EnzFunc

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Pathway Map
CMAS



General Information
Gene Symbol:   
CMAS
Protein name:   
N-acylneuraminate cytidylyltransferase
Enzyme Class:   
CAZy Family:   
E.C. No:   
2.7.7.43
Tissues:   
Muscular, Epithelial, Connective, Nervous
Organs:   
Reaction (SNFG):   

Neu5Ac → CMP-Neu5Ac
Reaction (IUBMB):   
No specified reaction.
About

Related Pathway
KEGG ORTHOLOGY:   
KEGG Pathway:   
No Record 
Reactome:   
R-HSA-4085001
Related Database
Organism:   
Homo sapiens
Uniprot:   
Q8NFW8 
NCBI GeneID:   
55907
GlyMap GeneID:   
55907
DNA aRefSeq:   
NM_018686.5 
Protein RefSeq:   
NP_061156.1 
BRENDA:   
Kinetic info.
OMIM number:   
603316
GeneCards database:   
CMAS
Enzyme Specificity
Glycan Type:  
     N-linked, O-linked (mucin type), O-linked (other), GSL
Compartment:  
     
Substrate:  
     Neu5Ac
Product:  
     CMP-Neu5Ac
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 60 50 40 30 20 10 0 RPKM
Expression Data in Cells {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 120 100 80 60 40 20 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
No high degree of confidence data
miRNA-GlycoEnzyme Interactome {ref. 9}
miRNA Name Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
hsa-miR-200c-5p 312-319 -0.516 99.0 -0.459 99.0 noncon
hsa-miR-550a-3p 312-319 -0.495 99.0 -0.44 99.0 noncon
hsa-miR-3154 322-329 -0.481 99.0 -0.424 99.0 noncon
hsa-miR-6841-5p 238-244 -0.439 98.0 -0.391 98.0 noncon
hsa-miR-4251 183-190 -0.434 99.0 -0.412 99.0 noncon
hsa-miR-4732-5p 131-137 -0.425 98.0 -0.404 99.0 noncon
hsa-miR-7852-3p 338-344 -0.403 98.0 -0.356 98.0 noncon
hsa-miR-603 302-309 -0.398 99.0 -0.356 99.0 noncon
hsa-miR-6504-5p 42-48 -0.398 98.0 -0.398 99.0 noncon
hsa-miR-3064-5p 42-48 -0.387 98.0 -0.387 99.0 noncon
hsa-miR-539-5p 343-350 -0.385 99.0 -0.232 99.0 noncon
hsa-miR-520f-5p 162-169 -0.37 99.0 -0.352 99.0 noncon
hsa-miR-3185 36-43 -0.37 98.0 -0.37 98.0 noncon
hsa-miR-548e-5p 51-58 -0.362 99.0 -0.362 99.0 noncon
hsa-miR-4802-3p 76-82 -0.354 98.0 -0.354 99.0 noncon
hsa-miR-892b 43-49 -0.344 96.0 -0.344 98.0 noncon
hsa-miR-605-5p 280-286 -0.323 99.0 -0.289 99.0 noncon
hsa-miR-4733-5p 278-284 -0.322 98.0 -0.288 98.0 noncon
hsa-miR-2355-5p 294-300 -0.32 97.0 -0.287 97.0 noncon
hsa-miR-4311 141-148 -0.318 99.0 -0.303 99.0 noncon
hsa-miR-4999-5p 29-35 -0.316 95.0 -0.316 97.0 noncon
hsa-miR-4253 318-324 -0.307 91.0 -0.272 92.0 noncon
hsa-miR-4639-3p 95-101 -0.306 98.0 -0.291 98.0 noncon
hsa-miR-6862-5p 318-324 -0.303 91.0 -0.269 92.0 noncon
hsa-miR-203a-3p.1 341-347 -0.303 98.0 -0.269 98.0 con
hsa-miR-3200-5p 185-191 -0.3 98.0 -0.286 98.0 noncon
hsa-miR-6817-3p 93-99 -0.297 98.0 -0.283 98.0 noncon
hsa-miR-4703-3p 337-343 -0.281 95.0 -0.25 95.0 noncon
hsa-miR-2116-5p 208-215 -0.278 99.0 -0.265 99.0 noncon
hsa-miR-323a-3p 84-90 -0.267 98.0 -0.267 99.0 noncon
hsa-miR-6715a-3p 107-113 -0.25 96.0 -0.238 97.0 noncon