FuncClass

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Pathway Map
GLA



General Information
Gene Symbol:   
GLA
Protein name:   
Alpha-galactosidase A
Enzyme Class:   
Glycosidase
CAZy Family:   
GH27
E.C. No:   
3.2.1.22
Organs:   
Reaction (SNFG):   
GLA
H2O +
→
+
Reaction (IUBMB):   
No specified reaction.
About

• Alpha-galactosidase A hydrolyzes of GSLs in lysosomes.
• Sphingolipid activator protein B (SAP-B) is required for alpha galactosidase A to function in lysosomes

Related Pathway
KEGG ORTHOLOGY:   
KEGG Pathway:   
No Record 
Reactome:   
R-HSA-1660662
Related Database
Organism:   
Homo sapiens
Uniprot:   
P06280 
NCBI GeneID:   
2717
GlyMap GeneID:   
2717
DNA aRefSeq:   
NM_000169.2 
Protein RefSeq:   
NP_000160.1 
BRENDA:   
Kinetic info.
OMIM number:   
300644
GeneCards database:   
GLA
Enzyme Specificity
Glycan Type:  
     
Compartment:  
     
Substrate:  
     Gal(a1-?)Gal
Product:  
     Gal(a1-?)
Constraints:  
     None
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 30 20 10 0 RPKM
Expression Data in Cells {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 300 200 100 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
No high degree of confidence data
miRNA-GlycoEnzyme Interactome {ref. 9}
miRNA Name Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
hsa-miR-4715-5p 16-23 -0.845 99.0 -0.031 60.0 noncon
hsa-miR-4707-3p 113-120 -0.529 94.0 -0.005 17.0 noncon
hsa-miR-512-5p 1301-1308 -0.52 99.0 -0.005 50.0 noncon
hsa-miR-1256 1661-1668 -0.512 99.0 -0.005 31.0 noncon
hsa-miR-4763-5p 406-413 -0.432 96.0 -0.004 29.0 noncon
hsa-miR-5095 83-90 -0.421 99.0 -0.004 45.0 noncon
hsa-miR-7151-3p 83-90 -0.41 99.0 -0.004 46.0 noncon
hsa-miR-561-5p 657-664 -0.402 98.0 -0.004 28.0 noncon
hsa-miR-8071 33-39 -0.396 98.0 -0.004 39.0 noncon
hsa-miR-2682-3p 1156-1163 -0.383 98.0 -0.004 36.0 noncon
hsa-miR-1255b-5p 718-725 -0.377 97.0 -0.004 30.0 noncon
hsa-miR-1255a 718-725 -0.374 97.0 -0.004 28.0 noncon
hsa-miR-6781-3p 1156-1163 -0.362 98.0 -0.004 35.0 noncon
hsa-miR-3115 707-713 -0.357 95.0 -0.004 23.0 noncon
hsa-miR-3621 145-151 -0.353 90.0 -0.004 15.0 noncon
hsa-miR-4425 1242-1249 -0.349 95.0 -0.003 17.0 noncon
hsa-miR-4763-5p 982-989 -0.347 92.0 -0.003 28.0 noncon
hsa-miR-1244 19-26 -0.345 97.0 -0.003 30.0 noncon
hsa-miR-6511b-5p 1411-1418 -0.341 97.0 -0.003 42.0 noncon
hsa-miR-629-5p 704-711 -0.329 98.0 -0.003 32.0 noncon
hsa-miR-6895-3p 1314-1321 -0.326 97.0 -0.003 44.0 noncon
hsa-miR-8085 751-758 -0.324 96.0 -0.003 29.0 noncon
hsa-miR-1976 542-549 -0.324 98.0 -0.003 56.0 noncon
hsa-miR-1271-3p 359-366 -0.323 95.0 -0.003 25.0 noncon
hsa-miR-584-3p 1147-1153 -0.315 96.0 -0.003 42.0 noncon
hsa-miR-193b-5p 167-174 -0.31 92.0 -0.003 26.0 noncon
hsa-miR-6731-5p 751-758 -0.308 95.0 -0.003 30.0 noncon
hsa-miR-550a-3-5p 359-366 -0.307 94.0 -0.003 26.0 noncon
hsa-miR-550a-5p 359-366 -0.307 94.0 -0.003 26.0 noncon
hsa-miR-7114-5p 1615-1622 -0.3 97.0 -0.003 30.0 noncon
hsa-miR-6830-5p 656-663 -0.3 98.0 -0.003 28.0 noncon
hsa-miR-1273f 334-341 -0.293 97.0 -0.003 44.0 noncon
hsa-miR-744-3p 321-328 -0.29 95.0 -0.003 38.0 noncon
hsa-miR-6811-5p 1411-1418 -0.29 96.0 -0.003 39.0 noncon
hsa-miR-4259 17-23 -0.29 94.0 -0.013 46.0 noncon
hsa-miR-3935 1559-1565 -0.288 95.0 -0.003 21.0 noncon
hsa-miR-122-5p 1104-1111 -0.286 97.0 -0.003 34.0 noncon
hsa-miR-3609 51-58 -0.285 98.0 -0.003 50.0 noncon
hsa-miR-548ah-5p 51-58 -0.282 99.0 -0.003 48.0 noncon
hsa-miR-6732-5p 941-947 -0.281 92.0 -0.003 15.0 noncon
hsa-miR-6778-3p 1041-1048 -0.276 95.0 -0.003 38.0 noncon
hsa-miR-1247-3p 267-273 -0.27 90.0 -0.003 17.0 noncon
hsa-miR-3679-3p 1578-1584 -0.268 92.0 -0.003 42.0 noncon
hsa-miR-1273f 632-639 -0.267 96.0 -0.003 44.0 noncon
hsa-miR-6839-3p 705-711 -0.266 94.0 -0.003 32.0 noncon
hsa-miR-8086 1296-1302 -0.266 90.0 -0.003 24.0 noncon
hsa-miR-6790-3p 900-907 -0.259 96.0 -0.003 35.0 noncon
hsa-miR-4703-3p 18-24 -0.259 94.0 -0.003 27.0 noncon
hsa-miR-4294 627-634 -0.253 93.0 -0.003 32.0 noncon
hsa-miR-1273f 1109-1116 -0.252 96.0 -0.003 44.0 noncon