FuncClass

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Pathway Map
HYAL3



General Information
Gene Symbol:   
HYAL3
Protein name:   
Hyaluronidase-3
Enzyme Class:   
Glycosidase
CAZy Family:   
GH56
E.C. No:   
3.2.1.35
Organs:   
Reaction (SNFG):   
HYAL3
H2O +
→
+
Reaction (IUBMB):   
No specified reaction.
About

• Hyaluronanidases cleave glycosidic β1-4 linkages between glucuronic acid and N-acetylglucosamine residues in the hyaluronan polymer.
• Evidence is mixed as to the role hyaluronanidases play in the context of promoting cancer. HYAL protein expression has been correlated to cancer survival and disease progression for various cancer types, such as bladder and pancreatic.
• HYAL3 does not have significant hyaluronidase activity.

Related Pathway
KEGG ORTHOLOGY:   
KEGG Pathway:   
No Record 
Reactome:   
R-HSA-2024101
Related Database
Organism:   
Homo sapiens
Uniprot:   
O43820 
NCBI GeneID:   
8372
GlyMap GeneID:   
8372
DNA aRefSeq:   
NM_001200029.1 
Protein RefSeq:   
NP_001186958.1 
BRENDA:   
Kinetic info.
OMIM number:   
604038
GeneCards database:   
HYAL3
Enzyme Specificity
Glycan Type:  
     
Compartment:  
     
