FuncClass

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Pathway Map
MAN2B1



General Information
Gene Symbol:   
MAN2B1
Protein name:   
Lysosomal alpha-mannosidase
Enzyme Class:   
Glycosidase
CAZy Family:   
GH38
E.C. No:   
3.2.1.24
Organs:   
Reaction (SNFG):   

Man(a1-?) → ...
Reaction (IUBMB):   
No specified reaction.
About

• Cleaves all known types of alpha-mannosidic linkages during N-glycan degradation in lysosome

Related Pathway
KEGG ORTHOLOGY:   
KEGG Pathway:   
No Record 
Reactome:   
R-HSA-6798695
Related Database
Organism:   
Homo sapiens
Uniprot:   
O00754 
NCBI GeneID:   
4125
GlyMap GeneID:   
4125
DNA aRefSeq:   
NM_000528.3 
Protein RefSeq:   
NP_000519.2 
BRENDA:   
Kinetic info.
OMIM number:   
609458
GeneCards database:   
MAN2B1
Enzyme Specificity
Glycan Type:  
     N-linked
Compartment:  
     
Substrate:  
     Man(a1-?)
Product:  
     ...
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
No expression data available.
Expression Data in Cells {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 140 120 100 80 60 40 20 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
No high degree of confidence data
miRNA-GlycoEnzyme Interactome {ref. 9}
miRNA Name Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
hsa-miR-924 101-108 -0.653 99.0 -0.61 99.0 noncon
hsa-miR-4670-5p 109-115 -0.526 95.0 -0.002 21.0 noncon
hsa-miR-4704-3p 118-125 -0.449 99.0 -0.002 41.0 noncon
hsa-miR-1203 37-43 -0.432 95.0 -0.432 96.0 noncon
hsa-miR-5197-5p 80-87 -0.419 99.0 -0.419 99.0 noncon
hsa-miR-6774-5p 24-30 -0.359 97.0 -0.359 98.0 noncon
hsa-miR-1244 95-101 -0.354 97.0 -0.354 98.0 noncon
hsa-miR-6515-5p 16-23 -0.343 97.0 -0.343 97.0 noncon
hsa-miR-4527 46-53 -0.308 95.0 -0.308 96.0 noncon
hsa-miR-6503-5p 46-53 -0.302 95.0 -0.302 96.0 noncon
hsa-miR-635 24-30 -0.293 96.0 -0.293 97.0 noncon
hsa-miR-324-3p 43-50 -0.292 96.0 -0.292 97.0 noncon
hsa-miR-4695-5p 30-36 -0.292 96.0 -0.292 97.0 noncon
hsa-miR-627-5p 102-108 -0.291 97.0 -0.274 98.0 noncon
hsa-miR-5702 58-64 -0.285 94.0 -0.285 96.0 noncon
hsa-miR-1913 43-50 -0.274 95.0 -0.274 96.0 noncon
hsa-miR-411-5p.2 96-102 -0.26 95.0 -0.26 96.0 noncon
hsa-miR-885-3p 78-84 -0.258 95.0 -0.258 96.0 noncon