EnzFunc

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Pathway Map
UXS1



General Information
Gene Symbol:   
UXS1
Protein name:   
UDP-glucuronic acid decarboxylase 1
Enzyme Class:   
CAZy Family:   
E.C. No:   
4.1.1.35
Organs:   
Reaction (SNFG):   

UDP-GlcA → UDP-Xyl
Reaction (IUBMB):   
No specified reaction.
About

• UDP-Xylose synthase creates UDP-Xylose from UDP-glucuronic acid.
• Important for the synthesis of dystroglycan, O-linked glucose related glycans, and Glycosaminoglycans.

Related Pathway
KEGG ORTHOLOGY:   
KEGG Pathway:   
No Record 
Reactome:   
No Record
Related Database
Organism:   
Homo sapiens
Uniprot:   
Q8NBZ7 
NCBI GeneID:   
80146
GlyMap GeneID:   
80146
DNA aRefSeq:   
NM_001253875.1 
Protein RefSeq:   
NP_001240804.1 
BRENDA:   
Kinetic info.
OMIM number:   
609749
GeneCards database:   
UXS1
Enzyme Specificity
Glycan Type:  
     GAG
Compartment:  
     Cis, Medial, Trans, TGN
Substrate:  
     UDP-GlcA
Product:  
     UDP-Xyl
Constraints:  
     None
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 30 20 10 0 RPKM
Expression Data in Cells {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 500 400 300 200 100 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
Transcriptional start site (TSS) 0 200 -2000 -1800 -1600 -1400 -1200 -1000 -800 -600 -400 -200
ENST00000409032 ENST00000409501 ENST00000473338 NFE2 CLOCK MAZ STAT5B USF2 SIX5 MYOD1 BATF E2F6 ZBTB33 ZBTB33 KLF1 ZBTB2 YY1 TEAD4 ZNF263 PPARG NFE2 MYC CRY1 RUNX1 MYCN
miRNA-GlycoEnzyme Interactome {ref. 9}
miRNA Name Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
hsa-miR-4708-3p 188-195 -0.622 99.0 -0.622 99.0 noncon
hsa-miR-6734-5p 165-172 -0.579 99.0 -0.579 99.0 noncon
hsa-miR-4423-3p 152-159 -0.572 99.0 -0.572 99.0 noncon
hsa-miR-5195-3p 111-118 -0.566 99.0 -0.566 99.0 con
hsa-miR-18a-3p 466-473 -0.556 99.0 -0.481 99.0 noncon
hsa-miR-22-5p 103-110 -0.553 99.0 -0.553 99.0 noncon
hsa-miR-18b-3p 464-471 -0.548 99.0 -0.475 99.0 noncon
hsa-miR-4646-3p 347-354 -0.547 99.0 -0.538 99.0 noncon
hsa-miR-17-3p 176-183 -0.49 99.0 -0.49 99.0 noncon
hsa-miR-145-5p 111-118 -0.488 99.0 -0.488 99.0 con
hsa-miR-5582-5p 151-158 -0.482 99.0 -0.482 99.0 noncon
hsa-miR-581 17-24 -0.456 99.0 -0.456 99.0 noncon
hsa-miR-500b-5p 583-590 -0.446 99.0 -0.388 99.0 noncon
hsa-miR-362-5p 583-590 -0.43 99.0 -0.375 99.0 noncon
hsa-miR-153-3p 406-412 -0.429 98.0 -0.391 98.0 con
