EnzFunc

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Pathway Map
ST6GALNAC2



General Information
Gene Symbol:   
ST6GALNAC2
Protein name:   
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
Enzyme Class:   
Glycosyltransferase
CAZy Family:   
GT29
E.C. No:   
2.4.99.3
Organs:   
Reaction (SNFG):   
+
→
+ CMP
Reaction (IUBMB):   
No specified reaction.
About

• ST6GalNAc-II exhibits a narrow substrate specificity for Galβl-3GalNAcal-O-Ser/Thr and Neu5Ac(α2-3)Galβl-3GalNAcαl-O-Ser/Thr substrates, though it may also contribute to the creation of the sialyl-Tn antigen.
• Oligosaccharides and glycosphingolipids did not serve as acceptors for ST6GalNAc-II.
• ST6GalNAc-II is typically expressed at higher levels compared to ST6GalNAc-I. It is highest in lactating mammary gland and adult testis, medium levels in kidney, and only low signals in other tissues.

Related Pathway
KEGG ORTHOLOGY:   
K06616
KEGG Pathway:   
No Record 
Reactome:   
R-HSA-4085001
Related Database
Organism:   
Homo sapiens
Uniprot:   
Q9UJ37 
NCBI GeneID:   
10610
GlyMap GeneID:   
10610
DNA aRefSeq:   
NM_006456.2 
Protein RefSeq:   
NP_006447.2 
BRENDA:   
Kinetic info.
OMIM number:   
610137
GeneCards database:   
ST6GALNAC2
Enzyme Specificity
Glycan Type:  
     O-linked (mucin type)
Compartment:  
     
