EnzFunc

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Pathway Map
IDS



General Information
Gene Symbol:   
IDS
Protein name:   
Iduronate 2-sulfatase
Enzyme Class:   
CAZy Family:   
E.C. No:   
3.1.6.13
Organs:   
Reaction (SNFG):   
→
Reaction (IUBMB):   
No specified reaction.
About

• Iduronic acid sulfatase removes sulfate from iduronic acid on the 2 carbon. Involved in the biosynthesis of dermatan and heparan sulfates.
• Mutations in this gene results in Hunter's Syndrome, which causes accumulation of glycosaminoglycans in the body. The disease manifests early in life and causes a wide array of bodily dysregulation such as joint stiffness, cognitive impairment and neurodegeneration.

Related Pathway
KEGG ORTHOLOGY:   
KEGG Pathway:   
No Record 
Reactome:   
R-HSA-2024096
Related Database
Organism:   
Homo sapiens
Uniprot:   
P22304 
NCBI GeneID:   
3423
GlyMap GeneID:   
3423
DNA aRefSeq:   
NM_000202.7 
Protein RefSeq:   
NP_000193.1 
BRENDA:   
Kinetic info.
OMIM number:   
300823
GeneCards database:   
IDS
Enzyme Specificity
Glycan Type:  
     
Compartment:  
     
Substrate:  
     IdoA(a1-3 S-2)GalNAc(b1-4)
Product:  
     IdoA(a1-3)GalNAc(b1-4)
Constraints:  
     None
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 180 160 140 120 100 80 60 40 20 0 RPKM
Expression Data in Cells {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 140 120 100 80 60 40 20 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
No high degree of confidence data
miRNA-GlycoEnzyme Interactome {ref. 9}
miRNA Name Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
hsa-miR-5088-5p 467-474 -0.664 99.0 -0.613 99.0 noncon
hsa-miR-5088-5p 467-474 -0.62 99.0 -0.578 99.0 noncon
hsa-miR-487b-3p 3784-3791 -0.533 96.0 -0.251 89.0 noncon
hsa-miR-3115 84-91 -0.531 98.0 -0.531 99.0 noncon
hsa-miR-4634 3663-3670 -0.525 92.0 -0.248 83.0 noncon
hsa-miR-4726-5p 724-731 -0.509 98.0 -0.459 98.0 noncon
hsa-miR-1972 141-148 -0.502 99.0 -0.502 99.0 noncon
hsa-miR-487b-3p 3784-3791 -0.486 96.0 -0.234 87.0 noncon
hsa-miR-4640-5p 724-731 -0.483 98.0 -0.436 98.0 noncon
hsa-miR-3115 84-91 -0.479 98.0 -0.479 98.0 noncon
hsa-miR-4687-3p 157-164 -0.468 99.0 -0.468 99.0 noncon
hsa-miR-4726-5p 724-731 -0.465 98.0 -0.424 98.0 noncon
hsa-miR-1972 141-148 -0.449 99.0 -0.449 99.0 noncon
hsa-miR-4687-5p 107-114 -0.446 99.0 -0.446 99.0 noncon
hsa-miR-634 3084-3091 -0.444 99.0 -0.4 99.0 noncon
hsa-miR-4640-5p 724-731 -0.439 97.0 -0.4 97.0 noncon
hsa-miR-4687-3p 157-164 -0.414 98.0 -0.414 98.0 noncon
hsa-miR-539-3p 615-622 -0.412 98.0 -0.383 98.0 noncon
hsa-miR-548u 178-185 -0.408 99.0 -0.408 99.0 noncon
