EnzFunc

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Pathway Map
SULF2



General Information
Gene Symbol:   
SULF2
Protein name:   
Extracellular sulfatase Sulf-2
Enzyme Class:   
CAZy Family:   
E.C. No:   
3.1.6.*
Organs:   
Reaction (SNFG):   
→
Reaction (IUBMB):   
No specified reaction.
About

• Extracellular sulfatases 1 and 2 are secreted proteins that remodel the glycosaminoglycans in the extracellular matrix by removing sulfate groups.
• SULF1 and SULF2 specifically act on GlcNAc 6-sulfate, diminishing the amount of heparan sulfate proteoglycans.
• SULF1 overexpression in ovarian cancer confers cisplatin resistance.

Related Pathway
KEGG ORTHOLOGY:   
KEGG Pathway:   
No Record 
Reactome:   
No Record
Related Database
Organism:   
Homo sapiens
Uniprot:   
Q8IWU5 
NCBI GeneID:   
55959
GlyMap GeneID:   
55959
DNA aRefSeq:   
NM_001161841.1 
Protein RefSeq:   
NP_001155313.1 
BRENDA:   
Kinetic info.
OMIM number:   
610013
GeneCards database:   
SULF2
Enzyme Specificity
Glycan Type:  
     
Compartment:  
     
