FuncClass

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Pathway Map
HYAL4



General Information
Gene Symbol:   
HYAL4
Protein name:   
Hyaluronidase-4
Enzyme Class:   
Glycosidase
CAZy Family:   
GH56
E.C. No:   
3.2.1.35
Organs:   
Reaction (SNFG):   
HYAL4
H2O +
→
+
Reaction (IUBMB):   
No specified reaction.
About

• Hyaluronanidases cleave glycosidic β1-4 linkages between glucuronic acid and N-acetylglucosamine residues in the hyaluronan polymer.
• HYAL4 appears to act physiologically as a chondroitinase also.

Related Pathway
KEGG ORTHOLOGY:   
KEGG Pathway:   
No Record 
Reactome:   
No Record
Related Database
Organism:   
Homo sapiens
Uniprot:   
Q2M3T9 
NCBI GeneID:   
23553
GlyMap GeneID:   
23553
DNA aRefSeq:   
NM_012269.2 
Protein RefSeq:   
NP_036401.2 
BRENDA:   
Kinetic info.
OMIM number:   
604510
GeneCards database:   
HYAL4
Enzyme Specificity
Glycan Type:  
     
Compartment:  
     
Substrate:  
     GlcNAc(b1-4)GlcA(b1-3)
Product:  
     GlcA(b1-3)
Constraints:  
     None
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 2 0 RPKM
Expression Data in Cells {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 4 2 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
No high degree of confidence data
miRNA-GlycoEnzyme Interactome {ref. 9}
miRNA Name Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
hsa-miR-934 109-116 -0.631 99.0 -0.631 99.0 noncon
hsa-miR-891b 229-236 -0.6 99.0 -0.6 99.0 noncon
hsa-miR-7154-5p 267-274 -0.595 99.0 -0.595 99.0 noncon
hsa-miR-3612 158-165 -0.594 99.0 -0.594 99.0 noncon
hsa-miR-650 158-165 -0.562 99.0 -0.562 99.0 noncon
hsa-miR-3924 292-299 -0.545 99.0 -0.545 99.0 noncon
hsa-miR-3173-3p 210-217 -0.538 99.0 -0.538 99.0 noncon
hsa-miR-6891-5p 210-217 -0.528 99.0 -0.528 99.0 noncon
hsa-miR-181b-5p 271-278 -0.425 98.0 -0.425 99.0 noncon
hsa-miR-181c-5p 271-278 -0.425 98.0 -0.425 99.0 noncon
hsa-miR-181d-5p 271-278 -0.425 98.0 -0.425 99.0 noncon
hsa-miR-181a-5p 271-278 -0.425 98.0 -0.425 99.0 noncon
hsa-miR-3924 280-287 -0.416 99.0 -0.416 99.0 noncon
hsa-miR-1248 49-56 -0.415 99.0 -0.415 99.0 noncon
hsa-miR-4717-5p 26-32 -0.392 99.0 -0.392 99.0 noncon
hsa-miR-645 35-41 -0.367 96.0 -0.367 97.0 noncon
hsa-miR-4262 271-278 -0.363 98.0 -0.363 99.0 noncon
hsa-miR-297 278-284 -0.354 97.0 -0.354 98.0 noncon
hsa-miR-4443 159-165 -0.336 96.0 -0.336 97.0 noncon
hsa-miR-568 290-296 -0.326 98.0 -0.326 99.0 noncon
hsa-miR-3938 16-22 -0.326 97.0 -0.326 98.0 noncon
hsa-miR-3177-5p 201-207 -0.321 91.0 -0.321 94.0 noncon
hsa-miR-3923 248-254 -0.311 96.0 -0.311 97.0 noncon
hsa-miR-6866-5p 29-35 -0.31 94.0 -0.31 96.0 noncon
hsa-miR-4755-5p 15-21 -0.309 98.0 -0.309 98.0 noncon
hsa-miR-5006-3p 15-21 -0.309 98.0 -0.309 98.0 noncon
hsa-miR-4652-3p 138-145 -0.307 99.0 -0.307 99.0 noncon
hsa-miR-548u 261-267 -0.301 98.0 -0.301 99.0 noncon
hsa-miR-3618 110-116 -0.294 90.0 -0.294 93.0 noncon
hsa-miR-766-5p 208-214 -0.275 95.0 -0.275 96.0 noncon
hsa-miR-33a-3p 143-150 -0.27 99.0 -0.27 99.0 noncon
hsa-miR-493-5p 274-280 -0.26 97.0 -0.26 98.0 noncon
hsa-miR-7161-5p 261-267 -0.26 98.0 -0.26 98.0 noncon
hsa-miR-567 278-284 -0.252 95.0 -0.252 97.0 noncon
hsa-miR-623 15-21 -0.25 96.0 -0.25 97.0 noncon