hsa-miR-634 3084-3091 -0.399 98.0 -0.363 98.0 noncon
hsa-miR-3144-5p 2658-2665 -0.397 96.0 -0.361 96.0 noncon
hsa-miR-4687-5p 107-114 -0.393 98.0 -0.393 99.0 noncon
hsa-miR-1226-3p 44-51 -0.393 98.0 -0.393 99.0 noncon
hsa-miR-6862-3p 5526-5533 -0.39 98.0 0.0 0.0 noncon
hsa-miR-675-3p 3347-3354 -0.39 98.0 -0.189 94.0 noncon
hsa-miR-7161-5p 178-185 -0.387 99.0 -0.387 99.0 noncon
hsa-miR-8066 5742-5749 -0.379 99.0 0.0 0.0 noncon
hsa-miR-5193 52-59 -0.378 97.0 -0.378 97.0 noncon
hsa-miR-7152-3p 208-214 -0.374 97.0 -0.348 97.0 noncon
hsa-miR-6825-5p 3934-3941 -0.374 95.0 -0.181 76.0 noncon
hsa-miR-539-3p 615-622 -0.368 97.0 -0.345 97.0 noncon
hsa-miR-4437 466-472 -0.363 97.0 -0.338 97.0 noncon
hsa-miR-6784-3p 5526-5533 -0.361 97.0 0.0 0.0 noncon
hsa-miR-4776-3p 17-24 -0.36 97.0 -0.36 98.0 noncon
hsa-miR-4999-5p 1298-1305 -0.359 96.0 -0.324 97.0 noncon
hsa-miR-6791-3p 909-916 -0.358 98.0 -0.325 98.0 noncon
hsa-miR-6829-3p 909-916 -0.358 98.0 -0.325 98.0 noncon
hsa-miR-873-5p.1 426-433 -0.355 99.0 -0.331 99.0 noncon
hsa-miR-548u 178-185 -0.353 99.0 -0.353 99.0 noncon
hsa-miR-7152-3p 208-214 -0.352 97.0 -0.33 97.0 noncon
hsa-miR-2115-5p 95-102 -0.348 97.0 -0.348 98.0 noncon
hsa-miR-6862-3p 5526-5533 -0.346 96.0 -0.002 41.0 noncon
hsa-miR-675-3p 3347-3354 -0.345 97.0 -0.17 93.0 noncon
hsa-miR-485-3p 615-622 -0.342 98.0 -0.319 98.0 noncon
hsa-miR-7-5p 2515-2521 -0.342 98.0 -0.309 98.0 con
hsa-miR-4437 466-472 -0.341 96.0 -0.32 96.0 noncon
hsa-miR-155-3p 688-695 -0.34 95.0 -0.309 96.0 noncon
hsa-miR-183-5p.2 3255-3262 -0.338 96.0 -0.165 87.0 con
hsa-miR-5004-3p 118-125 -0.336 97.0 -0.336 97.0 noncon
hsa-miR-8066 5742-5749 -0.335 99.0 -0.002 34.0 noncon
hsa-miR-487b-5p 326-333 -0.334 98.0 -0.311 98.0 noncon
hsa-miR-3192-5p 1021-1028 -0.334 98.0 -0.303 98.0 noncon
hsa-miR-4314 1022-1029 -0.332 97.0 -0.301 97.0 noncon
hsa-miR-7161-5p 178-185 -0.332 99.0 -0.332 99.0 noncon
hsa-miR-6763-5p 3935-3942 -0.332 97.0 -0.162 85.0 noncon
hsa-miR-6815-3p 545-552 -0.332 96.0 -0.309 96.0 noncon
hsa-miR-4666a-5p 496-503 -0.331 98.0 -0.308 98.0 noncon
hsa-miR-4999-3p 2381-2388 -0.33 96.0 -0.299 97.0 noncon
hsa-miR-196a-3p 1330-1337 -0.329 96.0 -0.298 96.0 noncon
hsa-miR-198 3943-3950 -0.328 98.0 -0.16 91.0 noncon
hsa-miR-1226-3p 44-51 -0.327 97.0 -0.327 98.0 noncon
hsa-miR-5193 52-59 -0.326 95.0 -0.326 96.0 noncon
hsa-miR-487a-5p 326-333 -0.326 98.0 -0.304 98.0 noncon
hsa-miR-3150a-3p 3935-3942 -0.324 96.0 -0.159 85.0 noncon
hsa-miR-556-5p 1126-1133 -0.323 98.0 -0.293 98.0 noncon
hsa-miR-3144-5p 2658-2665 -0.323 94.0 -0.292 94.0 noncon
hsa-miR-6771-5p 2764-2771 -0.322 91.0 -0.291 91.0 noncon
