FuncClass

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Pathway Map
B4GALT3



General Information
Gene Symbol:   
B4GALT3
Protein name:   
Beta-1,4-galactosyltransferase 3
Enzyme Class:   
Glycosyltransferase
CAZy Family:   
GT7
E.C. No:   
2.4.1.90
Organs:   
Reaction (SNFG):   
+
→
+ UDP
Reaction (IUBMB):   
No specified reaction.
About

• Prefers to act on the GlcNAcβ1-4Manα1-3 arm of N-glycans only.

Related Pathway
KEGG ORTHOLOGY:   
K07968
KEGG Pathway:   
ko00510  ko00513  ko00514  ko00515  ko00533  ko00601  ko01100 
Reactome:   
R-HSA-2022854
Related Database
Organism:   
Homo sapiens
Uniprot:   
O60512 
NCBI GeneID:   
8703
GlyMap GeneID:   
8703
DNA aRefSeq:   
NM_001199873.1 
Protein RefSeq:   
NP_001186802.1 
BRENDA:   
Kinetic info.
OMIM number:   
604014
GeneCards database:   
B4GALT3
Enzyme Specificity
Glycan Type:  
     N-linked, O-linked (other), GSL
Compartment:  
     Cis, Medial, Trans, TGN
Substrate:  
     GlcNAc(b1-?)
Product:  
     Gal(b1-4)GlcNAc(b1-?)
Constraints:  
     !Gal(b1-3)GlcNAc(b1-?)&!@GlcNAc(b1-4)...Man(b1-4)
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:    5.75e-04    (pmol/cell • hr)       KM:    1.50e+08    (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 20 10 0 RPKM
Expression Data in Cells {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 80 60 40 20 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
No high degree of confidence data
miRNA-GlycoEnzyme Interactome {ref. 9}
miRNA Name Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
hsa-miR-1247-3p 373-380 -0.676 99.0 -0.676 99.0 noncon
hsa-miR-3175 52-59 -0.519 99.0 -0.519 99.0 noncon
hsa-miR-4530 142-149 -0.486 99.0 -0.486 99.0 noncon
hsa-miR-3177-3p 111-117 -0.434 95.0 -0.434 96.0 noncon
hsa-miR-4640-3p 119-126 -0.431 97.0 -0.431 98.0 noncon
hsa-miR-433-3p 23-30 -0.419 99.0 -0.419 99.0 con
hsa-miR-27b-3p 213-220 -0.41 98.0 -0.41 99.0 con
hsa-miR-27a-3p 213-220 -0.41 98.0 -0.41 99.0 con
hsa-miR-3913-3p 225-232 -0.401 98.0 -0.401 98.0 noncon
hsa-miR-338-3p 424-431 -0.391 99.0 -0.391 99.0 noncon
hsa-miR-6511a-5p 417-424 -0.391 99.0 -0.391 99.0 noncon
hsa-miR-6804-5p 58-65 -0.379 96.0 -0.379 97.0 noncon
hsa-miR-6743-5p 263-270 -0.368 98.0 -0.368 98.0 noncon
hsa-miR-151a-5p 335-341 -0.364 92.0 -0.364 94.0 noncon
hsa-miR-151b 335-341 -0.364 92.0 -0.364 94.0 noncon
hsa-miR-584-3p 95-102 -0.35 97.0 -0.35 98.0 noncon
hsa-miR-2276-5p 81-88 -0.345 98.0 -0.345 99.0 noncon
hsa-miR-4688 263-270 -0.342 97.0 -0.342 97.0 noncon
hsa-miR-6507-3p 492-498 -0.338 98.0 -0.338 99.0 noncon
hsa-miR-615-5p 287-294 -0.33 95.0 -0.33 95.0 noncon
hsa-miR-4689 67-73 -0.326 97.0 -0.326 98.0 noncon
hsa-miR-5591-5p 434-440 -0.31 94.0 -0.31 95.0 noncon
hsa-miR-6726-5p 434-440 -0.307 94.0 -0.307 95.0 noncon
hsa-miR-3184-5p 399-405 -0.307 93.0 -0.307 95.0 noncon
hsa-miR-1910-3p 417-424 -0.302 99.0 -0.302 99.0 noncon
hsa-miR-6766-5p 56-62 -0.299 92.0 -0.299 93.0 noncon
hsa-miR-920 434-440 -0.292 96.0 -0.292 97.0 noncon
hsa-miR-6756-5p 56-62 -0.292 90.0 -0.292 92.0 noncon
hsa-miR-4532 374-380 -0.29 92.0 -0.29 94.0 noncon
hsa-miR-4300 434-440 -0.288 93.0 -0.288 95.0 noncon
hsa-miR-3184-5p 296-302 -0.282 91.0 -0.282 93.0 noncon
hsa-miR-4419a 134-141 -0.281 94.0 -0.281 95.0 noncon
hsa-miR-4633-3p 433-439 -0.273 95.0 -0.273 97.0 noncon
hsa-miR-6129 134-141 -0.273 93.0 -0.273 95.0 noncon
hsa-miR-4510 134-141 -0.273 93.0 -0.273 95.0 noncon
hsa-miR-6133 134-141 -0.273 93.0 -0.273 95.0 noncon
hsa-miR-6130 134-141 -0.273 93.0 -0.273 95.0 noncon
hsa-miR-6130 436-442 -0.271 93.0 -0.271 95.0 noncon
hsa-miR-4419a 436-442 -0.271 93.0 -0.271 95.0 noncon
hsa-miR-423-5p 296-302 -0.271 91.0 -0.271 93.0 noncon
hsa-miR-6127 134-141 -0.265 92.0 -0.265 94.0 noncon
hsa-miR-423-5p 399-405 -0.263 90.0 -0.263 92.0 noncon
hsa-miR-491-5p 54-60 -0.262 92.0 -0.262 94.0 noncon
hsa-miR-412-3p 389-395 -0.26 95.0 -0.26 96.0 noncon
hsa-miR-4510 436-442 -0.26 92.0 -0.26 94.0 noncon
hsa-miR-6133 436-442 -0.26 92.0 -0.26 94.0 noncon
hsa-miR-6754-3p 389-395 -0.259 95.0 -0.259 96.0 noncon
hsa-miR-6500-5p 433-439 -0.251 94.0 -0.251 96.0 noncon