Substrate:  
     GlcNAc(a1-4 S-6)
Product:  
     GlcNAc(a1-4)
Constraints:  
     None
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 50 40 30 20 10 0 RPKM
Expression Data in Cells {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 600 500 400 300 200 100 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
No high degree of confidence data
miRNA-GlycoEnzyme Interactome {ref. 9}
miRNA Name Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
hsa-miR-6726-3p 347-354 -0.525 97.0 -0.525 98.0 noncon
hsa-miR-3944-5p 233-240 -0.519 99.0 -0.519 99.0 noncon
hsa-miR-616-3p 1513-1520 -0.517 99.0 -0.051 69.0 noncon
hsa-miR-1249-3p 346-353 -0.443 97.0 -0.443 98.0 noncon
hsa-miR-4710 225-232 -0.428 99.0 -0.428 99.0 noncon
hsa-miR-4298 816-823 -0.419 98.0 -0.359 98.0 noncon
hsa-miR-1302 816-823 -0.414 98.0 -0.355 98.0 noncon
hsa-miR-4317 53-60 -0.413 97.0 -0.413 98.0 noncon
hsa-miR-4763-5p 1875-1882 -0.4 95.0 -0.031 51.0 noncon
hsa-miR-637 280-287 -0.394 98.0 -0.394 98.0 noncon
hsa-miR-4515 1258-1265 -0.394 97.0 -0.058 63.0 noncon
hsa-miR-125a-3p 38-45 -0.385 99.0 -0.385 99.0 noncon
hsa-miR-6735-3p 1335-1342 -0.384 98.0 -0.057 72.0 noncon
hsa-miR-3529-5p 1085-1092 -0.383 97.0 -0.056 69.0 noncon
hsa-miR-5698 278-285 -0.382 93.0 -0.382 95.0 noncon
hsa-miR-758-3p 423-430 -0.375 98.0 -0.375 99.0 noncon
hsa-miR-6870-5p 278-285 -0.374 93.0 -0.374 94.0 noncon
hsa-miR-6835-5p 1997-2004 -0.369 96.0 -0.029 29.0 noncon
hsa-miR-4723-5p 278-285 -0.358 92.0 -0.358 93.0 noncon
hsa-miR-4460 268-275 -0.344 94.0 -0.344 96.0 noncon
hsa-miR-138-5p 228-234 -0.342 95.0 -0.342 96.0 con
hsa-miR-7111-5p 278-285 -0.342 91.0 -0.342 93.0 noncon
hsa-miR-4654 2252-2259 -0.342 97.0 -0.027 46.0 noncon
hsa-miR-379-5p 1085-1092 -0.341 96.0 -0.051 69.0 noncon
hsa-miR-4505 891-898 -0.341 97.0 -0.293 96.0 noncon
hsa-miR-6803-5p 1998-2005 -0.338 96.0 -0.026 46.0 noncon
hsa-miR-4792 1548-1555 -0.335 96.0 -0.035 64.0 noncon
hsa-miR-202-3p 222-229 -0.334 96.0 -0.334 97.0 noncon
hsa-miR-3692-5p 80-87 -0.332 98.0 -0.332 98.0 noncon
hsa-miR-193b-5p 887-894 -0.33 93.0 -0.284 94.0 noncon
hsa-miR-6811-3p 49-56 -0.326 97.0 -0.326 98.0 noncon
hsa-miR-4314 762-769 -0.324 97.0 -0.297 97.0 noncon
hsa-miR-6751-5p 1998-2005 -0.317 96.0 -0.025 44.0 noncon
hsa-miR-4712-5p 2241-2248 -0.316 97.0 -0.025 60.0 noncon
hsa-miR-381-5p 697-703 -0.311 92.0 -0.285 92.0 noncon
hsa-miR-6748-5p 1309-1316 -0.31 93.0 -0.047 51.0 noncon
hsa-miR-6503-5p 83-89 -0.309 95.0 -0.309 96.0 noncon
hsa-miR-1269a 1259-1266 -0.302 95.0 -0.046 65.0 noncon
hsa-miR-1269b 1259-1266 -0.302 95.0 -0.046 64.0 noncon
hsa-miR-605-3p 565-572 -0.3 95.0 -0.3 96.0 noncon
hsa-miR-770-5p 2241-2248 -0.3 96.0 -0.024 58.0 noncon
hsa-miR-219b-5p 1950-1957 -0.3 93.0 -0.024 47.0 noncon
hsa-miR-6514-3p 50-57 -0.298 98.0 -0.298 98.0 noncon
hsa-miR-6722-3p 201-207 -0.296 94.0 -0.296 95.0 noncon
hsa-miR-1288-3p 387-393 -0.296 94.0 -0.296 96.0 noncon
hsa-miR-6893-3p 163-170 -0.293 96.0 -0.293 97.0 noncon
hsa-miR-4260 1328-1335 -0.292 94.0 -0.044 65.0 noncon
hsa-miR-2114-5p 1100-1107 -0.288 97.0 -0.044 68.0 noncon
hsa-miR-4769-5p 2252-2259 -0.282 97.0 -0.023 58.0 noncon
hsa-miR-6131 901-908 -0.282 97.0 -0.243 97.0 noncon
hsa-miR-383-5p.2 2170-2176 -0.278 97.0 -0.022 68.0 noncon
hsa-miR-4638-3p 724-731 -0.278 94.0 -0.255 94.0 noncon
hsa-miR-6842-3p 892-899 -0.275 95.0 -0.237 94.0 noncon
hsa-miR-4688 199-205 -0.275 93.0 -0.275 95.0 noncon
hsa-miR-6753-5p 543-549 -0.274 94.0 -0.274 96.0 noncon
hsa-miR-6741-5p 1308-1314 -0.274 97.0 -0.042 80.0 noncon
hsa-miR-6893-3p 2351-2358 -0.274 95.0 -0.022 54.0 noncon
hsa-miR-2682-5p 563-569 -0.273 98.0 -0.273 98.0 noncon
hsa-miR-6509-5p 2370-2377 -0.272 94.0 -0.022 43.0 noncon
hsa-miR-383-5p.1 2169-2175 -0.27 93.0 -0.022 38.0 noncon
hsa-miR-5010-5p 1555-1562 -0.268 92.0 -0.029 38.0 noncon
hsa-miR-193b-3p 677-683 -0.266 90.0 -0.266 94.0 noncon
hsa-miR-193a-3p 677-683 -0.266 90.0 -0.266 94.0 noncon
hsa-miR-4527 83-89 -0.264 93.0 -0.264 95.0 noncon
hsa-miR-4666a-5p 593-600 -0.262 95.0 -0.262 97.0 noncon
hsa-miR-4700-3p 390-396 -0.261 97.0 -0.261 98.0 noncon
hsa-miR-7855-5p 226-232 -0.26 95.0 -0.26 96.0 noncon
hsa-miR-1909-3p 201-207 -0.26 92.0 -0.26 93.0 noncon
hsa-miR-671-5p 1410-1416 -0.257 93.0 -0.039 65.0 noncon
hsa-miR-5787 891-898 -0.255 96.0 -0.22 95.0 noncon
hsa-miR-1294 224-230 -0.255 94.0 -0.255 95.0 noncon
hsa-miR-3913-5p 817-823 -0.255 97.0 -0.22 97.0 noncon
hsa-miR-1302 760-766 -0.254 92.0 -0.234 94.0 noncon
hsa-miR-3167 633-639 -0.254 96.0 -0.254 97.0 noncon
hsa-miR-591 1527-1533 -0.252 90.0 -0.027 49.0 noncon
hsa-miR-4298 760-766 -0.251 92.0 -0.231 93.0 noncon
hsa-miR-3664-3p 1679-1686 -0.25 97.0 -0.027 63.0 noncon