FuncClass

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Pathway Map
GALNT2



General Information
Gene Symbol:   
GALNT2
Protein name:   
Polypeptide N-acetylgalactosaminyltransferase 2
Enzyme Class:   
Glycosyltransferase
CAZy Family:   
CBM13
E.C. No:   
2.4.1.41
Organs:   
Reaction (SNFG):   
+ Ser →
+ UDP
+ Thr →
+ UDP
Reaction (IUBMB):   
No specified reaction.
About

• ppGalNAc-T1 is localized throughout the Golgi
• Mutations in ppGalNAcT activity can result in various diseases.
• ppGalNAc-T2 and ppGalNAc-T3 were more abundant in the trans and medial Golgi.
• GALNT2 has broad specificity for a number of mucin proteins like MUC1, MUC5AC etc. It may also be involved in glycosylating IgA1 hinge region.

Related Pathway
KEGG ORTHOLOGY:   
K00710
KEGG Pathway:   
ko00512  ko01100 
Reactome:   
R-HSA-6811436
Related Database
Organism:   
Homo sapiens
Uniprot:   
Q10471 
NCBI GeneID:   
2590
GlyMap GeneID:   
2590
DNA aRefSeq:   
NM_001291866.1 
Protein RefSeq:   
NP_001278795.1 
BRENDA:   
Kinetic info.
OMIM number:   
602274
GeneCards database:   
GALNT2
Enzyme Specificity
Glycan Type:  
     O-linked (mucin type)
Compartment:  
     Cis, Medial, Trans
Substrate:  
     Ser or Thr
Product:  
     GalNAc(a1-?)Ser or GalNAc(a1-?)Thr
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 30 20 10 0 RPKM
Expression Data in Cells {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 300 200 100 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
No high degree of confidence data
miRNA-GlycoEnzyme Interactome {ref. 9}
miRNA Name Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
hsa-miR-4767 2129-2136 -0.577 99.0 -0.54 99.0 noncon
hsa-miR-4433a-5p 587-594 -0.489 99.0 -0.489 99.0 noncon
hsa-miR-7108-3p 360-367 -0.481 97.0 -0.481 98.0 noncon
hsa-miR-7108-3p 1361-1368 -0.439 96.0 -0.412 96.0 noncon
hsa-miR-4767 1243-1250 -0.418 97.0 -0.393 96.0 noncon
hsa-miR-6786-3p 2252-2259 -0.405 91.0 -0.38 92.0 noncon
hsa-miR-6786-3p 852-859 -0.385 90.0 -0.363 91.0 noncon
hsa-miR-202-3p 101-108 -0.382 97.0 -0.382 98.0 noncon
hsa-miR-6796-5p 674-681 -0.348 96.0 -0.328 96.0 noncon
hsa-miR-4750-3p 1317-1324 -0.344 97.0 -0.324 98.0 noncon
hsa-miR-491-5p 673-680 -0.344 97.0 -0.324 97.0 noncon
hsa-miR-5004-5p 2474-2481 -0.342 96.0 -0.322 97.0 noncon
hsa-miR-6803-3p 4395-4402 -0.336 91.0 -0.002 18.0 noncon
hsa-miR-6883-5p 2374-2381 -0.331 97.0 -0.311 97.0 noncon
hsa-miR-6785-5p 2374-2381 -0.329 97.0 -0.31 97.0 noncon
hsa-miR-149-3p 2374-2381 -0.323 97.0 -0.304 97.0 noncon
hsa-miR-6875-5p 492-498 -0.316 97.0 -0.316 97.0 noncon
hsa-miR-4500 102-108 -0.316 91.0 -0.316 93.0 con
hsa-miR-6802-3p 3988-3995 -0.315 94.0 -0.002 35.0 noncon
hsa-miR-5196-3p 568-575 -0.315 97.0 -0.315 98.0 noncon
hsa-miR-4728-5p 2374-2381 -0.313 96.0 -0.295 96.0 noncon
hsa-miR-4688 2110-2116 -0.31 95.0 -0.292 96.0 noncon
hsa-miR-96-5p 2319-2326 -0.309 95.0 -0.291 96.0 con
hsa-miR-2355-5p 4536-4543 -0.309 97.0 -0.002 30.0 noncon
hsa-miR-1271-5p 2319-2326 -0.306 95.0 -0.288 96.0 con
hsa-miR-6888-5p 4787-4794 -0.305 98.0 0.0 31.0 noncon
hsa-miR-6890-5p 1000-1007 -0.296 96.0 -0.279 97.0 noncon
hsa-miR-3667-5p 954-960 -0.295 97.0 -0.278 97.0 noncon
hsa-miR-4313 370-377 -0.287 92.0 -0.287 94.0 noncon
hsa-miR-561-5p 2619-2626 -0.286 96.0 -0.269 96.0 noncon
hsa-miR-6134 545-552 -0.285 93.0 -0.285 95.0 noncon
hsa-miR-3126-5p 492-498 -0.283 95.0 -0.283 97.0 noncon
hsa-miR-4726-5p 4020-4027 -0.283 91.0 -0.002 17.0 noncon
hsa-miR-6838-3p 2361-2368 -0.282 96.0 -0.266 97.0 noncon
hsa-miR-942-5p 2646-2653 -0.281 97.0 -0.263 97.0 noncon
hsa-miR-4667-3p 2053-2060 -0.273 95.0 -0.257 96.0 noncon
hsa-miR-3657 589-595 -0.271 91.0 -0.271 94.0 noncon
hsa-miR-6810-3p 2263-2269 -0.27 92.0 -0.254 94.0 noncon
hsa-miR-5088-5p 2415-2421 -0.267 94.0 -0.252 95.0 noncon
hsa-miR-6743-5p 2110-2116 -0.256 92.0 -0.241 93.0 noncon
hsa-miR-7162-3p 103-109 -0.254 97.0 -0.254 98.0 noncon
hsa-miR-3120-3p 4801-4808 -0.254 97.0 0.0 26.0 noncon