EnzFunc

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Pathway Map
LARGE2



General Information
Gene Symbol:   
LARGE2
Protein name:   
LARGE xylosyl- and glucuronyltransferase 2
Enzyme Class:   
Glycosyltransferase
CAZy Family:   
GT49
E.C. No:   
2.4.*.*
Organs:   
Reaction (SNFG):   
+
→
+ UDP
+
→
+ UDP
+
→
+ UDP
Reaction (IUBMB):   
No specified reaction.
About

• LARGE1 and LARGE2 are bifunctional enzymes with α(1-3)XylT and β(1-3)GlcAT activity
• They extends O-Man structures (core M3) on DAG1

Related Pathway
KEGG ORTHOLOGY:   
K09668
KEGG Pathway:   
No Record 
Reactome:   
R-HSA-5173105
Related Database
Organism:   
Homo sapiens
Uniprot:   
Q8N3Y3 
NCBI GeneID:   
120071
GlyMap GeneID:   
120071
DNA aRefSeq:   
NM_001300721.1 
Protein RefSeq:   
NP_001287650.1 
BRENDA:   
Kinetic info.
OMIM number:   
609709
GeneCards database:   
LARGE2
Enzyme Specificity
Glycan Type:  
     O-linked (other)
Compartment:  
     Cis, Medial, Trans, TGN
Substrate:  
     GlcA(b1-4)Xyl(b1-4) or GlcA(b1-3) or Xyl(a1-?)
Product:  
     Xyl(a1-3)GlcA(b1-4)Xyl(b1-4) or Xyl(a1-3)GlcA(b1-3) or GlcA(b1-3)Xyl(a1-?)
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 40 30 20 10 0 RPKM
Expression Data in Cells
No expression data available.
Transcription factor {ref. 10}
No high degree of confidence data