Substrate:  
     Gal(b1-3)GalNAc(a1-?)Ser|Thr
Product:  
     Gal(b1-3)[NeuAc(a2-6)]GalNAc(a1-?)Ser|Thr
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 30 20 10 0 RPKM
Expression Data in Cells {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 100 80 60 40 20 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
No high degree of confidence data
miRNA-GlycoEnzyme Interactome {ref. 9}
miRNA Name Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
hsa-miR-631 312-319 -0.601 99.0 -0.601 99.0 noncon
hsa-miR-532-3p 459-466 -0.593 99.0 -0.593 99.0 noncon
hsa-miR-1289 392-399 -0.583 99.0 -0.583 99.0 noncon
hsa-miR-3661 312-319 -0.583 99.0 -0.583 99.0 noncon
hsa-miR-6081 444-451 -0.576 99.0 -0.576 99.0 noncon
hsa-miR-588 56-63 -0.555 99.0 -0.555 99.0 noncon
hsa-miR-1288-3p 307-314 -0.544 99.0 -0.544 99.0 noncon
hsa-miR-3605-5p 718-725 -0.529 99.0 -0.13 81.0 noncon
hsa-miR-4701-5p 56-63 -0.523 99.0 -0.523 99.0 noncon
hsa-miR-6809-5p 95-102 -0.517 99.0 -0.517 99.0 noncon
hsa-miR-6802-3p 115-122 -0.497 99.0 -0.497 99.0 noncon
hsa-miR-5001-5p 338-345 -0.484 98.0 -0.484 98.0 noncon
hsa-miR-7155-5p 368-375 -0.475 99.0 -0.475 99.0 noncon
hsa-miR-4713-5p 460-467 -0.461 99.0 -0.461 99.0 noncon
hsa-miR-4498 338-345 -0.442 98.0 -0.442 98.0 noncon
hsa-miR-6747-5p 157-164 -0.433 98.0 -0.433 98.0 noncon
hsa-miR-626 302-309 -0.429 97.0 -0.429 98.0 noncon
hsa-miR-6876-3p 302-309 -0.429 97.0 -0.429 98.0 noncon
hsa-miR-3119 468-475 -0.416 98.0 -0.416 99.0 noncon
hsa-miR-629-3p 461-468 -0.415 99.0 -0.415 99.0 noncon
hsa-miR-3193 555-561 -0.406 95.0 -0.103 71.0 noncon
hsa-miR-1587 339-346 -0.399 98.0 -0.399 98.0 noncon
hsa-miR-4492 338-345 -0.398 98.0 -0.398 98.0 noncon
hsa-miR-96-3p 427-434 -0.394 98.0 -0.394 99.0 noncon
hsa-miR-4793-5p 689-696 -0.388 99.0 -0.099 84.0 noncon
hsa-miR-762 338-345 -0.382 98.0 -0.382 98.0 noncon
hsa-miR-4254 395-402 -0.378 99.0 -0.378 99.0 noncon
hsa-miR-122-3p 730-736 -0.378 96.0 -0.049 49.0 noncon
hsa-miR-1227-3p 356-363 -0.369 96.0 -0.369 97.0 noncon
hsa-miR-4699-5p 82-89 -0.366 98.0 -0.366 99.0 noncon
hsa-miR-548s 221-228 -0.361 99.0 -0.361 99.0 noncon
hsa-miR-556-3p 705-712 -0.355 98.0 -0.091 88.0 noncon
hsa-miR-1255b-5p 177-184 -0.355 97.0 -0.355 97.0 noncon
hsa-miR-1255a 177-184 -0.352 96.0 -0.352 97.0 noncon
hsa-miR-365a-5p 652-659 -0.345 97.0 -0.089 79.0 noncon
hsa-miR-3918 39-46 -0.345 97.0 -0.345 97.0 noncon
hsa-miR-365b-5p 652-659 -0.345 97.0 -0.089 79.0 noncon
hsa-miR-623 226-233 -0.338 98.0 -0.338 99.0 noncon
hsa-miR-4274 238-244 -0.333 98.0 -0.333 98.0 noncon
hsa-miR-3620-5p 339-346 -0.331 98.0 -0.331 98.0 noncon
hsa-miR-3913-3p 694-701 -0.315 95.0 -0.082 67.0 noncon
hsa-miR-4747-5p 90-96 -0.314 96.0 -0.314 97.0 noncon
hsa-miR-6761-5p 581-588 -0.302 98.0 -0.079 85.0 noncon
hsa-miR-3185 23-30 -0.299 97.0 -0.299 97.0 noncon
hsa-miR-5196-5p 90-96 -0.292 95.0 -0.292 96.0 noncon
hsa-miR-371b-3p 108-114 -0.29 94.0 -0.29 96.0 noncon
hsa-miR-6790-3p 137-143 -0.289 97.0 -0.289 98.0 noncon
hsa-miR-4731-5p 160-166 -0.282 96.0 -0.282 97.0 noncon
hsa-miR-4635 26-33 -0.281 98.0 -0.281 99.0 noncon
hsa-miR-3156-3p 458-464 -0.281 96.0 -0.281 97.0 noncon
hsa-miR-4684-5p 537-544 -0.28 98.0 -0.073 84.0 noncon
hsa-miR-5581-3p 569-575 -0.279 96.0 -0.073 83.0 noncon
hsa-miR-4446-5p 228-235 -0.272 97.0 -0.272 98.0 noncon
hsa-miR-8089 369-375 -0.267 94.0 -0.267 96.0 noncon
hsa-miR-212-5p 224-230 -0.264 94.0 -0.264 96.0 noncon
hsa-miR-6894-5p 347-353 -0.261 97.0 -0.261 97.0 noncon
hsa-miR-596 557-563 -0.26 97.0 -0.068 88.0 noncon
hsa-miR-5586-5p 247-253 -0.26 94.0 -0.26 96.0 noncon
hsa-miR-3120-5p 301-307 -0.254 96.0 -0.254 97.0 noncon
hsa-miR-3690 310-316 -0.254 96.0 -0.254 97.0 noncon
hsa-miR-664a-5p 471-477 -0.25 96.0 -0.082 82.0 noncon