hsa-miR-5002-5p 645-652 -0.322 98.0 -0.299 98.0 noncon
hsa-miR-6738-3p 913-920 -0.321 97.0 -0.292 97.0 noncon
hsa-miR-4536-5p 4201-4208 -0.32 94.0 0.0 0.0 noncon
hsa-miR-6784-3p 5526-5533 -0.317 96.0 -0.002 38.0 noncon
hsa-miR-3151-5p 2341-2348 -0.316 96.0 -0.286 96.0 noncon
hsa-miR-6825-5p 3934-3941 -0.316 90.0 -0.157 72.0 noncon
hsa-miR-7-5p 2515-2521 -0.316 97.0 -0.288 97.0 con
hsa-miR-4280 5677-5684 -0.315 98.0 0.0 0.0 noncon
hsa-miR-4999-5p 1298-1305 -0.315 95.0 -0.287 96.0 noncon
hsa-miR-6829-3p 909-916 -0.314 97.0 -0.287 98.0 noncon
hsa-miR-6791-3p 909-916 -0.314 97.0 -0.287 98.0 noncon
hsa-miR-4640-3p 3314-3321 -0.312 95.0 -0.153 86.0 noncon
hsa-miR-873-5p.1 426-433 -0.311 99.0 -0.292 99.0 noncon
hsa-miR-517-5p 672-678 -0.31 96.0 -0.285 97.0 noncon
hsa-miR-383-5p.1 2999-3006 -0.309 95.0 -0.28 95.0 noncon
hsa-miR-4776-3p 17-24 -0.308 96.0 -0.308 97.0 noncon
hsa-miR-6873-5p 229-235 -0.306 97.0 -0.285 97.0 noncon
hsa-miR-892b 548-554 -0.306 95.0 -0.285 96.0 noncon
hsa-miR-199a-5p 800-807 -0.304 94.0 -0.276 95.0 noncon
hsa-miR-199b-5p 800-807 -0.304 94.0 -0.276 95.0 noncon
hsa-miR-4700-3p 1216-1223 -0.303 98.0 -0.275 98.0 noncon
hsa-miR-485-3p 615-622 -0.298 97.0 -0.28 98.0 noncon
hsa-miR-2114-3p 4684-4691 -0.297 94.0 0.0 0.0 noncon
hsa-miR-2115-5p 95-102 -0.296 95.0 -0.296 96.0 noncon
hsa-miR-155-3p 688-695 -0.296 93.0 -0.271 94.0 noncon
hsa-miR-517-5p 672-678 -0.295 96.0 -0.274 96.0 noncon
hsa-miR-1253 1150-1157 -0.295 97.0 -0.27 97.0 noncon
hsa-miR-4765 847-854 -0.293 97.0 -0.266 97.0 noncon
hsa-miR-6796-5p 2342-2349 -0.293 93.0 -0.265 93.0 noncon
hsa-miR-4438 1633-1640 -0.291 98.0 -0.264 98.0 noncon
hsa-miR-6844 348-355 -0.291 97.0 -0.271 97.0 noncon
hsa-miR-487b-5p 326-333 -0.29 98.0 -0.273 98.0 noncon
hsa-miR-3192-5p 1021-1028 -0.29 98.0 -0.266 98.0 noncon
hsa-miR-4314 1022-1029 -0.288 95.0 -0.264 96.0 noncon
hsa-miR-6815-3p 545-552 -0.288 94.0 -0.271 95.0 noncon
hsa-miR-4666a-5p 496-503 -0.287 96.0 -0.27 97.0 noncon
hsa-miR-4999-3p 2381-2388 -0.286 94.0 -0.261 95.0 noncon
hsa-miR-196a-3p 1330-1337 -0.285 94.0 -0.26 94.0 noncon
hsa-miR-892b 548-554 -0.284 94.0 -0.267 95.0 noncon
hsa-miR-483-3p.1 55-61 -0.284 96.0 -0.284 97.0 noncon
hsa-miR-6873-5p 229-235 -0.284 96.0 -0.267 96.0 noncon
hsa-miR-4666b 125-131 -0.283 95.0 -0.283 97.0 noncon
hsa-miR-5004-3p 118-125 -0.283 95.0 -0.283 96.0 noncon
hsa-miR-7845-5p 2494-2501 -0.283 94.0 -0.256 95.0 noncon
hsa-miR-487a-5p 326-333 -0.282 98.0 -0.265 98.0 noncon
hsa-miR-619-3p 1273-1280 -0.281 98.0 -0.255 98.0 noncon
hsa-miR-556-5p 1126-1133 -0.279 97.0 -0.256 97.0 noncon
