FuncClass

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Pathway Map
FUT9



General Information
Gene Symbol:   
FUT9
Protein name:   
Alpha-(1,3)-fucosyltransferase 9
Enzyme Class:   
Glycosyltransferase
CAZy Family:   
GT10
E.C. No:   
2.4.1.152
Organs:   
Reaction (SNFG):   
+
→
+ GDP
+
→
+ GDP
Reaction (IUBMB):   
No specified reaction.
About

• FUT9 is restricted to subpopulations such as granulocytes, natural killer cells, and B cells. It is also highly expressed in the brain.
• In blood cells, it forms the LewisX/CD15/SSEA-1 antigen and it also helps form LeY structures.
• May participate in forming E-selectin ligand in humans, along with FUT4 and 7.

Related Pathway
KEGG ORTHOLOGY:   
K03663
KEGG Pathway:   
ko00515  ko00601  ko00603  ko01100 
Reactome:   
R-HSA-9037629
Related Database
Organism:   
Homo sapiens
Uniprot:   
Q9Y231 
NCBI GeneID:   
10690
GlyMap GeneID:   
10690
DNA aRefSeq:   
NM_006581.3 
Protein RefSeq:   
NP_006572.2 
BRENDA:   
Kinetic info.
OMIM number:   
606865
GeneCards database:   
FUT9
Enzyme Specificity
Glycan Type:  
     N-linked, O-linked (mucin type), O-linked (other), GSL
Compartment:  
     Cis, Medial, Trans, TGN
Substrate:  
     Gal(b1-4)GlcNAc(b1-?) or ...GlcNAc(b1-3)Gal(b1-4)GlcNAc(b1-?)
Product:  
     Gal(b1-4)[Fuc(a1-3)]GlcNAc(b1-?) or ...GlcNAc(b1-3)Gal(b1-4)[Fuc(a1-3)]GlcNAc(b1-?)
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:    3.75e-06    (pmol/cell • hr)       KM:    1.40e+09    (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 10 8 6 4 2 0 RPKM
Expression Data in Cells {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 8 6 4 2 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
No high degree of confidence data
miRNA-GlycoEnzyme Interactome {ref. 9}
miRNA Name Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
hsa-miR-22-3p 10905-10912 -0.438 98.0 -0.438 99.0 con
hsa-miR-328-3p 7768-7775 -0.352 97.0 -0.352 98.0 noncon
hsa-miR-6851-3p 7767-7774 -0.345 97.0 -0.345 98.0 noncon
hsa-miR-3145-3p 7947-7953 -0.343 98.0 -0.343 99.0 noncon
hsa-miR-16-2-3p 3404-3410 -0.337 99.0 -0.337 99.0 noncon
hsa-miR-195-3p 3404-3410 -0.325 99.0 -0.325 99.0 noncon
hsa-miR-22-3p 10036-10042 -0.325 96.0 -0.325 97.0 con
hsa-miR-3145-3p 9993-10000 -0.319 98.0 -0.319 98.0 noncon
hsa-miR-4286 1061-1068 -0.319 97.0 -0.319 98.0 noncon
hsa-miR-218-5p 9433-9439 -0.308 95.0 -0.308 97.0 con
hsa-miR-1263 4327-4334 -0.307 93.0 -0.307 95.0 noncon
hsa-miR-648 9435-9442 -0.301 97.0 -0.301 98.0 noncon
hsa-miR-449b-5p 9709-9716 -0.297 90.0 -0.297 93.0 con
hsa-miR-5001-3p 11172-11179 -0.296 96.0 -0.296 97.0 noncon
hsa-miR-5739 2009-2015 -0.294 90.0 -0.294 93.0 noncon
hsa-miR-648 16-22 -0.288 96.0 -0.288 97.0 noncon
hsa-miR-381-5p 11260-11266 -0.287 90.0 -0.287 92.0 noncon
hsa-miR-3134 7204-7211 -0.284 96.0 -0.284 97.0 noncon
hsa-miR-301b-3p 9247-9254 -0.284 95.0 -0.284 97.0 con
hsa-miR-301a-3p 9247-9254 -0.284 95.0 -0.284 97.0 con
hsa-miR-890 48-55 -0.283 97.0 -0.283 98.0 noncon
hsa-miR-6882-3p 10904-10910 -0.281 94.0 -0.281 96.0 noncon
hsa-miR-3666 9247-9254 -0.276 95.0 -0.276 97.0 con
hsa-miR-130a-3p 9247-9254 -0.276 95.0 -0.276 96.0 con
hsa-miR-4295 9247-9254 -0.276 95.0 -0.276 97.0 con
hsa-miR-16-2-3p 4762-4768 -0.269 98.0 -0.269 98.0 noncon
hsa-miR-1825 11274-11281 -0.268 95.0 -0.268 97.0 noncon
hsa-miR-130b-3p 9247-9254 -0.268 95.0 -0.268 96.0 con
hsa-miR-4452 11360-11367 -0.266 98.0 -0.266 99.0 noncon
hsa-miR-331-5p 202-209 -0.265 93.0 -0.265 95.0 noncon
hsa-miR-483-3p.1 8634-8641 -0.259 95.0 -0.259 97.0 noncon
hsa-miR-642b-3p 89-95 -0.258 96.0 -0.258 97.0 noncon
hsa-miR-642a-3p 89-95 -0.258 96.0 -0.258 97.0 noncon
hsa-miR-195-3p 4762-4768 -0.257 98.0 -0.257 98.0 noncon
hsa-miR-19a-3p 9246-9252 -0.254 90.0 -0.254 93.0 con
hsa-miR-19b-3p 9246-9252 -0.254 90.0 -0.254 93.0 con
hsa-miR-6830-5p 11286-11293 -0.253 96.0 -0.253 97.0 noncon
hsa-miR-5002-3p 10159-10165 -0.252 90.0 -0.252 93.0 noncon
hsa-miR-484 11199-11205 -0.25 97.0 -0.25 97.0 noncon