EnzFunc

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Pathway Map
XXYLT1



General Information
Gene Symbol:   
XXYLT1
Protein name:   
Xyloside xylosyltransferase 1
Enzyme Class:   
Glycosyltransferase
CAZy Family:   
GT8
E.C. No:   
2.4.2.n3
Organs:   
Reaction (SNFG):   
+
→
+ UDP
Reaction (IUBMB):   
No specified reaction.
About

• Adds the 2nd (α1-3)Xyl to extend O-Glc chains in selected proteins that have an EGF domain with consensus sequence C-X-S-X-P/A-C.

Related Pathway
KEGG ORTHOLOGY:   
KEGG Pathway:   
No Record 
Reactome:   
No Record
Related Database
Organism:   
Homo sapiens
Uniprot:   
Q8NBI6 
NCBI GeneID:   
152002
GlyMap GeneID:   
152002
DNA aRefSeq:   
NM_152531.4 
Protein RefSeq:   
NP_689744.3 
BRENDA:   
Kinetic info.
OMIM number:   
614552
GeneCards database:   
XXYLT1
Enzyme Specificity
Glycan Type:  
     O-linked (other)
Compartment:  
     
Substrate:  
     Xyl(a1-3)Glc(b1-?)Ser
Product:  
     Xyl(a1-3)Xyl(a1-3)Glc(b1-?)Ser
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 4 2 0 RPKM
Expression Data in Cells {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 80 60 40 20 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
No high degree of confidence data
miRNA-GlycoEnzyme Interactome {ref. 9}
miRNA Name Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
hsa-miR-23b-5p 1138-1145 -0.489 98.0 -0.489 99.0 noncon
hsa-miR-23a-5p 1138-1145 -0.437 98.0 -0.437 99.0 noncon
hsa-miR-5001-5p 469-476 -0.42 97.0 -0.42 97.0 noncon
hsa-miR-133a-3p.2 352-358 -0.413 96.0 -0.413 97.0 con
hsa-miR-133b 352-358 -0.413 96.0 -0.413 97.0 con
hsa-miR-3621 83-89 -0.413 93.0 -0.413 94.0 noncon
hsa-miR-4498 469-476 -0.402 97.0 -0.402 97.0 noncon
hsa-miR-6774-3p 236-242 -0.402 92.0 -0.402 94.0 noncon
hsa-miR-3065-3p 123-130 -0.383 98.0 -0.383 99.0 noncon
hsa-miR-1236-5p 1184-1191 -0.378 98.0 -0.378 98.0 noncon
hsa-miR-4283 431-438 -0.373 96.0 -0.373 97.0 noncon
hsa-miR-361-3p 36-43 -0.373 98.0 -0.373 98.0 noncon
hsa-miR-2115-5p 2010-2017 -0.358 97.0 -0.001 15.0 noncon
hsa-miR-4450 1227-1233 -0.355 96.0 -0.355 97.0 noncon
hsa-miR-4260 433-440 -0.348 96.0 -0.348 97.0 noncon
hsa-miR-5589-5p 1141-1148 -0.348 99.0 -0.348 99.0 noncon
hsa-miR-99a-5p 440-446 -0.348 90.0 -0.348 93.0 noncon
hsa-miR-5001-5p 500-507 -0.342 95.0 -0.342 96.0 noncon
hsa-miR-544b 2423-2430 -0.337 98.0 -0.001 31.0 noncon
hsa-miR-4281 802-809 -0.336 99.0 -0.336 99.0 noncon
hsa-miR-4492 469-476 -0.334 97.0 -0.334 98.0 noncon
hsa-miR-6079 485-492 -0.333 98.0 -0.333 98.0 noncon
hsa-miR-762 469-476 -0.326 97.0 -0.326 97.0 noncon
hsa-miR-1976 789-796 -0.326 98.0 -0.326 98.0 noncon
hsa-miR-516a-5p 394-400 -0.321 94.0 -0.321 95.0 noncon
hsa-miR-4498 500-507 -0.308 93.0 -0.308 95.0 noncon
hsa-miR-4668-5p 1390-1397 -0.305 98.0 -0.305 98.0 noncon
hsa-miR-6078 223-229 -0.303 95.0 -0.303 97.0 noncon
hsa-miR-1265 676-683 -0.299 97.0 -0.299 98.0 noncon
hsa-miR-8485 2760-2767 -0.298 98.0 0.0 0.0 noncon
hsa-miR-4438 852-859 -0.294 98.0 -0.294 98.0 noncon
hsa-miR-6756-3p 282-289 -0.292 93.0 -0.292 95.0 noncon
hsa-miR-3690 1038-1045 -0.288 97.0 -0.288 97.0 noncon
hsa-miR-3127-3p 282-289 -0.284 93.0 -0.284 95.0 noncon
hsa-miR-642a-3p 2745-2751 -0.276 97.0 -0.001 27.0 noncon
hsa-miR-642b-3p 2745-2751 -0.276 97.0 -0.001 27.0 noncon
hsa-miR-1251-5p 88-95 -0.276 95.0 -0.276 97.0 noncon
hsa-miR-6750-3p 2671-2678 -0.271 98.0 -0.001 59.0 noncon
hsa-miR-3127-5p 1736-1743 -0.268 93.0 -0.001 25.0 noncon
hsa-miR-502-5p 1628-1635 -0.267 95.0 -0.001 38.0 noncon
hsa-miR-4492 500-507 -0.264 95.0 -0.264 96.0 noncon
hsa-miR-6731-3p 2349-2355 -0.263 95.0 -0.001 37.0 noncon
hsa-miR-6895-3p 92-99 -0.263 95.0 -0.263 96.0 noncon
hsa-miR-7106-3p 217-224 -0.262 92.0 -0.262 95.0 noncon
hsa-miR-585-5p 2442-2448 -0.261 91.0 -0.001 14.0 noncon
hsa-miR-1200 2424-2431 -0.258 96.0 -0.001 36.0 noncon
hsa-miR-762 500-507 -0.256 93.0 -0.256 95.0 noncon
hsa-miR-1915-3p 519-526 -0.256 97.0 -0.256 98.0 noncon
hsa-miR-6734-3p 40-47 -0.253 93.0 -0.253 95.0 noncon
hsa-miR-7151-3p 853-860 -0.251 94.0 -0.251 96.0 noncon
hsa-miR-6748-3p 45-51 -0.251 92.0 -0.251 94.0 noncon
hsa-miR-6764-5p 519-526 -0.251 97.0 -0.251 97.0 noncon