FuncClass

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Pathway Map
B3GNT4



General Information
Gene Symbol:   
B3GNT4
Protein name:   
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 4
Enzyme Class:   
Glycosyltransferase
CAZy Family:   
GT31
E.C. No:   
2.4.1.149
Organs:   
Reaction (SNFG):   
+
→
+ UDP
Reaction (IUBMB):   
No specified reaction.
About

• Weak/no activity for formation of polylactosamine structures based on substrates, though its precise specificity is ill defined.
• Higher expression in brain, kidney and colon.

Related Pathway
KEGG ORTHOLOGY:   
K07971
KEGG Pathway:   
ko00601  ko01100 
Reactome:   
R-HSA-2022854
Related Database
Organism:   
Homo sapiens
Uniprot:   
Q9C0J1 
NCBI GeneID:   
79369
GlyMap GeneID:   
79369
DNA aRefSeq:   
NM_001330492.1 
Protein RefSeq:   
NP_001317421.1 
BRENDA:   
Kinetic info.
OMIM number:   
605864
GeneCards database:   
B3GNT4
Enzyme Specificity
Glycan Type:  
     N-linked, O-linked (mucin type), GSL
Compartment:  
     Cis, Medial, Trans, TGN
Substrate:  
     Gal(b1-?)
Product:  
     GlcNAc(b1-3)Gal(b1-?)
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:    3.70e-06    (pmol/cell • hr)       KM:    7.00e+08    (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 8 6 4 2 0 RPKM
Expression Data in Cells {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 12 10 8 6 4 2 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
No high degree of confidence data
miRNA-GlycoEnzyme Interactome {ref. 9}
miRNA Name Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
hsa-miR-937-3p 1231-1238 -0.569 95.0 -0.455 94.0 noncon
hsa-miR-4732-5p 75-82 -0.533 99.0 -0.533 99.0 noncon
hsa-miR-4785 1022-1029 -0.49 93.0 -0.394 92.0 noncon
hsa-miR-1468-5p 352-359 -0.486 93.0 -0.391 92.0 noncon
hsa-miR-6499-3p 137-144 -0.484 99.0 -0.484 99.0 noncon
hsa-miR-3137 1459-1466 -0.452 99.0 -0.364 98.0 noncon
hsa-miR-6802-3p 763-770 -0.449 98.0 -0.362 97.0 noncon
hsa-miR-3177-3p 1221-1228 -0.433 95.0 -0.349 94.0 noncon
hsa-miR-5591-3p 738-745 -0.416 98.0 -0.336 98.0 noncon
hsa-miR-660-5p 737-744 -0.407 98.0 -0.329 98.0 noncon
hsa-miR-649 643-650 -0.404 99.0 -0.326 98.0 noncon
hsa-miR-1909-5p 837-844 -0.395 97.0 -0.319 97.0 noncon
hsa-miR-3665 1131-1138 -0.393 97.0 -0.318 97.0 noncon
hsa-miR-3907 416-423 -0.387 97.0 -0.313 96.0 noncon
hsa-miR-938 666-673 -0.366 98.0 -0.297 98.0 noncon
hsa-miR-297 530-537 -0.357 97.0 -0.289 97.0 noncon
hsa-miR-324-3p 502-509 -0.357 97.0 -0.289 97.0 noncon
hsa-miR-7107-3p 1476-1482 -0.354 96.0 -0.287 96.0 noncon
hsa-miR-615-5p 276-283 -0.348 95.0 -0.282 94.0 noncon
hsa-miR-4715-5p 89-95 -0.345 96.0 -0.345 97.0 noncon
hsa-miR-3678-3p 1326-1333 -0.342 98.0 -0.278 97.0 noncon
hsa-miR-1913 502-509 -0.339 97.0 -0.275 96.0 noncon
hsa-miR-342-5p 436-442 -0.339 96.0 -0.275 95.0 noncon
hsa-miR-4433b-5p 1201-1208 -0.335 96.0 -0.272 95.0 noncon
hsa-miR-1289 683-689 -0.335 95.0 -0.272 94.0 noncon
hsa-miR-3667-3p 364-371 -0.332 97.0 -0.27 97.0 noncon
hsa-miR-433-3p 1533-1540 -0.328 98.0 -0.266 98.0 noncon
hsa-miR-4777-3p 725-732 -0.327 95.0 -0.266 94.0 noncon
hsa-miR-7851-3p 699-706 -0.325 96.0 -0.264 95.0 noncon
hsa-miR-576-3p 1504-1510 -0.322 98.0 -0.262 97.0 noncon
hsa-miR-6753-3p 1476-1482 -0.321 95.0 -0.261 95.0 noncon
hsa-miR-4650-5p 1175-1182 -0.321 98.0 -0.261 97.0 noncon
hsa-miR-223-3p 1368-1375 -0.315 95.0 -0.256 94.0 noncon
hsa-miR-6852-5p 279-286 -0.31 97.0 -0.252 96.0 noncon
hsa-miR-2278 73-80 -0.295 98.0 -0.295 99.0 noncon
hsa-miR-6777-3p 24-31 -0.295 96.0 -0.295 97.0 noncon
hsa-miR-4664-5p 436-442 -0.294 94.0 -0.239 93.0 noncon
hsa-miR-492 807-814 -0.282 92.0 -0.23 90.0 noncon
hsa-miR-1207-3p 1145-1152 -0.275 97.0 -0.224 96.0 noncon
hsa-miR-6501-3p 124-130 -0.267 97.0 -0.267 98.0 noncon
hsa-miR-4690-5p 68-74 -0.257 97.0 -0.257 97.0 noncon
hsa-miR-610 121-127 -0.256 93.0 -0.256 95.0 noncon
hsa-miR-5703 329-335 -0.255 96.0 -0.208 94.0 noncon
hsa-miR-4434 329-335 -0.255 96.0 -0.208 95.0 noncon
hsa-miR-4653-3p 104-110 -0.254 96.0 -0.254 97.0 noncon
hsa-miR-6825-3p 1406-1412 -0.254 91.0 -0.207 89.0 noncon
hsa-miR-6748-3p 554-560 -0.251 92.0 -0.205 91.0 noncon