Substrate:  
     GlcNAc(b1-4)GlcA(b1-3)
Product:  
     GlcA(b1-3)
Constraints:  
     None
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 20 10 0 RPKM
Expression Data in Cells {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 20 10 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
No high degree of confidence data
miRNA-GlycoEnzyme Interactome {ref. 9}
miRNA Name Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
hsa-miR-3177-3p 313-320 -0.592 98.0 -0.592 98.0 noncon
hsa-miR-6883-5p 100-107 -0.551 99.0 -0.551 99.0 noncon
hsa-miR-149-3p 100-107 -0.535 99.0 -0.535 99.0 noncon
hsa-miR-6785-5p 100-107 -0.517 99.0 -0.517 99.0 noncon
hsa-miR-4728-5p 100-107 -0.501 99.0 -0.501 99.0 noncon
hsa-miR-943 92-99 -0.496 99.0 -0.496 99.0 noncon
hsa-miR-1227-5p 331-338 -0.49 99.0 -0.49 99.0 noncon
hsa-miR-3166 375-382 -0.468 98.0 -0.468 99.0 noncon
hsa-miR-7154-3p 199-206 -0.467 99.0 -0.467 99.0 noncon
hsa-miR-1915-5p 208-215 -0.46 98.0 -0.46 98.0 noncon
hsa-miR-4308 222-229 -0.46 99.0 -0.46 99.0 noncon
hsa-miR-4781-5p 116-122 -0.456 95.0 -0.456 96.0 noncon
hsa-miR-4260 332-339 -0.451 98.0 -0.451 98.0 noncon
hsa-miR-30b-3p 101-108 -0.446 99.0 -0.446 99.0 noncon
hsa-miR-1273h-5p 101-108 -0.438 98.0 -0.438 98.0 noncon
hsa-miR-3689b-3p 101-108 -0.43 98.0 -0.43 99.0 noncon
hsa-miR-3689a-3p 101-108 -0.43 98.0 -0.43 99.0 noncon
hsa-miR-3689c 101-108 -0.43 98.0 -0.43 99.0 noncon
hsa-miR-6779-5p 101-108 -0.43 98.0 -0.43 98.0 noncon
hsa-miR-4692 412-418 -0.429 99.0 0.0 29.0 noncon
hsa-miR-34a-5p 410-416 -0.423 97.0 0.0 12.0 noncon
hsa-miR-4514 412-418 -0.419 99.0 0.0 29.0 noncon
hsa-miR-6780a-5p 101-108 -0.417 98.0 -0.417 99.0 noncon
hsa-miR-6806-5p 273-280 -0.416 95.0 -0.416 96.0 noncon
hsa-miR-34c-5p 410-416 -0.413 96.0 0.0 11.0 noncon
hsa-miR-449a 410-416 -0.412 97.0 0.0 12.0 noncon
hsa-miR-3164 396-402 -0.406 98.0 -0.406 99.0 noncon
hsa-miR-449b-5p 410-416 -0.402 96.0 0.0 12.0 noncon
hsa-miR-4515 48-54 -0.394 97.0 -0.394 98.0 noncon
hsa-miR-1272 388-395 -0.39 99.0 -0.39 99.0 noncon
hsa-miR-4648 67-73 -0.387 98.0 -0.387 99.0 noncon
hsa-miR-7113-3p 224-231 -0.386 99.0 -0.386 99.0 noncon
hsa-miR-4695-3p 186-193 -0.384 98.0 -0.384 98.0 noncon
hsa-miR-380-5p 95-101 -0.377 97.0 -0.377 98.0 noncon
hsa-miR-27a-5p 287-294 -0.377 98.0 -0.377 98.0 noncon
hsa-miR-6820-3p 396-402 -0.373 98.0 -0.373 98.0 noncon
hsa-miR-6510-5p 32-38 -0.372 98.0 -0.372 99.0 noncon
hsa-miR-516b-3p 212-219 -0.36 97.0 -0.36 98.0 noncon
hsa-miR-516a-3p 212-219 -0.36 97.0 -0.36 98.0 noncon
hsa-miR-885-3p 36-42 -0.354 98.0 -0.354 99.0 noncon
hsa-miR-636 106-113 -0.353 98.0 -0.353 98.0 noncon
hsa-miR-921 282-289 -0.34 97.0 -0.34 98.0 noncon
hsa-miR-29b-1-5p 171-178 -0.336 98.0 -0.336 98.0 noncon
hsa-miR-7162-5p 212-219 -0.336 97.0 -0.336 98.0 noncon
hsa-miR-34b-5p 411-417 -0.335 99.0 0.0 0.0 noncon
hsa-miR-563 95-101 -0.334 95.0 -0.334 97.0 noncon
hsa-miR-5582-5p 271-278 -0.33 97.0 -0.33 98.0 noncon
hsa-miR-4745-5p 69-75 -0.328 95.0 -0.328 96.0 noncon
hsa-miR-4481 69-75 -0.321 97.0 -0.321 97.0 noncon
hsa-miR-4659a-5p 205-212 -0.318 97.0 -0.318 98.0 noncon
hsa-miR-502-5p 209-216 -0.318 97.0 -0.318 98.0 noncon
hsa-miR-6821-3p 298-305 -0.318 97.0 -0.318 98.0 noncon
hsa-miR-6075 310-316 -0.317 91.0 -0.317 93.0 noncon
hsa-miR-449c-5p 411-417 -0.313 98.0 0.0 0.0 noncon
hsa-miR-34a-5p 16-22 -0.313 92.0 -0.313 94.0 noncon
hsa-miR-2682-5p 411-417 -0.31 98.0 0.0 0.0 noncon
hsa-miR-449b-5p 16-22 -0.303 91.0 -0.303 93.0 noncon
hsa-miR-449a 16-22 -0.302 91.0 -0.302 94.0 noncon
hsa-miR-6762-5p 331-337 -0.301 91.0 -0.301 93.0 noncon
hsa-miR-128-1-5p 331-337 -0.297 95.0 -0.297 96.0 noncon
hsa-miR-4659b-5p 205-212 -0.297 96.0 -0.297 97.0 noncon
hsa-miR-874-5p 149-155 -0.296 93.0 -0.296 94.0 noncon
hsa-miR-3148 404-411 -0.294 99.0 -0.294 99.0 noncon
hsa-miR-34c-5p 16-22 -0.292 90.0 -0.292 93.0 noncon
hsa-miR-1302 66-72 -0.288 95.0 -0.288 96.0 noncon
hsa-miR-214-3p 33-39 -0.281 97.0 -0.281 98.0 noncon
hsa-miR-4298 66-72 -0.274 94.0 -0.274 96.0 noncon
hsa-miR-1827 18-24 -0.273 94.0 -0.273 96.0 noncon
hsa-miR-7641 187-193 -0.267 96.0 -0.267 97.0 noncon
hsa-miR-3136-5p 93-99 -0.264 95.0 -0.264 96.0 noncon
hsa-miR-4423-3p 272-278 -0.263 93.0 -0.263 95.0 noncon
hsa-miR-3190-5p 151-157 -0.262 96.0 -0.262 97.0 noncon
hsa-miR-3169 49-55 -0.26 95.0 -0.26 96.0 noncon
hsa-miR-3619-5p 33-39 -0.258 97.0 -0.258 97.0 noncon
hsa-miR-6747-5p 113-119 -0.251 93.0 -0.251 95.0 noncon
hsa-miR-585-5p 363-369 -0.25 90.0 -0.25 93.0 noncon