FuncClass

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Pathway Map
FUT11



General Information
Gene Symbol:   
FUT11
Protein name:   
Alpha-(1,3)-fucosyltransferase 11
Enzyme Class:   
Glycosyltransferase
CAZy Family:   
GT10
E.C. No:   
2.4.1.152
Organs:   
Reaction (SNFG):   
+
→
+ GDP
Reaction (IUBMB):   
No specified reaction.
About

• FUT 10 and 11 are invertebrate and plant core α3-fucosyltransferases that are expressed in the ER (and not Golgi).
• They attach α(1,3)Fuc to the innermost core GlcNAc of the N-glycans on conalbumin glycopeptide substrates and also synthetic biantennary N-glycans.
• It is generally accepted that the core α3-fucosylation mediated by these enzymes does not occur in humans.
• However the wide spread expression of core α(1,3)Fuc in pollen, foods, parasites and insect venom may result in IgE dependent allergic reactions in humans.

Related Pathway
KEGG ORTHOLOGY:   
K11257
KEGG Pathway:   
No Record 
Reactome:   
R-HSA-9037629
Related Database
Organism:   
Homo sapiens
Uniprot:   
Q495W5 
NCBI GeneID:   
170384
GlyMap GeneID:   
170384
DNA aRefSeq:   
NM_001284194.1 
Protein RefSeq:   
NP_001271123.1 
BRENDA:   
Kinetic info.
OMIM number:   
-
GeneCards database:   
FUT11
Enzyme Specificity
Glycan Type:  
     N-linked
Compartment:  
     ER
Substrate:  
     ...GlcNAc(b1-?)Asn
Product:  
     ...[Fuc(a1-3)]GlcNAc(b1-?)Asn
Constraints:  
     nGlcNAc(b1-2)Man(a1-3)[Man(a1-6)]Man(b1-4)GlcNAc(b1-4)GlcNAc(b1-?)Asn>=1&!GlcNAc(b1-4)^Man(b1-4)&!Fuc(a1-6)...GlcNAc(b1-?)Asn
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:    3.80e-05    (pmol/cell • hr)       KM:    2.50e+07    (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 10 8 6 4 2 0 RPKM
Expression Data in Cells {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 50 40 30 20 10 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
No high degree of confidence data
miRNA-GlycoEnzyme Interactome {ref. 9}
miRNA Name Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
hsa-miR-7156-3p 40-47 -0.415 98.0 -0.415 98.0 noncon
hsa-miR-24-2-5p 4083-4090 -0.412 95.0 -0.328 95.0 noncon
hsa-miR-24-1-5p 4083-4090 -0.404 95.0 -0.322 95.0 noncon
hsa-miR-4667-5p 546-553 -0.393 98.0 -0.393 98.0 noncon
hsa-miR-3927-3p 3108-3115 -0.385 98.0 -0.34 98.0 noncon
hsa-miR-8089 546-553 -0.38 98.0 -0.38 98.0 noncon
hsa-miR-3684 336-343 -0.38 96.0 -0.38 97.0 noncon
hsa-miR-4700-5p 546-553 -0.375 98.0 -0.375 98.0 noncon
hsa-miR-296-5p 4554-4561 -0.374 94.0 -0.299 93.0 noncon
hsa-miR-34c-5p 83-90 -0.352 94.0 -0.352 96.0 con
hsa-miR-6499-5p 2183-2189 -0.35 90.0 -0.309 89.0 noncon
hsa-miR-34a-5p 83-90 -0.35 94.0 -0.35 96.0 con
hsa-miR-6831-5p 3108-3115 -0.34 97.0 -0.301 97.0 noncon
hsa-miR-6834-3p 226-233 -0.336 96.0 -0.336 97.0 noncon
hsa-miR-449b-5p 83-90 -0.336 93.0 -0.336 95.0 con
hsa-miR-4325 1822-1829 -0.327 98.0 -0.289 98.0 noncon
hsa-miR-367-3p 4216-4223 -0.325 96.0 -0.261 96.0 con
hsa-miR-449a 83-90 -0.318 92.0 -0.318 94.0 con
hsa-miR-5189-3p 4581-4588 -0.316 95.0 -0.253 95.0 noncon
hsa-miR-192-3p 52-59 -0.314 97.0 -0.314 98.0 noncon
hsa-miR-6747-3p 3647-3654 -0.313 97.0 -0.251 96.0 noncon
hsa-miR-363-3p 4216-4223 -0.309 96.0 -0.248 96.0 con
hsa-miR-3173-5p 1020-1027 -0.309 96.0 -0.274 96.0 noncon
hsa-miR-4784 554-560 -0.301 97.0 -0.301 97.0 noncon
hsa-miR-32-5p 4216-4223 -0.299 96.0 -0.24 95.0 con
hsa-miR-6084 195-201 -0.298 92.0 -0.298 94.0 noncon
hsa-miR-25-3p 4216-4223 -0.296 96.0 -0.238 95.0 con
hsa-miR-7156-3p 1101-1108 -0.291 95.0 -0.258 95.0 noncon
hsa-miR-6799-3p 1020-1027 -0.285 95.0 -0.253 95.0 noncon
hsa-miR-4650-3p 217-224 -0.283 92.0 -0.283 94.0 noncon
hsa-miR-365b-5p 1903-1910 -0.283 96.0 -0.251 96.0 noncon
hsa-miR-365a-5p 1903-1910 -0.283 96.0 -0.251 96.0 noncon
hsa-miR-6809-5p 1541-1548 -0.278 93.0 -0.247 94.0 noncon
hsa-miR-653-3p 498-505 -0.276 97.0 -0.276 98.0 noncon
hsa-miR-92a-3p 4216-4223 -0.275 95.0 -0.221 95.0 con
hsa-miR-4743-3p 1702-1709 -0.27 98.0 -0.239 98.0 noncon
hsa-miR-4423-5p 156-163 -0.269 92.0 -0.269 95.0 noncon
hsa-miR-4325 1766-1773 -0.268 96.0 -0.238 97.0 noncon
hsa-miR-92b-3p 4216-4223 -0.267 95.0 -0.215 95.0 con
hsa-miR-3156-3p 392-399 -0.264 95.0 -0.264 96.0 noncon
hsa-miR-4286 2169-2176 -0.264 96.0 -0.234 96.0 noncon
hsa-miR-4689 554-560 -0.264 96.0 -0.264 97.0 noncon
hsa-miR-6821-3p 4099-4106 -0.263 96.0 -0.212 95.0 noncon
hsa-miR-4759 3244-3250 -0.262 96.0 -0.232 96.0 noncon
hsa-miR-4776-5p 435-442 -0.257 93.0 -0.257 95.0 noncon
hsa-miR-1915-5p 55-61 -0.255 90.0 -0.255 93.0 noncon
hsa-miR-4446-3p 860-867 -0.254 93.0 -0.225 93.0 noncon
hsa-miR-6873-5p 1872-1879 -0.254 94.0 -0.225 94.0 noncon
hsa-miR-3150b-3p 554-560 -0.253 95.0 -0.253 96.0 noncon
hsa-miR-7703 4161-4167 -0.253 96.0 -0.204 96.0 noncon
hsa-miR-6747-3p 1068-1075 -0.252 95.0 -0.224 95.0 noncon
hsa-miR-6828-3p 111-117 -0.25 95.0 -0.25 96.0 noncon