hsa-miR-939-5p 162-168 -0.429 98.0 -0.429 98.0 noncon
hsa-miR-491-3p 409-416 -0.399 97.0 -0.348 97.0 noncon
hsa-miR-1343-5p 162-168 -0.396 98.0 -0.396 98.0 noncon
hsa-miR-6513-3p 35-42 -0.381 99.0 -0.381 99.0 noncon
hsa-miR-7855-5p 709-715 -0.365 98.0 -0.007 41.0 noncon
hsa-miR-342-3p 486-493 -0.358 98.0 -0.313 98.0 noncon
hsa-miR-5003-5p 281-288 -0.358 98.0 -0.353 98.0 noncon
hsa-miR-8062 596-603 -0.356 98.0 -0.287 98.0 noncon
hsa-miR-130a-3p 191-197 -0.355 98.0 -0.355 98.0 con
hsa-miR-6739-3p 105-112 -0.352 98.0 -0.352 98.0 noncon
hsa-miR-4669 15-21 -0.339 99.0 -0.339 99.0 noncon
hsa-miR-4300 161-167 -0.336 96.0 -0.336 97.0 noncon
hsa-miR-5591-5p 161-167 -0.336 95.0 -0.336 96.0 noncon
hsa-miR-6722-5p 447-453 -0.333 90.0 -0.291 92.0 noncon
hsa-miR-130b-3p 191-197 -0.333 97.0 -0.333 98.0 con
hsa-miR-106b-5p 193-199 -0.333 98.0 -0.333 99.0 con
hsa-miR-20a-5p 193-199 -0.333 98.0 -0.333 99.0 con
hsa-miR-106a-5p 193-199 -0.323 98.0 -0.323 99.0 con
hsa-miR-6726-5p 161-167 -0.322 94.0 -0.322 96.0 noncon
hsa-miR-93-5p 193-199 -0.319 98.0 -0.319 99.0 con
hsa-miR-17-5p 193-199 -0.319 98.0 -0.319 98.0 con
hsa-miR-20b-5p 193-199 -0.319 98.0 -0.319 98.0 con
hsa-miR-6813-3p 526-532 -0.317 97.0 -0.278 97.0 noncon
hsa-miR-454-3p 191-197 -0.314 97.0 -0.314 98.0 con
hsa-miR-3666 191-197 -0.311 97.0 -0.311 98.0 con
hsa-miR-301a-3p 191-197 -0.311 97.0 -0.311 98.0 con
hsa-miR-301b-3p 191-197 -0.311 97.0 -0.311 97.0 con
hsa-miR-4295 191-197 -0.311 97.0 -0.311 98.0 con
hsa-miR-4680-3p 512-519 -0.31 99.0 -0.271 98.0 noncon
hsa-miR-7108-3p 625-631 -0.309 90.0 -0.25 88.0 noncon
hsa-miR-3622a-5p 152-158 -0.309 98.0 -0.309 98.0 noncon
hsa-miR-519d-3p 193-199 -0.308 98.0 -0.308 98.0 con
hsa-miR-4714-5p 515-521 -0.307 97.0 -0.269 97.0 noncon
hsa-miR-3684 529-535 -0.303 93.0 -0.266 94.0 noncon
hsa-miR-7153-3p 672-678 -0.298 97.0 -0.24 97.0 noncon
hsa-miR-199b-3p 600-606 -0.294 95.0 -0.238 94.0 con
hsa-miR-199a-3p 600-606 -0.294 95.0 -0.238 94.0 con
hsa-miR-3157-3p 465-471 -0.287 97.0 -0.252 96.0 noncon
hsa-miR-4677-5p 104-111 -0.287 97.0 -0.287 98.0 noncon
hsa-miR-920 161-167 -0.285 96.0 -0.285 96.0 noncon
hsa-miR-6738-5p 165-171 -0.285 96.0 -0.285 96.0 noncon
hsa-miR-4433b-5p 347-353 -0.28 94.0 -0.276 95.0 noncon
hsa-miR-4704-3p 285-291 -0.272 95.0 -0.268 96.0 noncon
hsa-miR-526b-3p 193-199 -0.26 98.0 -0.26 98.0 con
hsa-miR-6830-3p 81-87 -0.26 97.0 -0.26 97.0 noncon
hsa-miR-6793-3p 637-643 -0.255 96.0 -0.207 96.0 noncon