p 157-163 -0.293 95.0 -0.293 97.0 noncon
hsa-miR-4695-3p 116-122 -0.289 96.0 -0.289 97.0 noncon
hsa-miR-3152-3p 262-268 -0.283 96.0 -0.283 97.0 noncon
hsa-miR-3120-3p 222-228 -0.283 98.0 -0.283 98.0 noncon
hsa-miR-3675-3p 114-120 -0.276 98.0 -0.276 99.0 noncon
hsa-miR-499b-3p 238-244 -0.272 97.0 -0.272 98.0 noncon
hsa-miR-499a-3p 238-244 -0.272 97.0 -0.272 98.0 noncon
hsa-miR-1284 55-61 -0.266 93.0 -0.266 95.0 noncon
hsa-miR-6888-3p 68-74 -0.258 95.0 -0.258 97.0 noncon
hsa-miR-140-3p.2 101-107 -0.252 96.0 -0.252 97.0 noncon