hsa-miR-5002-5p 645-652 -0.278 97.0 -0.261 98.0 noncon
hsa-miR-4732-3p 5505-5512 -0.277 98.0 0.0 0.0 noncon
hsa-miR-6738-3p 913-920 -0.277 95.0 -0.254 96.0 noncon
hsa-miR-5001-3p 912-919 -0.277 95.0 -0.252 96.0 noncon
hsa-miR-4536-5p 4201-4208 -0.276 90.0 -0.002 20.0 noncon
hsa-miR-8061 521-528 -0.276 97.0 -0.257 97.0 noncon
hsa-miR-6808-5p 4145-4152 -0.276 97.0 0.0 0.0 noncon
hsa-miR-6893-5p 4145-4152 -0.276 97.0 0.0 0.0 noncon
hsa-miR-183-5p.2 3255-3262 -0.275 93.0 -0.137 85.0 con
hsa-miR-215-5p 1006-1012 -0.274 97.0 -0.249 97.0 noncon
hsa-miR-6836-3p 910-916 -0.274 95.0 -0.249 96.0 noncon
hsa-miR-6763-5p 3935-3942 -0.273 94.0 -0.137 81.0 noncon
hsa-miR-6757-3p 550-556 -0.271 97.0 -0.253 97.0 noncon
hsa-miR-4760-5p 521-528 -0.271 97.0 -0.253 97.0 noncon
hsa-miR-3151-5p 2341-2348 -0.271 95.0 -0.247 95.0 noncon
hsa-miR-4280 5677-5684 -0.271 97.0 -0.002 38.0 noncon
hsa-miR-192-5p 1006-1012 -0.27 97.0 -0.246 97.0 noncon
hsa-miR-4727-3p 1756-1763 -0.27 90.0 -0.245 92.0 noncon
hsa-miR-1296-3p 1755-1762 -0.268 96.0 -0.243 96.0 noncon
hsa-miR-4640-3p 3314-3321 -0.267 93.0 -0.134 84.0 noncon
hsa-miR-198 3943-3950 -0.266 96.0 -0.133 88.0 noncon
hsa-miR-3150a-3p 3935-3942 -0.265 94.0 -0.133 82.0 noncon
hsa-miR-383-5p.1 2999-3006 -0.265 92.0 -0.242 93.0 noncon
hsa-miR-193b-3p 1069-1075 -0.264 90.0 -0.24 92.0 noncon
hsa-miR-4435 3518-3525 -0.264 94.0 -0.131 86.0 noncon
hsa-miR-6516-3p 2926-2933 -0.263 96.0 -0.238 96.0 noncon
hsa-miR-3926 139-145 -0.262 96.0 -0.262 97.0 noncon
hsa-miR-3675-3p 673-680 -0.262 98.0 -0.242 98.0 noncon
hsa-miR-1178-5p 757-763 -0.26 92.0 -0.237 93.0 noncon
hsa-miR-199b-5p 800-807 -0.26 93.0 -0.238 94.0 noncon
hsa-miR-199a-5p 800-807 -0.26 93.0 -0.238 94.0 noncon
hsa-miR-4688 2625-2631 -0.259 91.0 -0.235 92.0 noncon
hsa-miR-3685 689-696 -0.259 97.0 -0.236 97.0 noncon
hsa-miR-483-3p.1 55-61 -0.258 95.0 -0.258 97.0 noncon
hsa-miR-4700-3p 1216-1223 -0.258 97.0 -0.236 97.0 noncon
hsa-miR-4779 2690-2697 -0.256 95.0 -0.232 95.0 noncon
hsa-miR-4668-5p 4703-4709 -0.256 97.0 0.0 0.0 noncon
hsa-miR-4666b 125-131 -0.256 94.0 -0.256 96.0 noncon
hsa-miR-4764-3p 57-63 -0.254 94.0 -0.254 96.0 noncon
hsa-miR-4503 661-667 -0.253 94.0 -0.236 95.0 noncon
hsa-miR-2114-3p 4684-4691 -0.253 91.0 -0.001 30.0 noncon
hsa-miR-4782-5p 1060-1067 -0.252 96.0 -0.229 96.0 noncon
hsa-miR-6836-3p 910-916 -0.252 94.0 -0.231 95.0 noncon
hsa-miR-6823-3p 4684-4691 -0.252 91.0 0.0 0.0 noncon
hsa-miR-5706 1060-1067 -0.252 96.0 -0.229 96.0 noncon
hsa-miR-3169 2439-2445 -0.251 94.0 -0.228 95.0 noncon
hsa-miR-1306-5p 2360-2367 -0.25 94.0 -0.227 94.0 noncon
hsa-miR-545-5p 257-264 -0.25 97.0 -0.233 97.0 noncon