FuncClass

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Pathway Map
COLGALT1



General Information
Gene Symbol:   
COLGALT1
Protein name:   
Procollagen galactosyltransferase 1
Enzyme Class:   
Glycosyltransferase
CAZy Family:   
GT25
E.C. No:   
2.4.1.50
Organs:   
Reaction (SNFG):   

5-hydroxy-L-lysyl- → Gal(b1-?)-5-hydroxy-L-lysyl-
Reaction (IUBMB):   
No specified reaction.
About

• Widely expressed (α1-2)GalT that modifies 5-hydroxy-L-lysyl- on collagen and collagen-like domains
• This is an ER resident enzyme involved in the biosynthesis of collagen type IV
• Glycosylation occurs before the formation of the collagen triple helix
• Compared to COLGALT1, COLGALT2 is only expressed at lower levels in the nervous system
• The product of COLGALT1/2 is modified by glucose, though the enzyme mediating this feature is yet unknown

Related Pathway
KEGG ORTHOLOGY:   
KEGG Pathway:   
No Record 
Reactome:   
R-HSA-1650814
Related Database
Organism:   
Homo sapiens
Uniprot:   
Q8NBJ5 
NCBI GeneID:   
79709
GlyMap GeneID:   
79709
DNA aRefSeq:   
NM_024656.3 
Protein RefSeq:   
NP_078932.2 
BRENDA:   
Kinetic info.
OMIM number:   
617531
GeneCards database:   
COLGALT1
Enzyme Specificity
Glycan Type:  
     
Compartment:  
     
Substrate:  
     5-hydroxy-L-lysyl-
Product:  
     Gal(b1-?)-5-hydroxy-L-lysyl-
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
No expression data available.
Expression Data in Cells
No expression data available.
Transcription factor {ref. 10}
No high degree of confidence data