FuncClass

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Pathway Map
FUT2



General Information
Gene Symbol:   
FUT2
Protein name:   
Galactoside 2-alpha-L-fucosyltransferase 2
Enzyme Class:   
Glycosyltransferase
CAZy Family:   
GT11
E.C. No:   
2.4.1.344
Organs:   
Reaction (SNFG):   
+
→
+ GDP
+
→
+ GDP
+
→
+ GDP
Reaction (IUBMB):   
No specified reaction.
About

• FUT2 (Se) is expressed predominantly in epithelial cells and exocrine secretions (cells from endoderm).
• Also see notes on FUT1.

Related Pathway
KEGG ORTHOLOGY:   
K00718
KEGG Pathway:   
ko00601  ko00603  ko01100 
Reactome:   
R-HSA-9033807
Related Database
Organism:   
Homo sapiens
Uniprot:   
Q10981 
NCBI GeneID:   
2524
GlyMap GeneID:   
2524
DNA aRefSeq:   
NM_000511.5 
Protein RefSeq:   
NP_000502.4 
BRENDA:   
Kinetic info.
OMIM number:   
-
GeneCards database:   
FUT2
Enzyme Specificity
Glycan Type:  
     N-linked, O-linked (mucin type), GSL
Compartment:  
     Cis, Medial, Trans, TGN
Substrate:  
     Gal(b1-?)...Gal(b1-?) or Gal(b1-?)GalNAc(b1-?) or Gal(b1-?)GlcNAc(b1-?)
Product:  
     Fuc(a1-2)Gal(b1-?)...Gal(b1-?) or Fuc(a1-2)Gal(b1-?)GalNAc(b1-?) or Fuc(a1-2)Gal(b1-?)GlcNAc(b1-?)
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:    3.75e-06    (pmol/cell • hr)       KM:    1.40e+09    (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 30 20 10 0 RPKM
Expression Data in Cells {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 40 30 20 10 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
No high degree of confidence data
miRNA-GlycoEnzyme Interactome {ref. 9}
miRNA Name Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
hsa-miR-6887-5p 760-767 -0.533 97.0 -0.533 97.0 noncon
hsa-miR-6795-5p 760-767 -0.509 96.0 -0.509 97.0 noncon
hsa-miR-4435 241-248 -0.502 99.0 -0.502 99.0 noncon
hsa-miR-6836-3p 811-818 -0.457 99.0 -0.457 99.0 noncon
hsa-miR-3975 845-852 -0.438 99.0 -0.438 99.0 noncon
hsa-miR-7109-5p 761-768 -0.437 97.0 -0.437 98.0 noncon
hsa-miR-8064 1757-1764 -0.36 98.0 -0.36 98.0 noncon
hsa-miR-3652 650-657 -0.348 98.0 -0.348 98.0 noncon
hsa-miR-4430 650-657 -0.337 98.0 -0.337 98.0 noncon
hsa-miR-6829-3p 810-817 -0.335 98.0 -0.335 98.0 noncon
hsa-miR-6791-3p 810-817 -0.335 98.0 -0.335 98.0 noncon
hsa-miR-183-5p.1 1485-1492 -0.332 97.0 -0.332 97.0 noncon
hsa-miR-1273f 427-434 -0.33 98.0 -0.33 98.0 noncon
hsa-miR-3938 1837-1844 -0.328 97.0 -0.328 98.0 noncon
hsa-miR-6071 685-692 -0.32 97.0 -0.32 98.0 noncon
hsa-miR-3663-5p 507-514 -0.3 98.0 -0.3 98.0 noncon
hsa-miR-221-5p 1826-1833 -0.299 97.0 -0.299 98.0 noncon
hsa-miR-4294 422-429 -0.298 95.0 -0.298 96.0 noncon
hsa-miR-4649-3p 847-854 -0.296 98.0 -0.296 98.0 noncon
hsa-miR-6876-5p 737-744 -0.293 98.0 -0.293 98.0 noncon
hsa-miR-4476 737-744 -0.293 98.0 -0.293 98.0 noncon
hsa-miR-8073 1826-1833 -0.291 97.0 -0.291 98.0 noncon
hsa-miR-7156-3p 120-127 -0.286 95.0 -0.286 96.0 noncon
hsa-miR-363-5p 1083-1090 -0.286 95.0 -0.286 96.0 noncon
hsa-miR-4447 1676-1683 -0.285 96.0 -0.285 97.0 noncon
hsa-miR-4472 1676-1683 -0.285 96.0 -0.285 97.0 noncon
hsa-miR-5187-5p 618-625 -0.283 94.0 -0.283 95.0 noncon
hsa-miR-8086 234-240 -0.273 90.0 -0.273 94.0 noncon
hsa-miR-5702 1909-1915 -0.272 94.0 -0.272 96.0 noncon
hsa-miR-664a-3p 1929-1936 -0.27 98.0 -0.27 99.0 noncon
hsa-miR-3152-5p 812-819 -0.268 94.0 -0.268 96.0 noncon
hsa-miR-431-5p 419-425 -0.267 94.0 -0.267 96.0 noncon
hsa-miR-6771-3p 1028-1035 -0.265 97.0 -0.265 98.0 noncon
hsa-miR-4309 423-429 -0.264 95.0 -0.264 96.0 noncon
hsa-miR-488-3p 674-681 -0.264 97.0 -0.264 98.0 noncon
hsa-miR-4725-5p 528-535 -0.261 91.0 -0.261 94.0 noncon
hsa-miR-6842-3p 651-657 -0.256 93.0 -0.256 95.0 noncon
hsa-miR-1224-3p 1807-1814 -0.251 95.0 -0.251 97.0 noncon